Maternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate

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dc.contributor.authorMazaki Tovi, Shali
dc.contributor.authorVaisbuch, Edi
dc.contributor.authorRomero, Roberto
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorKim, Sun Kwon
dc.contributor.authorNhan Chang, Chia Ling
dc.contributor.authorGomez, Ricardo
dc.contributor.authorSavasan, Zeynep Alpay
dc.contributor.authorMadan, Ichchha
dc.contributor.authorYoon, Bo Hyun
dc.contributor.authorYeo, Lami
dc.contributor.authorMittal, Pooja
dc.contributor.authorOgge, Giovanna
dc.contributor.authorGonzalez, Juan M.
dc.contributor.authorHassan, Sonia S.
dc.date.accessioned2024-01-10T13:50:18Z
dc.date.available2024-01-10T13:50:18Z
dc.date.issued2010
dc.description.abstractObjective. Maternal circulating visfatin concentrations are higher in patients with a small-for-gestational-age (SGA) neonate than in those who delivered an appropriate-for-gestational age (AGA) neonate or in those with pre-eclampsia. It has been proposed that enhanced transfer of visfatin from the foetal to maternal circulation may account for the high concentrations of maternal visfatin observed in patients with an SGA neonate. The aims of this study were: (1) to determine whether cord blood visfatin concentrations differ between normal neonates, SGA neonates and newborns of pre-eclamptic mothers; and (2) to assess the relationship between maternal and foetal circulating visfatin concentrations in patients with an SGA neonate and those with pre-eclampsia.
dc.description.abstractStudy design. This cross-sectional study included 88 pregnant women and their neonates, as well as 22 preterm neonates in the following groups: (1) 44 normal pregnant women at term and their AGA neonates; (2) 22 normotensive pregnant women and their SGA neonates; (3) 22 women with pre-eclampsia and their neonates; and (4) 22 preterm neonates delivered following spontaneous preterm labour without funisitis or histologic chorioamnionitis, matched for gestational age with infants of pre-eclamptic mothers. Maternal plasma and cord blood visfatin concentrations were determined by ELISA. Nonparametric statistics were used for analyses.
dc.description.abstractResults. (1) The median visfatin concentration was lower in umbilical cord blood than in maternal circulation, in normal pregnancy, SGA and pre-eclampsia groups (p<0.001 for all comparisons); (2) the median cord blood visfatin concentrations did not differ significantly between term AGA or SGA neonates, infants of mothers with pre-eclampsia and their gestational-age-matched preterm AGA neonates; (3) maternal and cord blood visfatin concentrations correlated only in the normal term group (r=0.48, p=0.04).
dc.description.abstractConclusion. Circulating visfatin concentrations are lower in the foetal than in the maternal circulation and did not significantly differ between the study groups. Thus, it is unlikely that the foetal circulation is the source of the high maternal visfatin concentrations reported in patients with an SGA neonate.
dc.description.funderPerinatology Research Branch, Division of Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS
dc.fechaingreso.objetodigital2024-05-13
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/14767050903572190
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmedidMEDLINE:20121389
dc.identifier.urihttps://doi.org/10.3109/14767050903572190
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79521
dc.identifier.wosidWOS:000282081100007
dc.information.autorucMedicina;Gomez R ;S/I;80926
dc.issue.numero10
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final1128
dc.pagina.inicio1119
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsregistro bibliográfico
dc.subjectVisfatin
dc.subjectadipokines
dc.subjectcytokine
dc.subjectpregnancy
dc.subjectfoetal growth restriction
dc.subjectappropriate-for-gestational age
dc.subjectumbilical cord blood
dc.subjectCOLONY-ENHANCING FACTOR
dc.subjectSERUM ADIPONECTIN MULTIMERS
dc.subjectFACTOR RECEPTOR-1 CONCENTRATION
dc.subjectFETAL MEMBRANE DISTENSION
dc.subjectPLACENTAL GROWTH-FACTOR
dc.subjectNORMAL-PREGNANCY
dc.subjectSOLUBLE ENDOGLIN
dc.subjectINSULIN-RESISTANCE
dc.subjectANGIOGENIC FACTORS
dc.subjectDIABETES-MELLITUS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMaternal and neonatal circulating visfatin concentrations in patients with pre-eclampsia and a small-for-gestational age neonate
dc.typeartículo
dc.volumen23
sipa.codpersvinculados80926
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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