Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) rnRNA and integrin alpha 5 expression in the rat pineal gland

Simple item page
dc.contributor.authorDagnino Subiabre, Alexies
dc.contributor.authorZepeda Carreno, Rodrigo
dc.contributor.authorDiaz Veliz, Gabriela
dc.contributor.authorMora, Sergio
dc.contributor.authorAboitiz, Francisco
dc.date.accessioned2024-01-10T13:11:44Z
dc.date.available2024-01-10T13:11:44Z
dc.date.issued2006
dc.description.abstractChronic stress affects brain areas involved in learning and emotional responses. These alterations have been related with the development of cognitive deficits in major depression. Moreover, stress induces deleterious actions on the epithalamic pineal organ, a gland involved in a wide range of physiological functions. The aim of this study was to investigate whether the stress effects on the pineal gland are related with changes in the expression of neurotrophic factors and cell adhesion molecules. Using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot, we analyzed the effect of chronic immobilization stress on the BDNF mRNA and integrin alpha 5 expression in the rat pineal gland. We found that BDNF is produced in situ in the pineal gland. Chronic immobilization stress induced upregulation of BDNF mRNA and integrin alpha 5 expression in the rat pineal gland but did not produce changes in beta-actin mRNA or in GAPDH expression. Stressed animals also evidenced an increase in anxiety-like behavior and acute gastric lesions. These results suggest that BDNF and integrin a5 may have a counteracting effect to the deleterious actions of immobilization stress on functionally stimulated pinealocytes. Furthermore, this study proposes that the pineal gland may be a target of glucocorticoid damage during stress. (c) 2006 Elsevier B.V. All rights reserved.
dc.fechaingreso.objetodigital21-03-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.brainres.2006.02.118
dc.identifier.eissn1872-6240
dc.identifier.issn0006-8993
dc.identifier.pubmedidMEDLINE:16626638
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2006.02.118
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78089
dc.identifier.wosidWOS:000238001500004
dc.information.autorucMedicina;Aboitiz F;S/I;100165
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final34
dc.pagina.inicio27
dc.publisherELSEVIER SCIENCE BV
dc.revistaBRAIN RESEARCH
dc.rightsacceso restringido
dc.subjectstress
dc.subjectBDNF
dc.subjectintegrin alpha 5
dc.subjectpineal gland
dc.subjectdepression
dc.subjectMEDIAL PREFRONTAL CORTEX
dc.subjectSHREW TUPAIA-BELANGERI
dc.subjectGLUCOCORTICOID SECRETION
dc.subjectDENDRITIC REORGANIZATION
dc.subjectDEPRESSED-PATIENTS
dc.subjectREACTIVE RESPONSE
dc.subjectPYRAMIDAL NEURONS
dc.subjectMAJOR DEPRESSION
dc.subjectSUBSTANTIA-NIGRA
dc.subjectGENE-EXPRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) rnRNA and integrin alpha 5 expression in the rat pineal gland
dc.typeartículo
dc.volumen1086
sipa.codpersvinculados100165
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-03-21. Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) mRNA and integrin α5 expression in the rat pineal gland.pdf
Size:
3.04 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas