ASSOCIATION OF SUBCLINICAL ATHEROSCLEROSIS WITH DIFFERENT STANDARDS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE

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dc.article.numberPO2244
dc.catalogadorpau
dc.contributor.authorArnai, P.
dc.contributor.authorDominguez, Angélica
dc.contributor.authorBarja Y., Salesa
dc.contributor.authorGodoy, I.
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorCastillo Valenzuela, Oscar
dc.contributor.authorFarías Jofré, Marcelo
dc.contributor.authorMardones, Francisco
dc.date.accessioned2023-05-18T19:49:33Z
dc.date.available2023-05-18T19:49:33Z
dc.date.issued2013
dc.description.abstractBackground and objectives: we have previously selected two metabolic syndrome (MS) components blood pressure (BP) and high density lipoprotein cholesterol (HDLC) as associated with carotid intima media thickness (CIMT) a surrogate marker of subclinical atherosclerosis in children (Rev Med Chile 2012; 140: 1268-75). We aimed to ascertain with a higher sample size the influence of the above mentioned variables and three standards defining the MS plus three standards defining insulin resistance (IR). Methods: A cross-sectional study of 447 children 10-14 years old of low socio-economic strata from an urban area of Chile was performed during years 2009-2011. This sample was selected considering the presence of one or more MS component and IR. Anthropometry and BP were assessed. A blood sample for determination of glycaemia, insulinemia (quimioluminiscence) and blood lipids were taken; HOMA was calculated and three standards were applied to select HOMA-IR cases. Three standards to define MS were also used. Medium CIMT was assessed using ultrasonography with automated software. Chi-squared test and stepwise regression were used. Results: Mean age was 11.5 ±1.0 years old; 59% girls; 92.6% pubertal; 72% excess weight. Three standards for MS had prevalence of 24.4% (Cook, 2004), 14.1% (IDF, 2007), 42.9% (De Ferranti, 2004). Three standards for HOMA-IR had the following prevalence: 15.2% (Barja, 2011), 37.4% (Burrows, 2006), 23.0% (De Onis, 2012). Elevated blood pressure and reduced CHDL had significant associations with CIMT ≥ percentile 75. The logistic regression for CIMT ≥ percentile 75 only selected BP ≥ percentile 90 (OR = 2.963) and CHDL < 40 mg/dL (OR = 1.789) Conclusions: None of the various classifications for the MS and the HOMA-IR were selected in the multivariate analysis confirming the previously found influence of increased BP and reduced CHDL on medium CIMT.
dc.format.extent1 página
dc.fuente.origenORCID
dc.identifier.doi10.1159/000354245
dc.identifier.issn0250-6807
dc.identifier.urihttps://doi.org/10.1159/000354245
dc.identifier.urihttps://publons.com/wos-op/publon/20543708/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67046
dc.information.autorucPrograma de Estudios Generales College ; Dominguez, Angélica ; 0000-0001-7477-7574 ; 1239597
dc.information.autorucEscuela de Medicina ; Barja Y., Salesa ; 0000-0001-8583-188X ; 64532
dc.information.autorucEscuela de Medicina ; Villarroel del Pino, Luis A. ; S/I ; 77182
dc.information.autorucEscuela de Medicina ; Castillo Valenzuela, Oscar ; S/I ; 1000391
dc.information.autorucEscuela de Medicina ; Farías Jofré, Marcelo ; 0000-0003-0473-2295 ; 12286
dc.information.autorucEscuela de Medicina ; Mardones, Francisco ; S/I ; 98805
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1341
dc.pagina.inicio1341
dc.revistaAnnals of Nutrition and Metabolism
dc.rightsacceso abierto
dc.subjectMetabolic syndrome
dc.subjectInsulin resistance
dc.subjectCarotid intima-media thickness
dc.subjectChild
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleASSOCIATION OF SUBCLINICAL ATHEROSCLEROSIS WITH DIFFERENT STANDARDS OF THE METABOLIC SYNDROME AND INSULIN RESISTANCE
dc.typeartículo
dc.volumen63
sipa.codpersvinculados1239597
sipa.codpersvinculados64532
sipa.codpersvinculados77182
sipa.codpersvinculados1000391
sipa.codpersvinculados12286
sipa.codpersvinculados98805
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