Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi

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dc.contributor.authorUribe, Pablo
dc.contributor.authorAndrade, Leonardo
dc.contributor.authorGonzalez, Sergio
dc.date.accessioned2024-01-10T13:14:14Z
dc.date.available2024-01-10T13:14:14Z
dc.date.issued2006
dc.description.abstractThe mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase signaling pathway can be activated through mutations of V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) oncogene, frequently found in melanoma (60%), common nevi (CN) (73-82%), and atypical nevi (AN) (52-80%). MAPK activation has been reported between 0 and 22% in nevi, and 86% of primary melanoma, without any knowledge of BRAF mutational status. We studied the correlation of MAPK activation status, BRAF mutation, and B-Raf expression in CN, AN, and melanoma. Using immunohistochemistry, phosphorylated (active) MAPK and B-Raf expression was studied in 24 CN, 21 AN, and 26 primary cutaneous melanomas (PM). BRAF mutations at codon 600 were assessed by PCR-RFLP. Active MAPK was detected in 29% of CN, 48% of AN, and 85% of PM. BRAF mutation was found in 67% of CN, 62% of AN, and 58% of PM. In all, 23% of CN, 54% of AN, and 93% of PM with BRAF mutation have activated MAPK. All lesions expressed B-Raf. BRAF mutation does not seem to be sufficient to produce MAPK activation in melanocytic nevi, and it is suggested that other events are needed to induce MAPK activation, that is, B-Raf overexpression, inhibition of MAPK phosphatases, or suppression of RAF kinase inhibitors.
dc.fechaingreso.objetodigital2024-05-10
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/sj.jid.5700011
dc.identifier.issn0022-202X
dc.identifier.pubmedidMEDLINE:16417232
dc.identifier.urihttps://doi.org/10.1038/sj.jid.5700011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78386
dc.identifier.wosidWOS:000238943900027
dc.information.autorucMedicina;González S;S/I;99856
dc.information.autorucMedicina;Uribe P;S/I;9032
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final166
dc.pagina.inicio161
dc.publisherNATURE PUBLISHING GROUP
dc.revistaJOURNAL OF INVESTIGATIVE DERMATOLOGY
dc.rightsregistro bibliográfico
dc.subjectPROTEIN-KINASE ACTIVATION
dc.subjectSIGNAL-REGULATED KINASES
dc.subjectB-RAF
dc.subjectCUTANEOUS MELANOMAS
dc.subjectTUMOR PROGRESSION
dc.subjectEXPRESSION
dc.subjectCANCER
dc.subjectINHIBITOR
dc.subjectNEOPLASMS
dc.subjectFREQUENCY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi
dc.typeartículo
dc.volumen126
sipa.codpersvinculados99856
sipa.codpersvinculados9032
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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