Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation

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dc.catalogadoryvc
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorChellappan, D. K.
dc.contributor.authorDureja, H.
dc.contributor.authorDua, K.
dc.contributor.authorRaj Paudel, K. R.
dc.contributor.authorShastri, M. D.
dc.contributor.authorMehta, M.
dc.contributor.authorGulati, M.
dc.contributor.authorHansbro, P.
dc.contributor.authorSingh, S. K.
dc.contributor.authorSatija, S.
dc.contributor.authorShukla, S. D.
dc.date.accessioned2023-08-28T14:04:47Z
dc.date.available2023-08-28T14:04:47Z
dc.date.issued2021
dc.description.abstractAim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells (BEAS-2B) by analysing the expression levels of different antioxidant (NADPH quinine oxidoreductase-1 (NQO1); gamma-glutamyl cysteine synthetase catalytic subunit (GCLC)) and pro-oxidant (NADPH oxidase (Nox)-4; Nox2B) genes. Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress. In addition, these nanoparticles demonstrated an upregulation in the expression of the antioxidant genes Gclc and Nqo-1 in a dose-dependent manner. Conclusion: The study indicates the promising potential of rutin-loaded LCNs as an effective treatment strategy in patients with high oxidant loads in various respiratory diseases.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2023-08-28
dc.fuente.origenHistorial Académico
dc.identifier.citationMehta, M.; Paudel, K. R.; Shukla, S. D. et al. (2021). Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation. Future Medicinal Chemistry. 2021;(13(6)):543-549.
dc.identifier.doi10.4155/fmc-2020-0297
dc.identifier.issn1756-8919
dc.identifier.urihttps://doi.org/10.4155/fmc-2020-0297
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74511
dc.identifier.wosidWOS:000616407600001
dc.information.autorucEscuela de Química ; Zacconi, Flavia C. M. ; 0000-0002-3676-0453 ; 1011127
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final549
dc.pagina.inicio543
dc.revistaFuture Medicinal Chemistryes_ES
dc.rightsacceso restringido
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validationes_ES
dc.typeartículo
dc.volumen13
sipa.codpersvinculados1011127
sipa.indexWoS
sipa.trazabilidadHistorial Académico;21-09-2021
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