Normal plasma insulin and HOMA values among chilean children and adolescents

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dc.contributor.authorBarja, Salesa
dc.contributor.authorArnaiz, Pilar
dc.contributor.authorDominguez, Angelica
dc.contributor.authorVillarroel, Luis
dc.contributor.authorCassis, Berta
dc.contributor.authorCastillo, Oscar
dc.contributor.authorSalomo, Gianina
dc.contributor.authorFarias, Marcelo
dc.contributor.authorGoycoolea, Manuela
dc.contributor.authorQuiroga, Teresa
dc.contributor.authorMardones, Francisco
dc.date.accessioned2024-01-10T14:22:35Z
dc.date.available2024-01-10T14:22:35Z
dc.date.issued2011
dc.description.abstractBackground: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. Aim: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years, according to sex and puberal maturation. Material and Methods: A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropoinetry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. Results: The reference group included only subjects with normal body mass index and fasting blood glucose (n = 1,192). Girls had higher insulin and HOMA values than boys (12.5 +/- 6.0 and 9.1 +/- 4.9 mu U/mL (p <0.01) and 2.7 +/- 1.4 and 2.1 +/- 1,1 (p <0.01), respectively). Subjects with Tanner land II puberal stages had lower insulin and HOMA mean values than subjects with Tanner III and IV (9.0 +/- 4.3 and 12.5 +/- 6.2 mu U/ml (p < 0.01) and 2.0 +/- 1 and 2.8 +/- 1.4 (p <0.01), respectively). Conclusions: The 90th percentile of insulin and HOMA distributions according to sex and maturation, was selected as the upper cut-off point to identify individuals with insulin resistance. HOMA cutoff point for Tanner I and II boys was 3.2, for Tanner land II girls was 4.1, for Tanner III and IV boys was 4.2 and for Tanner III and IV girls was 5.0. (Rev Med Chile 2011; 139: 1435-1443).
dc.fechaingreso.objetodigital2024-05-13
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872011001100007
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:22446648
dc.identifier.urihttps://doi.org/10.4067/S0034-98872011001100007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79964
dc.identifier.wosidWOS:000298576100007
dc.information.autorucFacultad de Medicina; Farias Jofre, Marcelo Enrique; S/I; 12286
dc.issue.numero11
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1443
dc.pagina.inicio1435
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectAdolescent
dc.subjectChild
dc.subjectInsulin resistance
dc.subjectHOMEOSTASIS MODEL ASSESSMENT
dc.subjectCARDIOVASCULAR RISK-FACTORS
dc.subjectTYPE-2 DIABETES-MELLITUS
dc.subjectBETA-CELL FUNCTION
dc.subjectMETABOLIC SYNDROME
dc.subjectGLUCOSE-TOLERANCE
dc.subjectOBESE CHILDREN
dc.subjectBODY-FAT
dc.subjectRESISTANCE
dc.subjectSENSITIVITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNormal plasma insulin and HOMA values among chilean children and adolescents
dc.typeartículo
dc.volumen139
sipa.codpersvinculados12286
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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