Development of a photosynthetic hydrogel as potential wound dressing for the local delivery of oxygen and bioactive molecules.

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dc.catalogadorjca
dc.contributor.authorCorrales-Orovio, Rocío
dc.contributor.authorCarvajal, Felipe
dc.contributor.authorHolmes, Christopher
dc.contributor.authorMiranda, Miguel
dc.contributor.authorGonzález-Itier, Sergio
dc.contributor.authorCárdenas, Camila
dc.contributor.authorVera, Constanza
dc.contributor.authorSchenck, Thilo
dc.contributor.authorEgaña, José Tomás
dc.date.accessioned2024-02-27T16:02:45Z
dc.date.available2024-02-27T16:02:45Z
dc.date.issued2022
dc.description.abstractThe development of biomaterials to improve wound healing is a critical clinical challenge and an active field of research. As it is well described that oxygen plays a critical role in almost each step of the wound healing process, in this work, an oxygen producing photosynthetic biomaterial was generated, characterized, and further modified to additionally release other bioactive molecules. Here, alginate hydrogels were loaded with the photosynthetic microalgae Chlamydomonas reinhardtii, showing high integration as well as immediate oxygen release upon illumination. Moreover, the photosynthetic hydrogel showed high biocompatibility in vitro and in vivo, and the capacity to sustain the metabolic oxygen requirements of zebrafish larvae and skin explants. In addition, the photosynthetic dressings were evaluated in 20 healthy human volunteers following the ISO-10993-10-2010 showing no skin irritation, mechanical stability of the dressings, and survival of the photosynthetic microalgae. Finally, hydrogels were also loaded with genetically engineered microalgae to release human VEGF, or pre-loaded with antibiotics, showing sustained release of both bioactive molecules. Overall, this work shows that photosynthetic hydrogels represent a feasible approach for the local delivery of oxygen and other bioactive molecules to promote wound healing.
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.actbio.2022.11.036
dc.identifier.issn1742-7061
dc.identifier.urihttps://doi.org/10.1016/j.actbio.2022.11.036
dc.identifier.urihttp://europepmc.org/abstract/med/36435443
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81331
dc.information.autorucFacultad de Ciencias Biológicas;Carvajal, Felipe;S/I;171996
dc.information.autorucFacultad de Ciencias Biológicas;Holmes, Christopher;S/I;187014
dc.information.autorucEscuela de Ingeniería;González Itier, Sergio;S/I;1070568
dc.information.autorucFacultad de Ciencias Biológicas;Cárdenas, Camila;S/I;195529
dc.information.autorucFacultad de Ciencias Biológicas;Vera, Constanza;SI;195533
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Egaña Erazo, Jose Tomas; 0000-0003-2624-6992; 1018715
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final166
dc.pagina.inicio154
dc.revistaActa Biomaterialia
dc.rightsacceso restringido
dc.subjectWound dressing
dc.subjectPhotosynthetic hydrogel
dc.subjectOxygen delivery
dc.subjectMicroalgae
dc.subjectDrug release
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleDevelopment of a photosynthetic hydrogel as potential wound dressing for the local delivery of oxygen and bioactive molecules.
dc.typeartículo
dc.volumen155
sipa.codpersvinculados171996
sipa.codpersvinculados187014
sipa.codpersvinculados1070568
sipa.codpersvinculados195529
sipa.codpersvinculados195533
sipa.codpersvinculados1018715
sipa.trazabilidadORCID;2024-01-15
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