Abstract MP11: Striatin Heterozygous Knockout Mice Have Increased Aldosterone Sensitivity
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Date
2015
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Abstract
Background: We recently demonstrated that mice lacking one copy of the striatin gene (Strn+/-) have salt sensitivity of blood pressure (BP) as compared with WT mice. To determine whether Strn+/- mice have increased sensitivity to aldosterone (ALDO), we assessed the effect on blood pressure of an ALDO infusion in WT and Strn+/- mice fed a liberal sodium diet.
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Keywords
Blood pressure, Renal function, Genetics