Visible light induced lipoperoxidation of a parenteral nutrition fat emulsion sensitized by flavins

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dc.contributor.authorSilva, E
dc.contributor.authorGonzalez, T
dc.contributor.authorEdwards, AM
dc.contributor.authorZuloaga, F
dc.date.accessioned2024-01-10T12:10:53Z
dc.date.available2024-01-10T12:10:53Z
dc.date.issued1998
dc.description.abstractThe photosensitizing effects of riboflavin, flavin mononucleotide, flavin adenine dinucleotide,and a commercial multivitamin infusate on a lipid emulsion used in parenteral nutrient infusions were studied during exposure to polychromatic visible light. It was found that the efficiency of riboflavin (a polar flavin) as sensitizer of lipid emulsion peroxidation is greater than that of flavin mononucleotide (an ionic flavin). This was determined by measuring the consumption of molecular oxygen and the concentration of thiobarbituric acid-reactive species generated during the irradiation time. These findings are supported by molecular orbital studies of these molecules related to polarity, ionic charges around the different molecular regions, and electrostatic potentials comparisons. Flavin adenine dinucleotide (a more ionic flavin), most likely remains totally excluded from the lipid emulsion due to its polarity and molecular geometry and does not induce lipid peroxidation. The multivitamine complex seems to provide a protective effect on the lipid emulsion exposed to light, attributed to the presence of ascorbic acid, which suffers an intensive photodecomposition. A solution of vitamin C, whose concentration was equivalent to that of the parenteral mixture, consumes an considerable amount of molecular oxygen when it is irradiated with visible light in the presence of flavin mononucleotide. (C) Elsevier Science Inc. 1998.
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0955-2863(97)00177-0
dc.identifier.issn0955-2863
dc.identifier.urihttps://doi.org/10.1016/S0955-2863(97)00177-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76614
dc.identifier.wosidWOS:000072679500005
dc.information.autorucQuímica;Edwards A;S/I;53657
dc.information.autorucQuímica;Silva E;S/I;98771
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final154
dc.pagina.inicio149
dc.publisherELSEVIER SCIENCE INC
dc.revistaJOURNAL OF NUTRITIONAL BIOCHEMISTRY
dc.rightsacceso restringido
dc.subjectflavins
dc.subjectphotosensitized
dc.subjectlipid emulsion
dc.subjectparenteral nutrition infusate
dc.subjectmultivitamin infusate
dc.subjectABSOLUTE ELECTRONEGATIVITY
dc.subjectMAILLARD REACTION
dc.subjectHARDNESS
dc.subjectTRYPTOPHAN
dc.subjectPHOTOPROCESSES
dc.subjectNUTRIENTS
dc.subjectEXPOSURE
dc.subjectTISSUE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVisible light induced lipoperoxidation of a parenteral nutrition fat emulsion sensitized by flavins
dc.typeartículo
dc.volumen9
sipa.codpersvinculados53657
sipa.codpersvinculados98771
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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