A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

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dc.contributor.authorLim, Stephen S.
dc.contributor.authorVos, Theo
dc.contributor.authorFlaxman, Abraham D.
dc.contributor.authorDanaei, Goodarz
dc.contributor.authorShibuya, Kenji
dc.contributor.authorAdair Rohani, Heather
dc.contributor.authorAmann, Markus
dc.contributor.authorAnderson, H. Ross
dc.contributor.authorAndrews, Kathryn G.
dc.contributor.authorAryee, Martin
dc.contributor.authorAtkinson, Charles
dc.contributor.authorBacchus, Loraine J.
dc.contributor.authorBahalim, Adil N.
dc.contributor.authorBalakrishnan, Kalpana
dc.contributor.authorBalmes, John
dc.contributor.authorBarker Collo, Suzanne
dc.contributor.authorBaxter, Amanda
dc.contributor.authorBell, Michelle L.
dc.contributor.authorBlore, Jed D.
dc.contributor.authorBlyth, Fiona
dc.contributor.authorBonner, Carissa
dc.contributor.authorBorges, Guilherme
dc.contributor.authorBourne, Rupert
dc.contributor.authorBoussinesq, Michel
dc.contributor.authorBrauer, Michael
dc.contributor.authorBrooks, Peter
dc.contributor.authorBruce, Nigel G.
dc.contributor.authorBrunekreef, Bert
dc.contributor.authorBryan Hancock, Claire
dc.contributor.authorBucello, Chiara
dc.contributor.authorBuchbinder, Rachelle
dc.contributor.authorBull, Fiona
dc.contributor.authorBurnett, Richard T.
dc.contributor.authorByers, Tim E.
dc.contributor.authorCalabria, Bianca
dc.contributor.authorCarapetis, Jonathan
dc.contributor.authorCarnahan, Emily
dc.contributor.authorChafe, Zoe
dc.contributor.authorCharlson, Fiona
dc.contributor.authorChen, Honglei
dc.contributor.authorChen, Jian Shen
dc.contributor.authorCheng, Andrew Tai Ann
dc.contributor.authorChild, Jennifer Christine
dc.contributor.authorCohen, Aaron
dc.contributor.authorColson, K. Ellicott
dc.contributor.authorCowie, Benjamin C.
dc.contributor.authorDarby, Sarah
dc.contributor.authorDarling, Susan
dc.contributor.authorDavis, Adrian
dc.contributor.authorDegenhardt, Louisa
dc.contributor.authorDentener, Frank
dc.contributor.authorDes Jarlais, Don C.
dc.contributor.authorDevries, Karen
dc.contributor.authorDherani, Mukesh
dc.contributor.authorDing, Eric L.
dc.contributor.authorDorsey, E. Ray
dc.contributor.authorDriscoll, Tim
dc.contributor.authorEdmond, Karen
dc.contributor.authorAli, Suad Eltahir
dc.contributor.authorEngell, Rebecca E.
dc.contributor.authorErwin, Patricia J.
dc.contributor.authorFahimi, Saman
dc.contributor.authorFalder, Gail
dc.contributor.authorFarzadfar, Farshad
dc.contributor.authorFerrari, Alize
dc.contributor.authorFinucane, Mariel M.
dc.contributor.authorFlaxman, Seth
dc.contributor.authorFowkes, Francis Gerry R.
dc.contributor.authorFreedman, Greg
dc.contributor.authorFreeman, Michael K.
dc.contributor.authorGakidou, Emmanuela
dc.contributor.authorGhosh, Santu
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorGmel, Gerhard
dc.contributor.authorGraham, Kathryn
dc.contributor.authorGrainger, Rebecca
dc.contributor.authorGrant, Bridget
dc.contributor.authorGunnell, David
dc.contributor.authorGutierrez, Hialy R.
dc.contributor.authorHall, Wayne
dc.contributor.authorHoek, Hans W.
dc.contributor.authorHogan, Anthony
dc.contributor.authorHosgood, H. Dean, III
dc.contributor.authorHoy, Damian
dc.contributor.authorHu, Howard
dc.contributor.authorHubbell, Bryan J.
dc.contributor.authorHutchings, Sally J.
dc.contributor.authorIbeanusi, Sydney E.
dc.contributor.authorJacklyn, Gemma L.
dc.contributor.authorJasrasaria, Rashmi
dc.contributor.authorJonas, Jost B.
dc.contributor.authorKan, Haidong
dc.contributor.authorKanis, John A.
dc.contributor.authorKassebaum, Nicholas
dc.contributor.authorKawakami, Norito
dc.contributor.authorKhang, Young Ho
dc.contributor.authorKhatibzadeh, Shahab
dc.contributor.authorKhoo, Jon Paul
dc.contributor.authorKok, Cindy
dc.contributor.authorLaden, Francine
dc.contributor.authorLalloo, Ratilal
dc.contributor.authorLan, Qing
dc.contributor.authorLathlean, Tim
dc.contributor.authorLeasher, Janet L.
dc.contributor.authorLeigh, James
dc.contributor.authorLi, Yang
dc.contributor.authorLin, John Kent
dc.contributor.authorLipshultz, Steven E.
dc.contributor.authorLondon, Stephanie
dc.contributor.authorLozano, Rafael
dc.contributor.authorLu, Yuan
dc.contributor.authorMak, Joelle
dc.contributor.authorMalekzadeh, Reza
dc.contributor.authorMallinger, Leslie
dc.contributor.authorMarcenes, Wagner
dc.contributor.authorMarch, Lyn
dc.contributor.authorMarks, Robin
dc.contributor.authorMartin, Randall
dc.contributor.authorMcGale, Paul
dc.contributor.authorMcGrath, John
dc.contributor.authorMehta, Sumi
dc.contributor.authorMensah, George A.
dc.contributor.authorMerriman, Tony R.
dc.contributor.authorMicha, Renata
dc.contributor.authorMichaud, Catherine
dc.contributor.authorMishra, Vinod
dc.contributor.authorHanafiah, Khayriyyah Mohd
dc.contributor.authorMokdad, Ali A.
dc.contributor.authorMorawska, Lidia
dc.contributor.authorMozaffarian, Dariush
dc.contributor.authorMurphy, Tasha
dc.contributor.authorNaghavi, Mohsen
dc.contributor.authorNeal, Bruce
dc.contributor.authorNelson, Paul K.
dc.contributor.authorMiquel Nolla, Joan
dc.contributor.authorNorman, Rosana
dc.contributor.authorOlives, Casey
dc.contributor.authorOmer, Saad B.
dc.contributor.authorOrchard, Jessica
dc.contributor.authorOsborne, Richard
dc.contributor.authorOstro, Bart
dc.contributor.authorPage, Andrew
dc.contributor.authorPandey, Kiran D.
dc.contributor.authorParry, Charles D. H.
dc.contributor.authorPassmore, Erin
dc.contributor.authorPatra, Jayadeep
dc.contributor.authorPearce, Neil
dc.contributor.authorPelizzari, Pamela M.
dc.contributor.authorPetzold, Max
dc.contributor.authorPhillips, Michael R.
dc.contributor.authorPope, Dan
dc.contributor.authorPope, C. Arden, III
dc.contributor.authorPowles, John
dc.contributor.authorRao, Mayuree
dc.contributor.authorRazavi, Homie
dc.contributor.authorRehfuess, Eva A.
dc.contributor.authorRehm, Juergen T.
dc.contributor.authorRitz, Beate
dc.contributor.authorRivara, Frederick P.
dc.contributor.authorRoberts, Thomas
dc.contributor.authorRobinson, Carolyn
dc.contributor.authorRodriguez Portales, Jose A.
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorRoom, Robin
dc.contributor.authorRosenfeld, Lisa C.
dc.contributor.authorRoy, Ananya
dc.contributor.authorRushton, Lesley
dc.contributor.authorSalomon, Joshua A.
dc.contributor.authorSampson, Uchechukwu
dc.contributor.authorSanchez Riera, Lidia
dc.contributor.authorSanman, Ella
dc.contributor.authorSapkota, Amir
dc.contributor.authorSeedat, Soraya
dc.contributor.authorShi, Peilin
dc.contributor.authorShield, Kevin
dc.contributor.authorShivakoti, Rupak
dc.contributor.authorSingh, Gitanjali M.
dc.contributor.authorSleet, David A.
dc.contributor.authorSmith, Emma
dc.contributor.authorSmith, Kirk R.
dc.contributor.authorStapelberg, Nicolas J. C.
dc.contributor.authorSteenland, Kyle
dc.contributor.authorStoeckl, Heidi
dc.contributor.authorStovner, Lars Jacob
dc.contributor.authorStraif, Kurt
dc.contributor.authorStraney, Lahn
dc.contributor.authorThurston, George D.
dc.contributor.authorTran, Jimmy H.
dc.contributor.authorVan Dingenen, Rita
dc.contributor.authorvan Donkelaar, Aaron
dc.contributor.authorVeerman, J. Lennert
dc.contributor.authorVijayakumar, Lakshmi
dc.contributor.authorWeintraub, Robert
dc.contributor.authorWeissman, Myrna M.
dc.contributor.authorWhite, Richard A.
dc.contributor.authorWhiteford, Harvey
dc.contributor.authorWiersma, Steven T.
dc.contributor.authorWilkinson, James D.
dc.contributor.authorWilliams, Hywel C.
dc.contributor.authorWilliams, Warwick
dc.contributor.authorWilson, Nicholas
dc.contributor.authorWoolf, Anthony D.
dc.contributor.authorYip, Paul
dc.contributor.authorZielinski, Jan M.
dc.contributor.authorLopez, Alan D.
dc.contributor.authorMurray, Christopher J. L.
dc.contributor.authorEzzati, Majid
dc.date.accessioned2024-01-10T12:04:06Z
dc.date.available2024-01-10T12:04:06Z
dc.date.issued2012
dc.description.abstractBackground Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time.
dc.description.abstractMethods We estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010. We estimated exposure distributions for each year, region, sex, and age group, and relative risks per unit of exposure by systematically reviewing and synthesising published and unpublished data. We used these estimates, together with estimates of cause-specific deaths and DALYs from the Global Burden of Disease Study 2010, to calculate the burden attributable to each risk factor exposure compared with the theoretical-minimum-risk exposure. We incorporated uncertainty in disease burden, relative risks, and exposures into our estimates of attributable burden.
dc.description.abstractFindings In 2010, the three leading risk factors for global disease burden were high blood pressure (7.0% [95% uncertainty interval 6.2-7.7] of global DALYs), tobacco smoking including second-hand smoke (6.3% [5.5-7.0]), and alcohol use (5.5% [5.0-5.9]). In 1990, the leading risks were childhood underweight (7.9% [6.8-9.4]), household air pollution from solid fuels (HAP; 7.0% [5.6-8.3]), and tobacco smoking including second-hand smoke (6.1% [5.4-6.8]). Dietary risk factors and physical inactivity collectively accounted for 10.0% (95% UI 9.2-10.8) of global DALYs in 2010, with the most prominent dietary risks being diets low in fruits and those high in sodium. Several risks that primarily affect childhood communicable diseases, including unimproved water and sanitation and childhood micronutrient deficiencies, fell in rank between 1990 and 2010, with unimproved water and sanitation accounting for 0.9% (0.4-1.6) of global DALYs in 2010. However, in most of sub-Saharan Africa childhood underweight, HAP, and non-exclusive and discontinued breastfeeding were the leading risks in 2010, while HAP was the leading risk in south Asia. The leading risk factor in Eastern Europe, most of Latin America, and southern sub-Saharan Africa in 2010 was alcohol use; in most of Asia, North Africa and Middle East, and central Europe it was high blood pressure. Despite declines, tobacco smoking including second-hand smoke remained the leading risk in high-income north America and western Europe. High body-mass index has increased globally and it is the leading risk in Australasia and southern Latin America, and also ranks high in other high-income regions, North Africa and Middle East, and Oceania.
dc.description.abstractInterpretation Worldwide, the contribution of different risk factors to disease burden has changed substantially, with a shift away from risks for communicable diseases in children towards those for non-communicable diseases in adults. These changes are related to the ageing population, decreased mortality among children younger than 5 years, changes in cause-of-death composition, and changes in risk factor exposures. New evidence has led to changes in the magnitude of key risks including unimproved water and sanitation, vitamin A and zinc deficiencies, and ambient particulate matter pollution. The extent to which the epidemiological shift has occurred and what the leading risks currently are varies greatly across regions. In much of sub-Saharan Africa, the leading risks are still those associated with poverty and those that affect children.
dc.description.funderLundbeck
dc.description.funderPrana Biotechnology
dc.description.funderAbbott
dc.description.funderAmgen
dc.description.funderAstraZeneca
dc.description.funderGeorge Clinical
dc.description.funderGlaxoSmithKline
dc.description.funderNovartis
dc.description.funderPepsiCo
dc.description.funderPfizer
dc.description.funderPharmacy Guild of Australia
dc.description.funderRoche
dc.description.funderSanofi-Aventis
dc.description.funderSeervier
dc.description.funderTanabe
dc.description.funderAustralian Food and Grocery Council
dc.description.funderBupa Australia
dc.description.funderJohnson and Johnson
dc.description.funderMerck Schering-Plough
dc.description.funderServier
dc.description.funderUnited Healthcare Group
dc.description.funderImperial College London (as PI) from the European Chemical Industry Council
dc.description.funderCONCAWE
dc.description.funderUSEPA
dc.description.funderShell Foundation
dc.description.funderFight for Sight
dc.description.funderAustralian National Health and Medical Research Council
dc.description.funderMonash University
dc.description.funderCabrini Health
dc.description.funderHealth Effects Institute
dc.description.funderWilliam and Flora Hewlett Foundation
dc.description.funderCancer Research UK
dc.description.funderSafework Australia
dc.description.funderJohns Hopkins Vaccine Initiative Scholarship
dc.description.funderWHO
dc.description.funderParnassia Psychiatric Institute, The Hague, Netherlands
dc.description.funderDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Netherlands
dc.description.funderWorld Mental Health Japan
dc.description.funderGrant for Research on Psychiatric and Neurological Diseases and Mental Health from the Japan Ministry of Health, Labour, and Welfare
dc.description.funderIntramural Research Program of the NIH (National Cancer Institute)
dc.description.funderDivision of Intramural Research, National Institute of Environmental Health Sciences, USA
dc.description.funderAustralian Research Council Future Fellowship
dc.description.funderNational Health and Medical Research Council of Australia Senior Research Fellowship
dc.description.funderMunich Centre of Health Sciences
dc.description.funderFoundation for Alcohol Research and Education
dc.description.funderVictorian Department of Health
dc.description.funderBurke Global Health Fellowship
dc.description.funderHarold Amos Medical Faculty Development Award of the Robert Wood Johnson Foundation
dc.description.funderVanderbilt Clinical and Translational Scholars Award
dc.description.funderSpanish Society of Rheumatology
dc.description.funderSouth African Research Chairs Initiative
dc.description.funderNational Research Foundation
dc.description.funderNational Institute of Environmental Health Sciences
dc.description.funderUK Medical Research Council (MRC)
dc.description.funderNational Institute for Health Research Comprehensive Biomedical research Centre at Imperial College Healthcare NHS Trust
dc.description.funderNutrition Impact Model Study (NIMS)
dc.description.funderBill & Melinda Gates Foundation
dc.description.funderSpanish Rheumatology Association
dc.description.funderInstitute of Bone and Joint Research
dc.description.funderUniversity of Sydney
dc.description.funderMedical Research Council
dc.description.funderGrants-in-Aid for Scientific Research
dc.description.funderNATIONAL CANCER INSTITUTE
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.description.funderNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
dc.description.funderNATIONAL INSTITUTE ON AGING
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent37 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0140-6736(12)61766-8
dc.identifier.eissn1474-547X
dc.identifier.issn0140-6736
dc.identifier.pubmedidMEDLINE:23245609
dc.identifier.urihttps://doi.org/10.1016/S0140-6736(12)61766-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75685
dc.identifier.wosidWOS:000312387000017
dc.information.autorucMedicina;Rodriguez J;S/I;98660
dc.issue.numero9859
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final2260
dc.pagina.inicio2224
dc.publisherELSEVIER SCIENCE INC
dc.revistaLANCET
dc.rightsacceso restringido
dc.subjectCORONARY-HEART-DISEASE
dc.subjectLUNG-CANCER RISK
dc.subjectFINE PARTICULATE MATTER
dc.subjectLONG-TERM EXPOSURE
dc.subjectBODY-MASS INDEX
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectAIR-POLLUTION
dc.subjectALCOHOL-CONSUMPTION
dc.subjectBLOOD-PRESSURE
dc.subjectCOLLABORATIVE ANALYSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.ods11 Sustainable Cities and Communities
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.titleA comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
dc.typeartículo
dc.volumen380
sipa.codpersvinculados98660
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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