Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer

Simple item page
dc.article.number234
dc.catalogadoraba
dc.contributor.authorPérez Moreno, Pablo
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorGarcía Cañete, Patricia
dc.contributor.authorBrebi, Priscilla
dc.contributor.authorRoa, Juan Carlos
dc.date.accessioned2023-08-11T22:05:39Z
dc.date.available2023-08-11T22:05:39Z
dc.date.issued2022
dc.description.abstractGallbladder cancer (GBC) is an aggressive neoplasm that in an early stage is generally asymptomatic and, in most cases, is diagnosed in advanced stages with a very low life expectancy because there is no curative treatment. Therefore, understanding the early carcinogenic mechanisms of this pathology is crucial to proposing preventive strategies for this cancer. The main risk factor is the presence of gallstones, which are associated with some environmental factors such as a sedentary lifestyle and a high-fat diet. Other risk factors such as autoimmune disorders and bacterial, parasitic and fungal infections have also been described. All these factors can generate a long-term inflammatory state characterized by the persistent activation of the immune system, the frequent release of pro-inflammatory cytokines, and the constant production of reactive oxygen species that result in a chronic damage/repair cycle, subsequently inducing the loss of the normal architecture of the gallbladder mucosa that leads to the development of GBC. This review addresses how the different risk factors could promote a chronic inflammatory state essential to the development of gallbladder carcinogenesis, which will make it possible to define some strategies such as anti-inflammatory drugs or public health proposals in the prevention of GBC.
dc.fechaingreso.objetodigital2024-06-05
dc.format.extent22 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/jpm12020234
dc.identifier.eissn2075-4426
dc.identifier.urihttps://doi.org/10.3390/jpm12020234
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74390
dc.information.autorucEscuela de Medicina; García Cañete, Patricia; 0000-0002-3817-4896; 73909
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final22
dc.pagina.inicio1
dc.revistaJournal of Personalized Medicine
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectGallbladder canceres_ES
dc.subjectRisk factorses_ES
dc.subjectCarcinogenesises_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleEnvironmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Canceres_ES
dc.titleEnvironmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer
dc.typeartículo
dc.volumen12
sipa.codpersvinculados73909
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
environmentalandlifestyle.pdf
Size:
5.69 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas