3D whole-heart grey-blood late gadolinium enhancement cardiovascular magnetic resonance imaging

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dc.contributor.authorMilotta, Giorgia
dc.contributor.authorMunoz, Camila
dc.contributor.authorKunze, Karl P.
dc.contributor.authorNeji, Radhouene
dc.contributor.authorFigliozzi, Stefano
dc.contributor.authorChiribiri, Amedeo
dc.contributor.authorHajhosseiny, R.
dc.contributor.authorMasci, Pier Giorgio
dc.contributor.authorPrieto Vásquez, Claudia
dc.contributor.authorBotnar, René Michael
dc.date.accessioned2021-06-02T13:28:11Z
dc.date.available2021-06-02T13:28:11Z
dc.date.issued2021
dc.date.updated2021-05-30T00:02:31Z
dc.description.abstractAbstract Purpose To develop a free-breathing whole-heart isotropic-resolution 3D late gadolinium enhancement (LGE) sequence with Dixon-encoding, which provides co-registered 3D grey-blood phase-sensitive inversion-recovery (PSIR) and complementary 3D fat volumes in a single scan of < 7 min. Methods A free-breathing 3D PSIR LGE sequence with dual-echo Dixon readout with a variable density Cartesian trajectory with acceleration factor of 3 is proposed. Image navigators are acquired to correct both inversion recovery (IR)-prepared and reference volumes for 2D translational respiratory motion, enabling motion compensated PSIR reconstruction with 100% respiratory scan efficiency. An intermediate PSIR reconstruction is performed between the in-phase echoes to estimate the signal polarity which is subsequently applied to the IR-prepared water volume to generate a water grey-blood PSIR image. The IR-prepared water volume is obtained using a water/fat separation algorithm from the corresponding dual-echo readout. The complementary fat-volume is obtained after water/fat separation of the reference volume. Ten patients (6 with myocardial scar) were scanned with the proposed water/fat grey-blood 3D PSIR LGE sequence at 1.5 T and compared to breath-held grey-blood 2D LGE sequence in terms of contrast ratio (CR), contrast-to-noise ratio (CNR), scar depiction, scar transmurality, scar mass and image quality. Results Comparable CRs (p = 0.98, 0.40 and 0.83) and CNRs (p = 0.29, 0.40 and 0.26) for blood-myocardium, scar-myocardium and scar-blood respectively were obtained with the proposed free-breathing 3D water/fat LGE and 2D clinical LGE scan. Excellent agreement for scar detection, scar transmurality, scar mass (bias = 0.29%) and image quality scores (from 1: non-diagnostic to 4: excellent) of 3.8 ± 0.42 and 3.6 ± 0.69 (p > 0.99) were obtained with the 2D and 3D PSIR LGE approaches with comparable total acquisition time (p = 0.29). Similar agreement in intra and inter-observer variability were obtained for the 2D and 3D acquisition respectively. Conclusion The proposed approach enabled the acquisition of free-breathing motion-compensated isotropic-resolution 3D grey-blood PSIR LGE and fat volumes. The proposed approach showed good agreement with conventional 2D LGE in terms of CR, scar depiction and scan time, while enabling free-breathing acquisition, whole-heart coverage, reformatting in arbitrary views and visualization of both water and fat information.
dc.format.extent14 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2021 May 24;23(1):62
dc.identifier.doi10.1186/s12968-021-00751-2
dc.identifier.urihttps://doi.org/10.1186/s12968-021-00751-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/60462
dc.identifier.wosidWOS:000657740100002
dc.issue.numeroNo. 62
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaJournal of Cardiovascular Magnetic Resonancees_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject3D whole-heartes_ES
dc.subjectRespiratory motion correctiones_ES
dc.subjectLate gadolinium enhancementes_ES
dc.subjectDixon water/fat separationes_ES
dc.subject.ddc616.07548
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.title3D whole-heart grey-blood late gadolinium enhancement cardiovascular magnetic resonance imaginges_ES
dc.typeartículo
dc.volumenVol. 23
sipa.codpersvinculados14195
sipa.codpersvinculados1015313
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