Demographic and clinical risk factors associated with severity of lab-confirmed human leptospirosis in Colombia, 2015–2020

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dc.article.numbere0011454
dc.catalogadorpva
dc.contributor.authorParra Barrera, Eliana Liseth
dc.contributor.authorBello Piruccini, Solmara
dc.contributor.authorRodríguez, Karina
dc.contributor.authorDuarte, Carolina
dc.contributor.authorTorres Hidalgo, Marisa
dc.contributor.authorUndurraga, Eduardo A.
dc.date.accessioned2024-01-08T17:07:49Z
dc.date.available2024-01-08T17:07:49Z
dc.date.issued2023
dc.description.abstractLeptospirosis is a neglected tropical disease and a public health concern worldwide. Infection in humans usually occurs through direct or indirect contact with the urine of infected animals. Most leptospirosis cases are mild, but between 5–15% of cases can be severe and even fatal, primarily due to delays in diagnosis, misrecognition, inadequate treatment, or pathogenicity of some strains. The factors associated with severity could be used to support triaging and avoid preventable medical complications or death. Colombia is an endemic country for leptospirosis, with mandatory laboratory surveillance. Our objective was to determine the demographic and clinical risk factors associated with severe leptospirosis. We used a unique dataset of 201 lab-confirmed leptospirosis cases notified to the National Reference Laboratory with a reported clinical history from several regions in Colombia. The cases presented severe illness (43.3%), ICU admission (30.3%), and fatal (8.5%). Severe leptospirosis was associated with dyspnea, tachycardia, and rash; fatal cases were associated with jaundice. We hope these results raise awareness among healthcare workers and support clinicians in avoiding preventable medical complications or death in human leptospirosis in Colombia and elsewhere.
dc.fechaingreso.objetodigital2024-01-08
dc.fuente.origenWOS
dc.identifier.doi10.1371/journal.pntd.0011454
dc.identifier.issn1935-2735
dc.identifier.urihttps://doi.org/10.1371/journal.pntd.0011454
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75648
dc.identifier.wosidWOS:001023911300004
dc.information.autorucEscuela de Medicina; Parra Barrera, Eliana Liseth; 0000-0002-2745-7997; 1139372
dc.information.autorucEscuela de Medicina; Torres Hidalgo, Marisa; 0000-0002-9027-8828; 71397
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio1
dc.publisherPUBLIC LIBRARY SCIENCE
dc.revistaPlos Neglected Tropical Deseaseses_ES
dc.rightsacceso abierto
dc.subjectLeptospirosises_ES
dc.subjectSeverityes_ES
dc.subjectNeglected tropical diseaseses_ES
dc.subjectRisk factores_ES
dc.subjectMortalityes_ES
dc.subjectColombiaes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDemographic and clinical risk factors associated with severity of lab-confirmed human leptospirosis in Colombia, 2015–2020es_ES
dc.typeartículo
dc.volumen17
sipa.codpersvinculados1139372
sipa.codpersvinculados71397
sipa.trazabilidadWOS;2023-08-15
sipa.trazabilidadORCID;2024-01-08
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