Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment

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dc.catalogadorpau
dc.contributor.authorAngel Carvajal-Oliveros
dc.contributor.authorEfthimios M. C. Skoulakis
dc.contributor.authorCarmen Dominguez-Baleón
dc.contributor.authorIván Sánchez-Díaz
dc.contributor.authorDiego Zambrano-Tipan
dc.contributor.authorRené Hernández-Vargas
dc.contributor.authorCampusano Astorga, Jorge Mauricio
dc.contributor.authorVerónica Narváez-Padilla
dc.contributor.authorEnrique Reynaud
dc.date.accessioned2024-03-08T19:00:12Z
dc.date.available2024-03-08T19:00:12Z
dc.date.issued2023
dc.description.abstractSynphilin-1 is a protein encoded by the human SNCAIP gene whose function has yet to be fully understood. However, it has been linked to familial Parkinson’s disease (PD). Synphilin-1 is a major component of the Lewy bodies found in neurons in the substantia nigra pars compacta of PD patients. Synphilin-1 expression in serotonergic and/or dopaminergic neurons of Drosophila melanogaster induces neurodegeneration, as well as motor and non-motor PD like symptoms. In this work, we examined the contribution of the serotonergic and dopaminergic circuits in the development of PD-like phenotypes. We found that olfactory and visual symptoms are majorly contributed by the serotonergic system, and that motor symptoms and reduction in survival are mainly contributed by the dopaminergic system. Chronic nicotine treatment was able to suppress several of these symptoms. These results indicate that both the serotonergic and dopaminergic systems contribute to different aspects of PD symptomatology and that nicotine has beneficial effects on specific symptoms.
dc.fechaingreso.objetodigital2024-11-21
dc.format.extent16 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1371/journal.pone.0282348
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0282348
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84317
dc.identifier.wosidWOS:000942456500014
dc.information.autorucFacultad de Ciencias Biológicas; Campusano Astorga, Jorge Mauricio; 0000-0001-5254-8340; 3965
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaPLoS ONE
dc.rightsacceso abierto
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleParkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment
dc.typepreprint
dc.volumen18
sipa.codpersvinculados3965
sipa.trazabilidadORCID;2024-01-15
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