Endothelial dysfunction - A link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events?

Simple item page
dc.contributor.authorGermain, Alfredo M.
dc.contributor.authorRomanik, Mary Carmen
dc.contributor.authorGuerra, Irene
dc.contributor.authorSolari, Sandra
dc.contributor.authorSoledad Reyes, Maria
dc.contributor.authorJohnson, Richard J.
dc.contributor.authorPrice, Karen
dc.contributor.authorKarumanchi, S. Ananth
dc.contributor.authorValdes, Gloria
dc.date.accessioned2024-01-10T13:48:01Z
dc.date.available2024-01-10T13:48:01Z
dc.date.issued2007
dc.description.abstractWe tested the hypothesis that endothelial dysfunction could cause placentation-related defects, persist after the complicated pregnancy, and probably cause cardiovascular disease later in life. Brachial arterial reactivity and factors related to endothelial dysfunction, such as circulating cholesterol, uric acid, nitrites, L-arginine, asymmetrical dimethylarginine, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptor-1, in women with previous healthy pregnancies (n = 22), patients with severe preeclampsia (n = 25), or patients with recurrent pregnancy loss (n = 29), at day 10 of the luteal phase of an ovulatory cycle an average of 11 to 27 months after pregnancy were evaluated. Both groups with placentation defects had a significant decrease in endothelium-dependent dilatation, a higher rate of endothelial dysfunction, lower serum nitrites, and higher cholesterol as compared with control subjects; subjects with previous preeclampsia additionally had higher normal blood pressures and a greater parental prevalence of cardiovascular disease. Patients with recurrent pregnancy loss also demonstrated a significantly lower endothelium-independent vasodilatation. A trend to an inverse correlation was found between serum cholesterol serum and endothelial-mediated vasodilatation in the whole study population. Uric acid, L-arginine, asymmetrical dimethylarginine, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptor-1 were similar in all of the groups. We postulate that endothelial dysfunction may represent a link between preeclampsia and increased cardiovascular disease latter in life and propose that women with unexplained recurrent miscarriages are also at increased cardiovascular risk. The identification and correction of endothelial dysfunction detected during the reproductive stage on obstetric outcome and on cardiovascular diseases needs to be elucidated.
dc.fechaingreso.objetodigital2024-05-06
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/01.HYP.0000251522.18094.d4
dc.identifier.eissn1524-4563
dc.identifier.issn0194-911X
dc.identifier.pubmedidMEDLINE:17116761
dc.identifier.urihttps://doi.org/10.1161/01.HYP.0000251522.18094.d4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79326
dc.identifier.wosidWOS:000243598500021
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final95
dc.pagina.inicio90
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaHYPERTENSION
dc.rightsregistro bibliográfico
dc.subjectendothelial dysfunction
dc.subjectendothelium-mediated vasodilatation
dc.subjectpregnancy
dc.subjectpreeclampsia
dc.subjectrecurrent abortion
dc.subjectcardiovascular risk
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectASYMMETRIC DIMETHYLARGININE
dc.subjectRETROSPECTIVE COHORT
dc.subjectBIOLOGICAL SAMPLES
dc.subjectFAMILY-HISTORY
dc.subjectHEART-DISEASE
dc.subjectL-ARGININE
dc.subjectRISK
dc.subjectHYPERTENSION
dc.subjectWOMEN
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleEndothelial dysfunction - A link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events?
dc.typeartículo
dc.volumen49
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Endothelial Dysfunction.pdf
Size:
98.14 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas