Intra-individual response variability assessed by ex-Gaussian analysis may be a new endophenotype for attention-deficit/hyperactivity disorder

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dc.contributor.authorHenriquez-Henriquez, M. P.
dc.contributor.authorBilleke, P.
dc.contributor.authorHenriquez, H.
dc.contributor.authorZamorano, F. J.
dc.contributor.authorRothhammer, F.
dc.contributor.authorAboitiz, Francisco
dc.date.accessioned2020-01-14T01:43:03Z
dc.date.available2020-01-14T01:43:03Z
dc.date.issued2015
dc.description.abstractIntra-individual variability of response times (RTisv) is considered as potential endophenotype for attentional deficit/hyperactivity disorder (ADHD). Traditional methods for estimating RTisv lose information regarding response times (RTs) distribution along the task, with eventual effects on statistical power. Ex-Gaussian analysis captures the dynamic nature of RTisv, estimating normal and exponential components for RT distribution, with specific phenomenological correlates. Here, we applied ex-Gaussian analysis to explore whether intra-individual variability of RTs agrees with criteria proposed by Gottesman and Gould for endophenotypes. Specifically, we evaluated if normal and/or exponential components of RTs may (a) present the stair-like distribution expected for endophenotypes (ADHD > siblings > typically developing children (TD) without familiar history of ADHD) and (b) represent a phenotypic correlate for previously described genetic risk variants. This is a pilot study including 55 subjects (20 ADHD-discordant sibling-pairs and 15 TD children), all aged between 8 and 13 years. Participants resolved a visual Go/Nogo with 10% Nogo probability. Ex-Gaussian distributions were fitted to individual RT data and compared among the three samples. In order to test whether intra-individual variability may represent a correlate for previously described genetic risk variants, VNTRs at DRD4 and SLC6A3 were identified in all sibling-pairs following standard protocols. Groups were compared adjusting independent general linear models for the exponential and normal components from the ex-Gaussian analysis. Identified trends were confirmed by the non-parametric Jonckheere–Terpstra test. Stair-like distributions were observed for μ (p = 0.036) and σ (p = 0.009). An additional “DRD4-genotype” × “clinical status” interaction was present for τ (p = 0.014) reflecting a possible severity factor. Thus, normal and exponential RTisv components are suitable as ADHD endophenotypes.
dc.format.extent1 página
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.3389/fpsyt.2014.00197
dc.identifier.issn1664-0640
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27507
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.inicio8
dc.revistaFrontiers in Psychiatryes_ES
dc.rightsacceso abierto
dc.subjectEx-Gaussian analysises_ES
dc.subjectADHDes_ES
dc.subjectIntra-individual variabilityes_ES
dc.subjectEndophenotypeses_ES
dc.subjectResponse timees_ES
dc.subjectDeficit-hyperactivity-disorderes_ES
dc.subjecteaction-time variabilityes_ES
dc.subjectIntraindividual variabilityes_ES
dc.subjectDrd4 genees_ES
dc.subjectSustained attentiones_ES
dc.subjectAdhdes_ES
dc.subjectSymptomses_ES
dc.subjectChildrenes_ES
dc.subjectPerformancees_ES
dc.subjectVariantses_ES
dc.subjectDat1es_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleIntra-individual response variability assessed by ex-Gaussian analysis may be a new endophenotype for attention-deficit/hyperactivity disorderes_ES
dc.typeartículo
dc.volumenVol. 5
sipa.codpersvinculados12299
sipa.codpersvinculados100165
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