Human papillomavirus-16 presence and physical status in lung carcinomas from Asia

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dc.contributor.authorAguayo González, Francisco
dc.contributor.authorAnwar, Muhammad.
dc.contributor.authorKoriyama, Chihaya.
dc.contributor.authorCastillo, Andres.
dc.contributor.authorSun, Quanfu.
dc.contributor.authorMorewaya, Jacob.
dc.contributor.authorEizuru, Yoshito.
dc.contributor.authorAkiba, Suminori.
dc.date.accessioned2019-10-17T12:42:16Z
dc.date.available2019-10-17T12:42:16Z
dc.date.issued2010
dc.date.updated2019-10-14T18:51:22Z
dc.description.abstractAbstract Background Although human papillomavirus (HPV) genome has been detected in lung cancer, its prevalence is highly variable around the world. Higher frequencies have been reported in far-east Asian countries, when compared with European countries. The present study analysed the HPV-16 presence in 60 lung carcinomas from the Asian countries China, Pakistan and Papua New Guinea. Results HPV-16 was present in 8/59 (13%) samples. According to histological type, HPV-16 was detected in 8/18 (44%) squamous cell carcinomas (SQCs), which were mainly from Pakistan; 0/38 (0%) adenocarcinomas (ACs), which were mainly from China; and in 0/4 (0%) small cell carcinomas (SCLCs). The observed histological difference was statistically significant (p < 0.001). HPV-16 viral load was also determined using real-time polymerase chain reaction (qRT-PCR); it ranged between 411 to 2345 copies/100 ng of genomic DNA. HPV-16 genome was found integrated into the host genome in every HPV-16 positive carcinoma. Conclusion These results support the notion that HPV-16 infection is highly associated with SQCs in Pakistan. Our results show a frequent HPV-16 integration in SQCs, although the low viral load casts doubt respect a direct etiological role of HPV in lung carcinomas from Asia. Additional HPV-16 characterization is necessary to establish a direct or indirect etiological role of HPV in this malignancy.
dc.fuente.origenBiomed Central
dc.identifier.citationInfectious Agents and Cancer. 2010 Nov 16;5(1):20
dc.identifier.doi10.1186/1750-9378-5-20
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26595
dc.issue.numeroNo. 20
dc.language.isoen
dc.pagina.final7
dc.pagina.inicio1
dc.revistaInfectious Agents and Cancer volumees_ES
dc.rightsacceso abierto
dc.rights.holderAguayo et al; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherPulmones - Cánceres_ES
dc.subject.otherGenomases_ES
dc.subject.otherVirus del papiloma humanoes_ES
dc.titleHuman papillomavirus-16 presence and physical status in lung carcinomas from Asiaes_ES
dc.typeartículo
dc.volumenVol. 5
sipa.codpersvinculados1005475
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