Publicaciones académicas

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Esta colección incluye artículos de profesores de la Pontificia Universidad Católica de Chile, publicados en revistas nacionales y extranjeras.

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Now showing 1 - 20 of 4115

1,4-Dihydropyridines: Reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation
(2004) Valenzuela, V.; Santander, P.; Camargo, C.; Squella, J.A.; López Alarcón, Camilo Ignacio; Nuñez Vergara, L.J.
1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole derivatives: A novel approach to the development of new HIV-1 reverse transcriptase inhibitors
(2007) Vásquez Velásquez, David; Lagos Arévalo, Carlos Fernando; Mella Raipán, Jaime Alberto; González Contreras, Luis Gerardo; Ebensperger González, Roberto Alejandro; Alvarez Figueroa, María Javiera; Sáez Moya, Edmundo Alfredo; Pessoa Mahana, Hernán; Araya Secchi, Raul; Gonzalez Wong, Angel; Perez-Acle, Tomas; Pessoa Mahana, Carlos David
10-year experience in patients operated for acute invasive fungal rhinosinusitis
(2020) Lagos, A.; Ferrada, S.; Muñoz, T.; Maul Fonseca, Ximena; Finkelstein, A.; González, C.; Fonseca Arrieta, María Ximena; Callejas Canepa, Claudio Andrés
11 beta-Hydroxysteroid Dehydrogenase Type 1 is Overexpressed in Subcutaneous Adipose Tissue of Morbidly Obese Patients
(SPRINGER, 2009) Munoz, Rodrigo; Carvajal, Cristian; Escalona, Alex; Boza, Camilo; Perez, Gustavo; Ibanez, Luis; Fardella, Carlos
11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) enzyme catalyzes interconversion of inactive cortisone to active cortisol. Its expression in adipose tissue has been associated with obesity and some of its metabolic disorders. Controversies regarding which fat depots [subcutaneous adipose tissue (SAT) or visceral adipose tissue (VAT)] have higher expression still remain. The aim of this work was to evaluate 11 beta-HSD1 expression in SAT and VAT of obese patients and evaluate its association to metabolic features of metabolic syndrome.
11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension
(HUMANA PRESS INC, 2010) Campino, Carmen; Carvajal, Cristian A.; Cornejo, Javiera; San Martin, Betty; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Sateler, Javiera; Baudrand, Rene; Mosso, Lorena; Owen, Gareth I.; Kalergis, Alexis M.; Padilla, Oslando; Fardella, Carlos E.
Cortisol availability is modulated by several enzymes: 11 beta-HSD2, which transforms cortisol (F) to cortisone (E) and 11 beta-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5 alpha- and 5 beta-reductase) inactivate cortisol (together with 3 alpha-HSD) to tetrahydrometabolites: 5 alpha THF, 5 beta THF, and THE. The aim was to assess 11 beta-HSD2, 11 beta-HSD1, and 5 beta-reductase activity in hypertensive patients. Free urinary F, E, THF, and THE were measured by HPLC-MS/MS in 102 essential hypertensive patients and 18 normotensive controls. 11 beta-HSD2 enzyme activity was estimated by the F/E ratio, the activity of 11 beta-HSD1 in compare to 11 beta-HSD2 was inferred by the (5 alpha THF + 5 beta THF)/THE ratio and 5 beta-reductase activity assessed using the E/THE ratio. Activity was considered altered when respective ratios exceeded the maximum value observed in the normotensive controls. A 15.7% of patients presented high F/E ratio suggesting a deficit of 11 beta-HSD2 activity. Of the remaining 86 hypertensive patients, two possessed high (5 alpha THF + 5 beta THF)/THE ratios and 12.8% had high E/THE ratios. We observed a high percentage of alterations in cortisol metabolism at pre-receptor level in hypertensive patients, previously misclassified as essential. 11 beta-HSD2 and 5 beta-reductase decreased activity and imbalance of 11 beta-HSDs should be considered in the future management of hypertensive patients.
(13)C NMR studies of heterocyclic naphtho- and anthraquinones. Deshielding effect on the carbonyl carbon with methyl substitution
(2008) Salas Sánchez, Cristián Osvaldo; Armstrong Lattapiat, Ana Verónica; López Astorga, Claudio; Tapia Apati, Ricardo
14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial
(ELSEVIER SCIENCE INC, 2011) Greenberg, E. Robert; Anderson, Garnet L.; Morgan, Douglas R.; Torres, Javier; Chey, William D.; Eduardo Bravo, Luis; Dominguez, Ricardo L.; Ferreccio, Catterina; Herrero, Rolando; Lazcano Ponce, Eduardo C.; Mercedes Meza Montenegro, Maria; Pena, Rodolfo; Pena, Edgar M.; Salazar Martinez, Eduardo; Correa, Pelayo; Elena Martinez, Maria; Valdivieso, Manuel; Goodman, Gary E.; Crowley, John J.; Baker, Laurence H.
Background Evidence from Europe, Asia, and North America suggests that standard three-drug regimens of a proton-pump inhibitor plus amoxicillin and clarithromycin are significantly less effective for eradication of Helicobacter pylori infection than are 5-day concomitant and 10-day sequential four-drug regimens that include a nitroimidazole. These four-drug regimens also entail fewer antibiotic doses than do three-drug regimens and thus could be suitable for eradication programmes in low-resource settings. Few studies in Latin America have been done, where the burden of H pylori-associated diseases is high. We therefore did a randomised trial in Latin America comparing the effectiveness of four-drug regimens given concomitantly or sequentially with that of a standard 14-day regimen of triple therapy.
2 Golden rats and sick empires: portraying medicine, poverty, and the bubonic plague in La Peste
(Manchester University Press, 2022) Ragas Rojas, José Frank; Palma Maturana, Patricia Nataly; González Donoso, Guillermo Adrián
With a ten-million-euro budget and 400 extras on set, La Peste (The Plague) – a ten-episode TV show produced by Spanish communication conglomerate Movistar and aired in January 2018 – became not only the most ambitious production in Spanish television history but also an overnight sensation among viewers and critics. This chapter examines how La Peste combines historical accuracy and fiction to portray the role of medicine, health agents, and population around a late sixteenth-century epidemic outbreak. Its release coincided with the centennial of the Spanish flu that killed twenty to fifty million people around the globe. In placing the epidemic at the core of the narrative, the show unveils the multiple yet contradictory ways people from various social groups and backgrounds reacted to the pandemic: either to save their own lives, procure a cure for others, or to take advantage of the crisis. The chapter highlights what makes La Peste a relevant case to study. As part of its marketing campaign, the production team deliberately sought to trespass the screen and insert the narrative into people’s daily lives. This team designed in advance of the TV series an interactive website with digital resources on the history of medicine and historical sites. Furthermore, in the days prior to the launch, several golden rats appeared in the streets of Seville to announce the show. While some viewers expressed their discomfort with the crude scenes depicting poor living conditions, others engaged with the campaign. As a result of this, La Peste constitutes a fascinating example of the possibilities offered by TV shows as vehicles for disseminating historical medical knowledge to a vast audience.
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors
(2010) Luhr, Susan; Vilches-Herrera, Marcelo; Fierro Huerta, Angélica; Ramsay, Rona R.; Edmondson, Dale E.; Reyes-Parada, Miguel; Cassels, Bruce K.; Iturriaga-Vasquez, Patricio
2D Autocorrelation modeling of the activity of trihalobenzocycloheptapyridine analogues as farnesyl protein transferase inhibitors
(2005) Fernandez, M.; Tundidor Camba, Alain; Caballero, J.
3,5-Dimethyl-1-(4-nitrophenyl)-4-[(E)-(2,3,4,5,6-pentafluorophenyl) diazenyl]-1H-pyrazole
(2007) Bustos, Carlos; Sánchez Villalón, Christián Orlando; Schott Verdugo, Eduardo Enrique; Alvarez-Thon, Luis; Fuentealba, Mauricio
3D free-breathing cardiac magnetic resonance fingerprinting
(2020) Cruz, G.; Jaubert, O.; Qi, H. K.; Bustin, A.; Milotta, G.; Schneider, T.; Koken, P.; Doneva, M.; Botnar, René Michael; Prieto Vásquez, Claudia
3D MR coronary artery segmentation
(LIPPINCOTT WILLIAMS & WILKINS, 1998) Cline, HE; Thedens, DR; Irarrazaval, P; Meyer, CH; Hu, BS; Nishimura, DG; Ludke, S
Coronary arteries are segmented from the blood pool using mathematical morphology operations from a 3D magnetic resonance spiral acquisition on a continuously breathing healthy volunteer. The segmented volume is maximal intensity projected at different views to yield coronary angiograms showing the left anterior descending artery (LAD), right coronary artery (RCA), and left circumflex artery (LCX), Magnetic resonance coronary angiography provides a retrospective rotating view of the coronary artery tree that complements oblique reformatted sections.
3D Undersampled Golden-Radial Phase Encoding for DCE-MRA Using Inherently Regularized Iterative SENSE
(2010) Prieto, Claudia; Uribe Arancibia, Sergio A.; Razavi, Reza; Atkinson, David; Schaeffter, Tobias
3D whole-heart free-breathing qBOOST-T2 mapping
(2020) Milotta, G.; Ginami, G.; Bustin, A.; Neji, R.; Prieto Vásquez, Claudia; Botnar, René Michael
3D whole-heart isotropic-resolution motion-compensated joint T-1/T(2)mapping and water/fat imaging
(2020) Milotta, Giorgia; Bustin, Aurelien; Jaubert, Olivier; Neji, Radhouene; Prieto Vásquez, Claudia; Botnar, René Michael
Purpose To develop a free-breathing isotropic-resolution whole-heart joint T1 and T2 mapping sequence with Dixon-encoding that provides coregistered 3D T1 and T2 maps and complementary 3D anatomical water and fat images in a single ~9 min scan. Methods Four interleaved dual-echo Dixon gradient echo volumes are acquired with a variable density Cartesian trajectory and different preparation pulses: 1) inversion recovery-preparation, 2) and 3) no preparations, and 4) T2 preparation. Image navigators are acquired to correct each echo for 2D translational respiratory motion; the 8 echoes are jointly reconstructed with a low-rank patch-based reconstruction. A water/fat separation algorithm is used to obtain water and fat images for each acquired volume. T1 and T2 maps are generated by matching the signal evolution of the water images to a simulated dictionary. Complementary bright-blood and fat volumes for anatomical visualization are obtained from the T2-prepared dataset. The proposed sequence was tested in phantom experiments and 10 healthy subjects and compared to standard 2D MOLLI T1 mapping, 2D balance steady-state free precession T2 mapping, and 3D T2-prepared Dixon coronary MR angiography. Results High linear correlation was found between T1 and T2 quantification with the proposed approach and phantom spin echo measurements (y = 1.1 × −11.68, R2 = 0.98; and y = 0.85 × +5.7, R2 = 0.99). Mean myocardial values of T1/T2 = 1116 ± 30.5 ms/45.1 ± 2.38 ms were measured in vivo. Biases of T1/T2 = 101.8 ms/−0.77 ms were obtained compared to standard 2D techniques. Conclusion The proposed joint T1/T2 sequence permitted the acquisition of motion-compensated isotropic-resolution 3D T1 and T2 maps and complementary coronary MR angiography and fat volumes, showing promising results in terms of T1 and T2 quantification and visualization of cardiac anatomy and pericardial fat.
4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo
(2012) Sotomayor Zárate, Ramón Eduardo; Quiroz, Gabriel; Araya Gutiérrez, Katherine Angélica; Abarca, Jorge; Ibañez, Maria R.; Montecinos, Alejandro; Guajardo, Carlos; Nuñez, Gabriel; Fierro Huerta, Angélica; Moya, Pablo R.; Iturriaga-Vasquez, Patricio; Gomez-Molina, Cristobal; Gysling Caselli, Katia
4-{3,5-Dimethyl-4-[(E)-(4-methylphenyl)diazenyl]-1H-pyrazol-1-yl}benzonitrile
(2006) Bustos, Carlos; Schott Verdugo, Eduardo Enrique; Mac-Leod-Carey, Desmond A.; Ibañez, Andres; Alvarez-Thon, Luis
7-(tert-Butyldiphenylsilyloxy)-2,2-dimethyl-1-benzofuran-3(2H)-one
(2011) Salas Sánchez, Cristián Osvaldo; Tapia Apati, Ricardo; Macias, Alejandro
A 12-point checklist for surveillance of diseases of aquatic organisms: a novel approach to assist multidisciplinary teams in developing countries
(2021) Bondad Reantaso, Melba G.; Fejzic, Nihad; MacKinnon, Brett; Huchzermeyer, David; Seric Haracic, Sabina; Mardone, Fernando O.; Vishnumurthy Mohan, Chadag; Taylor, Nick; Jansen, Mona Dverdal; Tavornpanich, Saraya; Hao, Bin; Huang, Jie; Leaño, Eduardo M.; Li, Qing; Liang, Yan; Dall’occo, Andrea

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