Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid

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dc.contributor.authorAkl, Elie A.
dc.contributor.authorSun, Xin
dc.contributor.authorBusse, Jason W.
dc.contributor.authorJohnston, Bradley C.
dc.contributor.authorBriel, Matthias
dc.contributor.authorMulla, Sohail
dc.contributor.authorYou, John J.
dc.contributor.authorBassler, Dirk
dc.contributor.authorLamontagne, Francois
dc.contributor.authorVera, Claudio
dc.contributor.authorAlshurafa, Mohamad
dc.contributor.authorKatsios, Christina M.
dc.contributor.authorHeels Ansdell, Diane
dc.contributor.authorZhou, Qi
dc.contributor.authorMills, Ed
dc.contributor.authorGuyatt, Gordon H.
dc.date.accessioned2024-01-10T12:42:53Z
dc.date.available2024-01-10T12:42:53Z
dc.date.issued2012
dc.description.abstractObjective: To test the reliability and validity of specific instructions to classify blinding, when unclearly reported in randomized trials, as "probably done" or "probably not done."
dc.description.abstractStudy Design and Setting: We assessed blinding of patients, health care providers, data collectors, outcome adjudicators, and data analysts in 233 randomized trials in duplicate and independently using detailed instructions. The response options were "definitely yes," "probably yes," "probably no," and "definitely no." We contacted authors for data verification (46% response). For each of the five questions, we assessed reliability by calculating the agreement between the two reviewers and validity by calculating the agreement between reviewers' consensus and verified data.
dc.description.abstractResults: The percentage with unclear blinding status varied between 48.5% (patients) and 84.1% (data analysts). Reliability was moderate for blinding of outcome adjudicators (kappa = 0.52) and data analysts (kappa = 0.42) and substantial for blinding of patients (kappa = 0.71), providers (kappa = 0.68), and data collectors (kappa = 0.65). The raw agreement between the consensus record and the author-verified record varied from 84.1% (blinding of data analysts) to 100% (blinding of health care providers).
dc.description.abstractConclusion: With the possible exception of blinding of data analysts, use of "probably yes" and "probably no" instead of "unclear" may enhance the assessment of blinding in trials. (C) 2012 Elsevier Inc. All rights reserved.
dc.description.funderPfizer, Inc.
dc.description.funderSwiss National Science Foundation
dc.description.funderRoche Research Foundation
dc.description.funderOntario Ministry of Health and Long-Term Care
dc.description.funderNational Natural Science Foundation of China
dc.description.funderSickKids Foundation
dc.description.funderCanadian Institutes of Health Research
dc.description.funderCanadian Chiropractic Research Foundation
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jclinepi.2011.04.015
dc.identifier.eissn1878-5921
dc.identifier.issn0895-4356
dc.identifier.pubmedidMEDLINE:22200346
dc.identifier.urihttps://doi.org/10.1016/j.jclinepi.2011.04.015
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77549
dc.identifier.wosidWOS:000299754800007
dc.information.autorucMedicina;Vera C ;S/I;687
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final267
dc.pagina.inicio262
dc.publisherELSEVIER SCIENCE INC
dc.revistaJOURNAL OF CLINICAL EPIDEMIOLOGY
dc.rightsacceso restringido
dc.subjectMethods
dc.subjectResearch design
dc.subjectBias
dc.subjectRandomized controlled trial
dc.subjectSystematic review
dc.subjectClinical practice guideline
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSpecific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid
dc.typeartículo
dc.volumen65
sipa.codpersvinculados687
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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