Pathological complete response to neoadjuvant chemotherapy, but not the addition of carboplatin, is associated with improved survival in Chilean triple negative breast cancer patients: a report of real world data

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dc.article.number1178
dc.catalogadorpva
dc.contributor.authorWalbaum, Benjamin
dc.contributor.authorAcevedo, Francisco
dc.contributor.authorMedian, Lidia
dc.contributor.authorBravo, M. Loreto
dc.contributor.authorMerino, Tomas
dc.contributor.authorCamus, Mauricio
dc.contributor.authorDominguez, Francisco
dc.contributor.authorMondaca, Sebastián
dc.contributor.authorGalindo, Héctor
dc.contributor.authorNervi, Bruno
dc.contributor.authorIbañez, Carolina
dc.contributor.authorMadrid, Jorge
dc.contributor.authorMuñiz, Sabrina
dc.contributor.authorPeña, José
dc.contributor.authorKoch, Érica
dc.contributor.authorGarrido, Marcelo
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorSánchez, César
dc.date.accessioned2024-01-19T18:21:50Z
dc.date.available2024-01-19T18:21:50Z
dc.date.issued2021
dc.description.abstractBackground: Breast cancer (BC) is the leading cause of cancer death for Chilean women. About 11% of cases are triple-negative (TN) BC. These are characterised by poor prognosis, higher risk of early recurrence and visceral dissemination versus other BC subtypes. Current standard treatment for early-stage non-metastatic TNBC patients consists of neoadjuvant chemotherapy (NACT) followed by surgery and radiotherapy. Pathological complete response (pCR) to NACT is associated with an increase in survival rates. In general, NACT and adjuvant regimens involve similar cytotoxic drugs. Recent studies have postulated that the use of platinum compounds in TNBC would increase response rates. However, their effects on patient survival remain uncertain. Materials and methods: We retrieved and analysed medical records from a total of 156 Chilean stage I–III TNBC female patients that received NACT and compared survival rates using carboplatin (Cb)-containing versus non-Cb-containing regimens at two health cancer centres. Results: Median age was 51 years (range: 24–81); 13.5% (n = 21) received Cb-containing regimens, 80.1% (n = 125) received sequential anthracyclines plus taxanes; 29.5% (n = 46) of the total group achieved pCR, 28% for the standard treatment and 35% (n = 8) for the Cb-containing group (p = 0.59). We confirmed pCR was associated with prolonged overall survival, invasive and distant disease-free survival (Log-rank p = 0.0236). But the addition of Cb was not associated with differences in survival measures (Log-rank p = 0.5216). Conclusions: To the best of authors’ knowledge, this is the first report on real-world data in the Chilean population assessing the effect of Cb-containing NACT in TNBC. The authors’ results suggest no survival benefit by the addition of Cb to standard NACT. However, we confirm an increase in survival associated to pCR regardless of treatment.
dc.fechaingreso.objetodigital2024-06-05
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3332/ecancer.2021.1178
dc.identifier.urihttp://dx.doi.org/10.3332/ecancer.2021.1178
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80807
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolas; 0000-0003-3482-7746; 119540
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final15
dc.pagina.inicio10
dc.revistaecancer
dc.rightsacceso abierto
dc.rights.licenseCC BY 3.0 DEED Attribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectBreast neoplasm
dc.subjectTriple negative
dc.subjectNeoadjuvant
dc.subjectChemotherapy
dc.subjectCarboplatin
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePathological complete response to neoadjuvant chemotherapy, but not the addition of carboplatin, is associated with improved survival in Chilean triple negative breast cancer patients: a report of real world data
dc.typeartículo
dc.volumen1
sipa.codpersvinculados119540
sipa.trazabilidadORCID;2024-01-08
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