Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity

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dc.catalogadorjlo
dc.contributor.authorSilva, Bryon
dc.contributor.authorTsakani, Edisona
dc.contributor.authorKontopoulos, Alexandros
dc.contributor.authorDe, Joydeep
dc.contributor.authorGaspar, Pedro
dc.contributor.authorHiridjee, Alya
dc.contributor.authorRosselli, Camila
dc.contributor.authorJuan-Sanz, Jaime De
dc.contributor.authorCampusano Astorga, Jorge Mauricio
dc.contributor.authorTreiber, Christoph D.
dc.contributor.authorWaddel, Scott
dc.contributor.authorMiguel-Aliaga, Irene
dc.contributor.authorHadjieconomou, Dafni
dc.date.accessioned2026-01-16T14:10:21Z
dc.date.available2026-01-16T14:10:21Z
dc.date.issued2026
dc.description.abstractAnimals must align intestinal plasticity and feeding with reproductive state, yet the checkpointthat gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axisgates the onset of maternal gut plasticity in Drosophila. Genetic sex establishes endocrinecompetence in a subset of enteric neurons via the sex determination pathway, enabling femalespecific expression of the relaxin-family receptor Lgr3. After mating, steroid signallingincreases Lgr3 receptor expression, priming these neurons for reproductive adaptation. Onceoocytes mature fully, follicle cells secrete the relaxin-like hormone dILP8, which activatesLgr3 to trigger gut enlargement and increased feeding. Disrupting the sex determinationpathway in enteric neurons, Lgr3, or ovarian dILP8 prevents gut enlargement and reducesfeeding. Thus, genetic sex establishes competence, steroid signalling primes it, and ovarianrelaxin triggers it, defining a maternal intestinal plasticity checkpoint that ensures gutadaptations initiate only once reproduction is underway and energy demands peak. Ourfindings delineate an ovary-to-enteric-neuron axis that couples reproductive state to maternalgut plasticity.
dc.fechaingreso.objetodigital2025-01-16
dc.format.extent41 páginas
dc.fuente.origenORCID
dc.identifier.doi10.64898/2026.01.09.698651
dc.identifier.urihttps://doi.org/10.64898/2026.01.09.698651
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107723
dc.information.autorucFacultad de Ciencias Biológicas; Campusano Astorga, Jorge Mauricio; 0000-0001-5254-8340; 3965
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistabioRxiv
dc.rightscontenido completo
dc.subject.ddc570
dc.titleGenetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity
dc.typepreprint
sipa.codpersvinculados3965
sipa.trazabilidadORCID;2026-01-12
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