Microglia Function in the Normal Brain

Simple item page
dc.catalogadorjwg
dc.contributor.authorHeredia, María Florencia
dc.contributor.authorMuñoz Reyes, Paola Cecilia
dc.contributor.authorSalgado Cortés, Nicole Andrea
dc.contributor.authorVon Bernhardi Montgomery, Rommy Edth B.
dc.date.accessioned2024-01-30T19:41:49Z
dc.date.available2024-01-30T19:41:49Z
dc.date.issued2016
dc.description.abstractThe activation of microglia has been recognized for over a century by their morphological changes. Long slender microglia acquire a short sturdy ramified shape when activated. During the past 20 years, microglia have been accepted as an essential cellular component for understanding the pathogenic mechanism of many brain diseases, including neurodegenerative diseases. More recently, functional studies and imaging in mouse models indicate that microglia are active in the healthy central nervous system. It has become evident that microglia release several signal molecules that play key roles in the crosstalk among brain cells, i.e., astrocytes and oligodendrocytes with neurons, as well as with regulatory immune cells. Recent studies also reveal the heterogeneous nature of microglia diverse functions depending on development, previous exposure to stimulation events, brain region of residence, or pathological state. Subjects to approach by future research are still the unresolved questions regarding the conditions and mechanisms that render microglia protective, capable of preventing or reducing damage, or deleterious, capable of inducing or facilitating the progression of neuropathological diseases. This novel knowledge will certainly change our view on microglia as therapeutic target, shifting our goal from their general silencing to the generation of treatments able to change their activation pattern.
dc.description.funderOtro
dc.fuente.origenHistorial Académico
dc.identifier.citationvon Bernhardi R , Heredia F, Salgado N , Munoz P. Microglia Function in the Normal Brain. Glial Cells In Health And Disease Of The Cns. 2016;949:67-92.
dc.identifier.issn0065-2598
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007%2F978-3-319-40764-7.pdf
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81079
dc.identifier.wosidWOS:000400932800004
dc.information.autorucEscuela de Medicina; Heredia, María Florencia;S/I;1017991
dc.information.autorucFacultad de Ciencias Biológicas; Salgado Cortes Nicole Andrea; 0000-0003-1658-9641; 195452
dc.information.autorucEscuela de Medicina; Munoz Reyes Paola Cecilia; 1003918
dc.information.autorucEscuela de Medicina; Von Bernhardi Montgomery Rommy Edth B.; ; 62523
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final92
dc.pagina.inicio67
dc.revistaGlial Cells in Health and Disease of the CNS
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMicroglia Function in the Normal Brain
dc.typecapítulo de libro
dc.volumen949
sipa.codpersvinculados1017991
sipa.codpersvinculados195452
sipa.codpersvinculados1003918
sipa.codpersvinculados62523
sipa.trazabilidadORCID;2024-01-15
Files
Collections
Capítulos de libros