Abnormal Neural Connectivity in Schizophrenia and fMRI-Brain-Computer Interface as a Potential Therapeutic Approach

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dc.contributor.authorRuiz, S.
dc.contributor.authorBirbaumer, N.
dc.contributor.authorSitaram, Ranganatha
dc.date.accessioned2020-01-14T01:06:49Z
dc.date.available2020-01-14T01:06:49Z
dc.date.issued2013
dc.description.abstractConsidering that single locations of structural and functional abnormalities are insufficient to explain the diverse psychopathology of schizophrenia, new models have postulated that the impairments associated with the disease arise from a failure to integrate the activity of local and distributed neural circuits: the “abnormal neural connectivity hypothesis.” In the last years, new evidence coming from neuroimaging have supported and expanded this theory. However, despite the increasing evidence that schizophrenia is a disorder of neural connectivity, so far there are no treatments that have shown to produce a significant change in brain connectivity, or that have been specifically designed to alleviate this problem. Brain-Computer Interfaces based on real-time functional Magnetic Resonance Imaging (fMRI-BCI) are novel techniques that have allowed subjects to achieve self-regulation of circumscribed brain regions. In recent studies, experiments with this technology have resulted in new findings suggesting that this methodology could be used to train subjects to enhance brain connectivity, and therefore could potentially be used as a therapeutic tool in mental disorders including schizophrenia. The present article summarizes the findings coming from hemodynamics-based neuroimaging that support the abnormal connectivity hypothesis in schizophrenia, and discusses a new approach that could address this problem.
dc.format.extent1 página
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.3389/fpsyt.2013.00017
dc.identifier.issn1664-0640
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27432
dc.identifier.urihttps://doi.org/10.3389/fpsyt.2013.00017
dc.language.isoen
dc.pagina.inicio17
dc.revistaFront Psychiatryes_ES
dc.rightsacceso abierto
dc.subjectBrain self-regulationes_ES
dc.subjectBrain-computer interfaceses_ES
dc.subjectConnectivityes_ES
dc.subjectfMRIes_ES
dc.subjectNeurofeedbackes_ES
dc.subjectSchizophreniaes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleAbnormal Neural Connectivity in Schizophrenia and fMRI-Brain-Computer Interface as a Potential Therapeutic Approaches_ES
dc.typeartículo
dc.volumenVol. 4
sipa.codpersvinculados8459
sipa.codpersvinculados1020541
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