Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternativesEstrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas

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dc.contributor.authorMiranda H R.
dc.contributor.authorCastro G P.
dc.contributor.authorVerdejo P H.
dc.contributor.authorChiong M.
dc.contributor.authorDíaz-Araya G.
dc.contributor.authorMellado R.
dc.contributor.authorRojas D.
dc.contributor.authorLavandero S.
dc.contributor.authorConcepción R.
dc.contributor.authorCastro G P.
dc.contributor.authorLavandero S.
dc.date.accessioned2024-01-10T14:23:48Z
dc.date.available2024-01-10T14:23:48Z
dc.date.issued2007
dc.description.abstractDespite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a higher generation of reactive oxygen species. This phenomenon, along with pro-inflammatory cytokine activation and extra cellular matrix alterations with reactive fibrosis, play an important role in the pathogenesis and progression of heart failure, through the development of endothelial and myocardial dysfunction. The understanding of the underlying phenomena and the metabolic pathways involved will allow further development of therapies aiming to change the natural history of heart failure.
dc.fechaingreso.objetodigital2024-05-14
dc.fuente.origenScopus
dc.identifier.eissn07176163
dc.identifier.issn00349887 07176163
dc.identifier.pubmedid17989865
dc.identifier.scopusidSCOPUS_ID:36248987146
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80144
dc.information.autorucFacultad de Medicina; Verdejo Pinochet, Hugo Eduardo; S/I; 1001175
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1063
dc.pagina.inicio1056
dc.revistaRevista Medica de Chile
dc.rightsregistro bibliográfico
dc.subjectEndothelial cells
dc.subjectHeart failure, congestive
dc.subjectOxidative stress
dc.titleOxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternativesEstrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas
dc.typeartículo de revisión
dc.volumen135
sipa.codpersvinculados1001175
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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