Screen-detected breast cancer is associated with better prognosis and survival compared to self-detected/symptomatic cases in a Chilean cohort of female patients

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dc.catalogadorpva
dc.contributor.authorWalbaum, Benjamin
dc.contributor.authorPuschel, Klaus
dc.contributor.authorMedina, Lidia
dc.contributor.authorMerino, Tomas
dc.contributor.authorCamus, Mauricio
dc.contributor.authorRazmilic, Dravna
dc.contributor.authorNavarro, Maria Elena
dc.contributor.authorDominguez, Francisco
dc.contributor.authorCordova‑Delgado, Miguel
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorAcevedo, Francisco
dc.contributor.authorSánchez, César
dc.date.accessioned2024-01-19T18:21:49Z
dc.date.available2024-01-19T18:21:49Z
dc.date.issued2021
dc.description.abstractPurpose The implementation of national breast cancer (BC) screening programs in Latin America has been rather inconsistent. Instead, most countries have opted for “opportunistic” mammogram screenings on the population at risk. Our study assessed and compared epidemiological, clinical factors, and survival rates associated with BC detected by screening (SDBC) or self-detected/symptomatic (non-SDBC) in Chilean female patients. Methods Registry-based cohort study that included non-metastatic BC (stage I/II/III) patients diagnosed between 1993 and 2020, from a public hospital (PH) and a private university cancer center (PC). Epidemiological and clinical data were obtained from medical records. Results A total of 4559 patients were included. Most patients (55%; n = 2507) came from PH and were diagnosed by signs/ symptoms (non-SDBC; n = 3132, 68.6%); these patients displayed poorer overall (OS) and invasive disease-free survival (iDFS) compared to SDBC. Importantly, the proportion of stage I and “luminal” BC (HR + /HER2 −) were significantly higher in SDBC vs. non-SDBC. Finally, using a stage/subset-stratified age/insurance-adjusted model, we found that nonSDBC cases are at a higher risk of death (HR:1.75; p < 0.001). In contrast, patients with PC health insurance have a lower risk of death (HR: 0.60; p < 0.001). Conclusion We confirm previous studies that report better prognosis/survival on SDBC patients. This is probably due to a higher proportion of stage I and luminal-A cases versus non-SDBC. In turn, the survival benefit observed in patients with PC health insurance might be attributed to a larger proportion of SDBC. Our data support the implementation of a systematic BC screening program in Chile to improve patient prognosis and survival rates.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1007/s10549-021-06317-1
dc.identifier.urihttp://dx.doi.org/10.1007/s10549-021-06317-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80801
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolas; 0000-0003-3482-7746; 119540
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final569
dc.pagina.inicio561
dc.revistaBreast Cancer Research and Treatment
dc.rightsacceso restringido
dc.subjectScreening
dc.subjectChilean public health system
dc.subjectBreast cancer
dc.subjectSubtype
dc.subjectStage
dc.subjectAnd overall survival
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleScreen-detected breast cancer is associated with better prognosis and survival compared to self-detected/symptomatic cases in a Chilean cohort of female patients
dc.typeartículo
dc.volumen189
sipa.codpersvinculados119540
sipa.trazabilidadORCID;2024-01-08
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