Multifaceted role of synbiotics as nutraceuticals, therapeutics and carrier for drug delivery

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dc.article.number110223
dc.catalogadorpva
dc.contributor.authorKhursheed, R.
dc.contributor.authorGulati, M.
dc.contributor.authorWadhwa, S.
dc.contributor.authorVishwas, S.
dc.contributor.authorSharma, D.S.
dc.contributor.authorCorrie, L.
dc.contributor.authorSingh, S.K.
dc.contributor.authorSteel, A.
dc.contributor.authorAdams, J.
dc.contributor.authorDua, K.
dc.contributor.authorAlam, A.
dc.contributor.authorAlnasser, S.M.
dc.contributor.authorAba, Alkhayl F.F.
dc.contributor.authorParveen, Z.
dc.contributor.authorNammi, S.
dc.contributor.authorChellappan, D.K.
dc.contributor.authorGupta, G.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorJha, N.K.
dc.date.accessioned2023-08-22T21:11:10Z
dc.date.available2023-08-22T21:11:10Z
dc.date.issued2022
dc.description.abstractSynbiotics, are a combination of probiotics and prebiotics. They play an important role in metabolizing different nutritional substrates and thus helps in the maintenance of human health. Any disbalance in the gut microflora, known as dysbiosis, is known to lead to a number of diseased conditions. It can be reverted by the administration of synbiotics. Present review highlights various mechanistic pathways through which synbiotics act as therapeutics. The dual role of synbiotics as nutraceutical and excipient in developing oral formulations are entailed with case studies. The findings entailed that there exist numerous studies on prebiotics as well as probiotics have been carried out to show their effects in several diseases. However, the concept of combining together them for prevention and treatment of various pathological conditions accruing from dysbiosis is relatively new. Synbiotics, however, face challenge of low stability during their sojourn in the GIT, which is generally overcome by various encapsulation techniques. Various studies also showed potential role of synbiotics in drug delivery. However, it is an emerging area and lacks clinical correlation. It is important to focus on clinical trials of formulations wherein synbiotics have been used as therapeutic moiety as well as pharmaceutical carrier for treating various diseases.
dc.description.funderFDA
dc.description.funderWHO
dc.fechaingreso.objetodigital2023-08-22
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.cbi.2022.110223
dc.identifier.eissn1872-27786
dc.identifier.issn0009-2797
dc.identifier.scopusidSCOPUS_ID:85140475172
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2022.110223
dc.identifier.uriwww.elsevier.com/locate/chembioint
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74459
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final29
dc.pagina.inicio1
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofChemico-Biological Interactions
dc.revistaChemico-Biological Interactionses_ES
dc.rightsacceso restringido
dc.subjectColon targeted drug deliveryes_ES
dc.subjectEncapsulationes_ES
dc.subjectGut dysbiosises_ES
dc.subjectSNEDDSes_ES
dc.subjectSynbioticses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleMultifaceted role of synbiotics as nutraceuticals, therapeutics and carrier for drug deliveryes_ES
dc.typeartículo
dc.volumen368
sipa.codpersvinculados1011127
sipa.indexSCOPUS
sipa.trazabilidadSCOPUS;10-11-2022
sipa.trazabilidadORCID;2023-08-21
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