Diversity matters: opportunities in the study of the genetics of psychotic disorders in low- and middle-income countries in Latin America

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dc.catalogadorgjm
dc.contributor.authorFonseca, Lais
dc.contributor.authorSena, Brena F.
dc.contributor.authorCrossley, Nicolás
dc.contributor.authorLopez Jaramillo, Carlos
dc.contributor.authorKoenen, Karestan
dc.contributor.authorFreimer, Nelson B.
dc.contributor.authorBressan, Rodrigo A.
dc.contributor.authorBelangero, Sintia I.
dc.contributor.authorSantoro, Marcos L.
dc.contributor.authorGadelha, Ary
dc.date.accessioned2024-06-06T20:10:58Z
dc.date.available2024-06-06T20:10:58Z
dc.date.issued2021
dc.description.abstractLack of diversity regarding genetic and environmental backgrounds weakens the generalization and clinical applicability of research findings on psychotic disorders. Notably, Latin Americans have been generally neglected in genetic studies, comprising less than 2% of genome-wide association study samples. But Latin American populations represent a unique opportunity for research, given the exceptionally high ethnic admixture of this group. Increasing genetic diversity is essential to improve the fine mapping of known regions associated with psychotic disorders, discover novel genetic associations, and replicate studies. Additionally, Latin America is characterized by massive social, political, and economic inequalities, all known risk factors for mental health issues, including psychotic disorders. This article aims to 1) discuss the challenges and advantages of studying Latin America's particular genetic makeup and environmental context; 2) review previous studies conducted in the region; and 3) describe three Latin American research initiatives in progress: the Neuropsychiatric Genetics of Psychosis in Mexican Populations (NeuroMEX), the Paisa, and the Latin American Network for the Study of Early Psychosis (ANDES) studies.
dc.description.funderCoordenacao de Aperfeicoamento Pessoal de Nivel Superior (CAPES)
dc.description.funderConselho Nacional de Desenvolvimento Cienti'fico e Tecnologico (CNPq)
dc.description.funderFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.fechaingreso.objetodigital2024-06-06
dc.fuente.origenORCID
dc.identifier.doi10.1590/1516-4446-2020-1240
dc.identifier.eissn1809-452X
dc.identifier.issn1516-4446
dc.identifier.pubmedidMEDLINE:33237255
dc.identifier.urihttps://doi.org/10.1590/1516-4446-2020-1240
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86597
dc.identifier.wosidWOS:000760090300014
dc.information.autorucEscuela de Medicina; Crossley, Nicolás; 0000-0002-3060-656X; 11224
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final637
dc.pagina.inicio631
dc.revistaBrazilian Journal of Psychiatry
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC 4.0 ATTRIBUTION-NONCOMMERCIAL 4.0 INTERNATIONAL Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectLatin America
dc.subjectPsychotic disorders
dc.subjectSchizophrenia
dc.subjectGenetics
dc.subjectEnvironment
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDiversity matters: opportunities in the study of the genetics of psychotic disorders in low- and middle-income countries in Latin America
dc.typeartículo
dc.volumen43
sipa.codpersvinculados11224
sipa.trazabilidadORCID;2024-06-03
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