The Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension

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dc.catalogadorvzp
dc.contributor.authorJenifer M. Brown
dc.contributor.authorCassianne Robinson-Cohen
dc.contributor.authorMiguel Angel Luque-Fernandez
dc.contributor.authorMatthew A. Allison
dc.contributor.authorRene Baudrand
dc.contributor.authorJoachim H. Ix
dc.contributor.authorBryan Kestenbaum
dc.contributor.authorIan H. de Boer
dc.contributor.authorAnand Vaidya
dc.date.accessioned2024-05-31T13:40:23Z
dc.date.available2024-05-31T13:40:23Z
dc.date.issued2017
dc.description.abstractBackground: Primary aldosteronism is recognized as a severe form of renin-independent aldosteronism that results in excessive mineralocorticoid receptor (MR) activation. Objective: To investigate whether a spectrum of subclinical renin-independent aldosteronism that increases risk for hypertension exists among normotensive persons. Design: Cohort study. Setting: National community-based study. Participants: 850 untreated normotensive participants in MESA (Multi-Ethnic Study of Atherosclerosis) with measurements of serum aldosterone and plasma renin activity (PRA). Measurements: Longitudinal analyses investigated whether aldosterone concentrations, in the context of physiologic PRA phenotypes (suppressed, ≤0.50 μg/L per hour; indeterminate, 0.51 to 0.99 μg/L per hour; unsuppressed, ≥1.0 μg/L per hour), were associated with incident hypertension (defined as systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or initiation of antihypertensive medications). Cross-sectional analyses investigated associations between aldosterone and MR activity, assessed via serum potassium and urinary fractional excretion of potassium.
dc.format.extent16 páginas
dc.fuente.origenORCID
dc.identifier.doi10.7326/m17-0882
dc.identifier.urihttps://doi.org/10.7326/m17-0882
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86152
dc.information.autorucEscuela de Medicina; Baudrand Biggs, Rene Felipe; 0000-0002-8655-4957; 1024
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final641
dc.pagina.inicio660
dc.revistaAnnals of Internal Medicine
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleThe Spectrum of Subclinical Primary Aldosteronism and Incident Hypertension
dc.typeartículo
dc.volumen167
sipa.codpersvinculados1024
sipa.trazabilidadORCID;2024-05-27
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