Swimming exercise attenuates diabetic myopathy and is associated with histological and mitochondrial changes in pregnant rats (Rattus norvegicus)

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dc.article.number168126
dc.catalogadorjlo
dc.contributor.authorCatinelli, Bruna Bologna
dc.contributor.authorPascon Barbosa, Angélica Mércia
dc.contributor.authorMedolago Carr, Aline
dc.contributor.authorRafael Guilen de Oliveira
dc.contributor.authorBergamo Alves, Fernanda Cristina
dc.contributor.authorMosele, Franciele
dc.contributor.authorChies, Agnaldo Bruno
dc.contributor.authorFelisbino, Sérgio Luis
dc.contributor.authorSobrevia Luarte, Luis Alberto
dc.contributor.authorSouza Rossignoli, Patrícia de
dc.contributor.authorVieira Cunha Rudge, Marilza
dc.date.accessioned2025-12-04T18:03:08Z
dc.date.available2025-12-04T18:03:08Z
dc.date.issued2026
dc.description.abstractAim: Diabetic-induced myopathy (DiM) is reversed by swimming exercise (SE) in diabetic pregnant rats. This study aims to characterise the role of muscle stem cells (MuSCs), mitochondrial adaptations, and inflammation in this process.Methods: A mild hyperglycaemic pregnant rat model was created by administering 100 mg/kg streptozotocin to Wistar female newborns on the first day of life. In adulthood, after mating, the rats were assigned to either a sedentary or exercise group. The SE protocol involved 60 min of daily swimming, 6 days per week, from gestational day 0 to 20. On gestational day 21, blood samples, rectus abdominis muscle (RAM), and soleus muscle were collected for analysis of fiber type, MuSCs count, mitochondrial adaptations, and inflammation markers.Results: The diabetic group showed a lower number of fast and slow-twitch fibers. SE increased the number of MuSCs, the MuSCs/myonuclei ratio, mitochondrial area, and count, and restored citrate synthase activity. SE also increased the MuSCs/fiber and myonuclei/fiber ratios, as well as the mitochondria number/fiber and mitochondria area/fiber ratios, showing a positive relationship between mitochondrial count and fiber number
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.bbadis.2025.168126
dc.identifier.issn0925-4439
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2025.168126
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107280
dc.information.autorucEscuela de Medicina; Sobrevia Luarte, Luis Alberto; 0000-0001-5802-2243; 1002656
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaBiochimica et Biophysica Molecular Basis of Disease
dc.rightsacceso restringido
dc.subjectDiabetic myopathy
dc.subjectStem cells
dc.subjectMitochondria
dc.subjectSwimming exercise
dc.subjectInflammation
dc.subject.ddc610
dc.titleSwimming exercise attenuates diabetic myopathy and is associated with histological and mitochondrial changes in pregnant rats (Rattus norvegicus)
dc.typeartículo
dc.volumen1872
sipa.codpersvinculados1002656
sipa.trazabilidadORCID;2025-12-01
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