Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats

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dc.contributor.authorRoa, H.
dc.contributor.authorGajardo, C.
dc.contributor.authorTroncoso, E.
dc.contributor.authorFuentealba, V.
dc.contributor.authorEscudero, C.
dc.contributor.authorYanez, A.
dc.contributor.authorSobrevia, L.
dc.contributor.authorPastor Anglada, M.
dc.contributor.authorQuezada, C.
dc.contributor.authorSan Martin, R.
dc.date.accessioned2024-01-10T12:37:25Z
dc.date.available2024-01-10T12:37:25Z
dc.date.issued2009
dc.description.abstractUp regulation of the transforming growth factor-beta 1 (TGF-beta 1) axis has been recognized as a pathogenic event for progression of glomerulosclerosis in diabetic nephropathy. We demonstrate that glomeruli isolated from diabetic rats accumulate up to sixfold more extracellular adenosine than normal rats. Both decreased nucleoside uptake activity by the equilibrative nucleoside transporter 1 and increased AMP hydrolysis contribute to raise extracellular adenosine. Ex vivo assays indicate that activation of the low affinity adenosine A(2B) receptor subtype (A(2B)AR) mediates TGF-beta 1 release from glomeruli of diabetic rats, a pathogenic event that could support progression of glomerulopathy when the bioavailability of adenosine is increased. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
dc.description.funderFONDECYT (Chile)
dc.description.funderUniversidad Austral de Chile (Chile)
dc.description.funderMinisterio de Ciencia e Innovacion (Spain)
dc.description.funderInternational Union of Biochemistry and Molecular Biology (IUBMB)
dc.fechaingreso.objetodigital17-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.febslet.2009.09.003
dc.identifier.issn1873-3468
dc.identifier.pubmedidMEDLINE:19737558
dc.identifier.urihttps://doi.org/10.1016/j.febslet.2009.09.003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76842
dc.identifier.wosidWOS:000271286200015
dc.information.autorucMedicina;Sobrevia L;S/I;1002656
dc.issue.numero19
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final3198
dc.pagina.inicio3192
dc.publisherWILEY
dc.revistaFEBS LETTERS
dc.rightsacceso restringido
dc.subjectAdenosine receptor
dc.subjectTransforming growth factor-beta 1
dc.subjectDiabetic nephropathy
dc.subjectGlomerulus
dc.subjectEQUILIBRATIVE NUCLEOSIDE TRANSPORTER
dc.subjectMESANGIAL CELLS
dc.subjectEXPRESSION LEVEL
dc.subjectTGF-BETA
dc.subjectPROTEIN-KINASE
dc.subjectHIGH GLUCOSE
dc.subjectNEPHROPATHY
dc.subjectRECEPTOR
dc.subjectSTIMULATION
dc.subjectINSULIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAdenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats
dc.typeartículo
dc.volumen583
sipa.codpersvinculados1002656
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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