High Risk of Coronary Artery Aneurysms in Infants Younger than 6 Months of Age with Kawasaki Disease

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dc.contributor.authorSalgado, Andrea P.
dc.contributor.authorAshouri, Negar
dc.contributor.authorBerry, Erika K.
dc.contributor.authorSun, Xiaoying
dc.contributor.authorJain, Sonia
dc.contributor.authorBurns, Jane C.
dc.contributor.authorTremoulet, Adriana H.
dc.date.accessioned2024-01-10T12:05:50Z
dc.date.available2024-01-10T12:05:50Z
dc.date.issued2017
dc.description.abstractObjectives To characterize the clinical presentation and outcome in infants <6 months of age with Kawasaki disease (KD) and to describe the use of newer anti-inflammatory therapies in this young population.
dc.description.abstractStudy design We evaluated 88 infants <6 months old and 632 >= 6 months old treated for KD. We compared differences in laboratory data, response to treatment, and coronary artery outcomes between the 2 cohorts. Fisher exact test was used to analyze categorical variables, whereas the Wilcoxon rank sum test was used for continuous variables.
dc.description.abstractResults The majority of children in both cohorts were diagnosed and treated within the first 10 days of illness (median illness day 6 in both cohorts). For patients treated within the first 10 days after fever onset, a larger proportion of infants <6 months old had a dilated or aneurysmal coronary artery on the initial echocardiogram compared with those >= 6 months old (43.4% vs 19.5%). Furthermore, 18.6% of infants <6 months old who had a normal echocardiogram at diagnosis, developed a dilated or aneurysmal coronary artery on a subsequent echocardiogram within 8 weeks of diagnosis. Twenty-eight infants <6 months old received a single dose of infliximab without any untoward effects.
dc.description.abstractConclusions Despite treatment in the first 10 days, infants <6 months old with acute KD are more likely to develop coronary artery abnormalities. Thus, the development of adjunctive therapies to reduce coronary artery damage should target this population.
dc.description.funderNational Heart, Lung, and Blood Institute
dc.description.funderRady Children's Hospital San Diego Physician Development Fund
dc.description.funderNational Center for Research Resources/National Center for Advancing Translational Sciences
dc.description.funderMacklin Foundation
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderNATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jpeds.2017.03.025
dc.identifier.eissn1097-6833
dc.identifier.issn0022-3476
dc.identifier.pubmedidMEDLINE:28408126
dc.identifier.urihttps://doi.org/10.1016/j.jpeds.2017.03.025
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76076
dc.identifier.wosidWOS:000405899400024
dc.information.autorucMedicina;Salgado A;S/I;238036
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherMOSBY-ELSEVIER
dc.revistaJOURNAL OF PEDIATRICS
dc.rightsacceso restringido
dc.subjectPREDICTION
dc.subjectEXTREMES
dc.subjectSPECTRUM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHigh Risk of Coronary Artery Aneurysms in Infants Younger than 6 Months of Age with Kawasaki Disease
dc.typeartículo
dc.volumen185
sipa.codpersvinculados238036
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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