MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort

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dc.contributor.authorGoble, Spencer
dc.contributor.authorAkambase, Joseph
dc.contributor.authorPrieto, Jhon
dc.contributor.authorBalderramo, Domingo
dc.contributor.authorFerrer, Javier Diaz
dc.contributor.authorMattos, Angelo Z.
dc.contributor.authorArrese, Marco
dc.contributor.authorCarrera, Enrique
dc.contributor.authorGroothuismink, Zwier M. A.
dc.contributor.authorOliveira, Jeffrey
dc.contributor.authorBoonstra, Andre
dc.contributor.authorDebes, Jose D.
dc.date.accessioned2025-01-20T17:27:22Z
dc.date.available2025-01-20T17:27:22Z
dc.date.issued2023
dc.description.abstractBackground The rs641738 C > T single-nucleotide polymorphism of MBOAT7 has been associated with hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Latin Americans have high rates of HCC and NAFLD, but no assessment between MBOAT7 and HCC has been performed in this population.Aims We provide the first assessment of the impact of MBOAT7 on HCC risk in Latin Americans.MethodsPatients were prospectively recruited into the ESCALON network, designed to collect samples from Latin American patients with HCC in 6 South American countries (Argentina, Ecuador, Brazil, Chile, Peru, and Colombia). A European cohort and the general Hispanic population of gnomAD database were included for comparison. Associations between HCC and MBOAT7 were evaluated using logistic regression.Results In total, 310 cases of HCC and 493 cases of cirrhosis without HCC were assessed. The MBOAT7 TT genotype was not predictive of HCC in Latin Americans (TT vs CC OR adjusted = 1.15, 95% CI 0.66-2.01, p = 0.610) or Europeans (TT vs CC OR adjusted = 1.20, 95% CI 0.59-2.43, p = 0.621). No significant association was noted on subgroup analysis for NAFLD, viral hepatitis, or alcohol-related liver disease. The TT genotype was increased in the NAFLD-cirrhosis cohort of Latin Americans compared to a non-cirrhotic NAFLD cohort (TT vs CC + CT OR = 2.75, 95% CI 1.10-6.87, p = 0.031).Conclusion The rs631738 C > T allele of MBOAT7 was not associated with increased risk of HCC in Latin Americans or Europeans. An increase in the risk of cirrhosis was noted with the TT genotype in Latin Americans with NAFLD.
dc.description.funderEuropean-Latin American ESCALON consortium, funded by the EU Horizon 2020 program, project number 825510, the Foundation for Liver and Gastrointestinal Research (SLO), AIRP UMN and NIH-R21TW012390-01A1.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10620-023-08104-y
dc.identifier.eissn1573-2568
dc.identifier.issn0163-2116
dc.identifier.urihttps://doi.org/10.1007/s10620-023-08104-y
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91567
dc.identifier.wosidWOS:001064354400002
dc.issue.numero11
dc.language.isoen
dc.pagina.final4220
dc.pagina.inicio4212
dc.revistaDigestive diseases and sciences
dc.rightsacceso restringido
dc.subjectHepatocellular carcinoma
dc.subjectNonalcoholic fatty liver disease
dc.subjectLiver cirrhosis
dc.subjectHispanic or Latino
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort
dc.typeartículo
dc.volumen68
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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