Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women

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dc.catalogadordfo
dc.contributor.authorde Almeida, Liz Maria
dc.contributor.authorCortés Arancibia, Sandra
dc.contributor.authorVilensky, Marta
dc.contributor.authorValenzuela, Olivia
dc.contributor.authorCortes-Sanabria, Laura
dc.contributor.authorde Souza, Mirian
dc.contributor.authorAlonso Barbeito, Rafael
dc.contributor.authorAbdelhay, Eliana
dc.contributor.authorArtagaveytia, Nora
dc.contributor.authorDaneri-Navarro, Adrian
dc.contributor.authorLlera, Andrea S.
dc.contributor.authorMuller, Bettina
dc.contributor.authorPodhajcer, Osvaldo L.
dc.contributor.authorVelazquez, Carlos
dc.contributor.authorAlcoba, Elsa
dc.contributor.authorAlonso, Isabel
dc.contributor.authorBravo, Alicia, I
dc.contributor.authorCamejo, Natalia
dc.contributor.authorMaria Carraro, Dirce
dc.contributor.authorCastro, Monica
dc.contributor.authorCataldi, Sandra
dc.contributor.authorCayota, Alfonso
dc.contributor.authorCerda, Mauricio
dc.contributor.authorColombo, Alicia
dc.contributor.authorCrocamo, Susanne
dc.contributor.authorDel Toro-Arreola, Alicia
dc.contributor.authorDelgadillo-Cristerna, Raul
dc.contributor.authorDelgado, Lucia
dc.contributor.authorBreitenbach, Marisa Dreyer
dc.contributor.authorFernandez, Elmer
dc.contributor.authorFernandez, Jorge
dc.contributor.authorFernandez, Wanda
dc.contributor.authorFranco-Topete, Ramon A.
dc.contributor.authorGaete, Fancy
dc.contributor.authorGomez, Jorge
dc.contributor.authorGonzalez-Ramirez, Leivy P.
dc.contributor.authorGuerrero, Marisol
dc.contributor.authorGutierrez-Rubio, Susan A.
dc.contributor.authorJalfin, Beatriz
dc.contributor.authorLopez-Vazquez, Alejandra
dc.contributor.authorLoria, Dora
dc.contributor.authorMiguez, Silvia
dc.contributor.authorMoran-Mendoza, Andres de J.
dc.contributor.authorMorgan-Villela, Gilberto
dc.contributor.authorMussetti, Carina
dc.contributor.authorNagai, Maria Aparecida
dc.contributor.authorOceguera-Villanueva, Antonio
dc.contributor.authorReis, Rui M.
dc.contributor.authorRetamales, Javier
dc.contributor.authorRodriguez, Robinson
dc.contributor.authorRosales, Cristina
dc.contributor.authorSalas-Gonzalez, Efrain
dc.contributor.authorSegovia, Laura
dc.contributor.authorSendoya, Juan M.
dc.contributor.authorSilva-Garcia, Aida A.
dc.contributor.authorVina, Stella
dc.contributor.authorZagame, Livia
dc.contributor.authorJones, Beth
dc.contributor.authorSzklo, Moyses
dc.date.accessioned2024-01-22T16:22:20Z
dc.date.available2024-01-22T16:22:20Z
dc.date.issued2022
dc.description.abstractMolecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status not less than or equal to 1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher's exact tests and the OS by Kaplan-Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (>= 60 years) (1.84) compared with younger (<= 40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3389/fonc.2022.845527
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80884
dc.information.autorucEscuela de Medicina; Cortés Arancibia, Sandra; 0000-0003-3293-1419; 1005970
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaForntiers in oncology
dc.rightsacceso restringido
dc.subjectLatin America; breast cancer
dc.subjectGlobal excellence
dc.subjectMolecular subtypes
dc.subjectOncology
dc.subjectPrognosis
dc.subjectRisk factors
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleSocioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1005970
sipa.trazabilidadWOS;2022-07-08
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