Evidence for a polarized Th1 response in the maternal circulation in women with preterm labor and intra-amniotic inflammation/infection

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dc.article.number131
dc.catalogadorpau
dc.contributor.authorEspinoza, Jimmy
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorHassan, Sonia
dc.contributor.authorEdwin, Samuel S.
dc.contributor.authorGotsch, Francesca
dc.contributor.authorKim, Chong Jai
dc.contributor.authorThan, Nandor Gabor
dc.contributor.authorErez, Offer
dc.contributor.authorNien, Jyh Kae
dc.contributor.authorGómez Mora, Ricardo Alberto
dc.contributor.authorYoon, Bo Hyun
dc.contributor.authorRomer, Roberto
dc.date.accessioned2023-07-21T17:46:05Z
dc.date.available2023-07-21T17:46:05Z
dc.date.issued2006
dc.description.abstractOBJECTIVE: Most work examining the immune response to intra-amniotic infection has focused on the study of amniotic fluid (AF) cytokines. An adequate characterization of the full range of maternal pro- and antiinflammatory cytokines is lacking. This is important, because of emerging evidence that complications of infection result from an anti-inflammatory response. The purpose of this study was to characterize the maternal cytokine response in women with preterm labor with and without intra-amniotic infection/inflammation (IAI). STUDY DESIGN: This study focused on patients with preterm labor in the following groups: 1) term delivery (n = 157); 2) preterm delivery without IAI (n = 126); and 3) IAI (n = 50). IAI was defined as a positive AF culture or an elevated AF WBC count. Maternal plasma concentrations of interleukin (IL)-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, interferon gamma, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha were determined. A p!0.05 was considered significant. RESULTS: 1) Patients with IAI had higher plasma concentrations of IL-6 than those without IAI who delivered preterm [median: 12.5 pg/ml, range: 0-355.5 vs.7.4 pg/ml, range: 0.74-179.3; p = 0.04), and those who delivered at term (median: 5 pg/ml, range: 0-541.4; p = 0.01); 2) Patients with IAI had higher plasma concentrations of IL-8 than those who delivered at term (median:11.1 pg/ml, range: 0.29-82 vs. median: 6 pg/ml, range: 0.4-84.3; p = 0.02) but not than those without IAI who delivered preterm (median: 7.9, range: 1.3-90.2; pO0.05); and 3) There were no significant differences in the plasma concentrations of the rest of the cytokines (11 of 13) among groups. CONCLUSION: IL6 and IL8 are increased in the maternal circulation in cases of intra-amniotic infection/inflammation. The lack of a demonstrable anti-inflammatory response is in sharp contrast to what has been reported in non-pregnant patients
dc.format.extent1 página
dc.fuente.origenORCID
dc.identifier.doi10.1016/J.AJOG.2006.10.148
dc.identifier.issn0020-7292
dc.identifier.urihttp://dx.doi.org/10.1016/J.AJOG.2006.10.148
dc.identifier.urihttps://publons.com/wos-op/publon/19879828/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74232
dc.information.autorucEscuela de Medicina; Gómez Mora, Ricardo Alberto; 0000-0001-9267-304X; 80926
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final51
dc.pagina.inicio51
dc.relation.ispartof(27° ; 2007 ; San Francisco, Estados Unidos)
dc.revistaAmerican Journal of Obstetrics and Gynecologyes_ES
dc.rightsacceso restringido
dc.titleEvidence for a polarized Th1 response in the maternal circulation in women with preterm labor and intra-amniotic inflammation/infectiones_ES
dc.typecomunicación de congreso
dc.volumen195
sipa.codpersvinculados80926
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