Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy

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dc.article.number21145
dc.catalogadorpva
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorWalbaum García, Benjamín Vicente
dc.contributor.authorMuñiz Muñoz, María Sabrina
dc.contributor.authorPetric Guajardo, Militza Paulina
dc.contributor.authorMartínez, Raúl
dc.contributor.authorGuerra, Constanza
dc.contributor.authorNavarro, Marisel
dc.contributor.authorCórdova Delgado, Miguel
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorSánchez Rojel, César Giovanni
dc.date.accessioned2024-01-19T18:21:52Z
dc.date.available2024-01-19T18:21:52Z
dc.date.issued2022
dc.description.abstractPathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is associated with good long-term prognosis in breast cancer (BC) patients. However, some patients still recur and eventually die from this disease. For years, clinical stage at diagnosis has been consistently linked to recurrence and survival in the pCR setting. Herein, we aimed to identify other potential predictors of recurrence and survival in patients that achieved pCR. We performed a retrospective analysis of patients diagnosed between 2011 and 2020 in our center. We calculated overall survival (OS), invasive disease-free survival (IDFS), distant disease-free survival (DDFS), and BC-specific survival (BCSS). Among the 241 patients included into our study 36% were obese (Body Mass Index (BMI) > 29.9 kg/m2) and 47% were stage III. Multivariate analysis confirmed that obesity was a significant risk factor associated with early recurrence and poorer survival in these patients. In summary, obesity and clinical stage predict early recurrence and poorer survival in patients that achieved pCR after NCT. Pending further investigation and based on our findings we speculate that weight management could be beneficial for this subset of patients. To our knowledge, this is the first Latin American report linking obesity and recurrence within this setting.
dc.fechaingreso.objetodigital2024-01-10
dc.format.extent8 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1038/s41598-022-25043-2
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-022-25043-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80823
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolas; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Walbaum García, Benjamín Vicente; 0000-0003-2314-5360; 163702
dc.information.autorucEscuela de Medicina; Muñiz Muñoz, María Sabrina; S/I; 1023831
dc.information.autorucEscuela de Medicina; Petric Guajardo, Militza Paulina; S/I; 218626
dc.information.autorucEscuela de Medicina; Sánchez Rojel, César Giovanni; 0000-0002-2920-108X; 135644
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaScientific Reports
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleObesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy
dc.typeartículo
dc.volumen12
sipa.codpersvinculados119540
sipa.codpersvinculados163702
sipa.codpersvinculados1023831
sipa.codpersvinculados218626
sipa.codpersvinculados135644
sipa.trazabilidadORCID;2024-01-08
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