Publicaciones académicas

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https://repositorio.uc.cl/handle/11534/7
Esta colección incluye artículos de profesores de la Pontificia Universidad Católica de Chile, publicados en revistas nacionales y extranjeras.

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Browsing Publicaciones académicas by browse.metadata.categoriaods "03 03 Salud y bienestar"

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    COVID-19, Autism, and Isolation: Good Practices for Continuity of Care During the Pandemic
    (2025) Cuesta Gómez, José L.; Ruggieri, Víctor; Roman Urrestarazu, Andrés; Kessel, Robin van; Gatica Bahamondes, Gabriel Guillermo
    The COVID-19 pandemic, and particularly the associated conditions of isola-tion, has detrimental effects on the mental health of the population that arenot yet fully understood. Variables such as individual stress, anxiety, andtolerance to uncertainty may play a role in the ability of individuals to adaptto the isolation situation. In this context, it is necessary to pay attention topopulation groups that present difficulties in adapting to this situation ofuncertainty, such as people with autism. This narrative review of the evi-dence has as objectives to explore (1) the effect that the autism communityhas experienced as a result of the lockdown and isolation due to COVID-19;and (2) opportunities for health, educational, and social services providers tosupport people with autism and their families in isolation in an attempt toensure that specialized interventions continue as much as possible. We mapsuggestions regarding information delivery, time management at home,recognition and emotional expression, and some suggestions to maintainsupport with service providers
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    El rol de la investigación en nutrición y alimentos, y la academia, en el cumplimiento de la Agenda 2030 para el Desarrollo Sostenible
    (2024) Fredes González, Carolina Paz; Echeverria González, Francisca Cecilia; Fernández-Verdejo, Rodrigo
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    Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans
    (2025) Silickas, Justinas; Smith, Alberto; Andía Kohnenkampf, Marcelo Edgardo; Botnar, René Michael; Modarai, Bijan; Karunanithy, Narayan; Patel, Ashish S.; Black, Stephen; Saha, Prakash; Phinikaridou, Alkystis
    Background:Randomized trials of venous thrombolysis to prevent postthrombotic syndrome have produced mixed results. A method to identify patients most likely to benefit from interventional treatment is needed. This study evaluated a contrast-free, magnetic resonance-based multisequence thrombus imaging (MSTI) technique to characterize deep venous thrombi and predict susceptibility to thrombolysis.Methods:Venous thrombosis was induced in the inferior vena cava of BALB/C mice (n=56, male), which were imaged up to 28 days postsurgery and 24 hours after systemic thrombolysis (Actilyse, 10 mg/kg, IV). The prelysis MSTI protocol included 3-dimensional T1 mapping, 3-dimensional magnetization transfer, and 2-dimensional diffusion-weighted imaging. Thrombolysis was defined as successful if inferior vena cava blood flow increased by ≥50% compared with prelysis values. In a clinical cohort, 41 patients with acute iliofemoral deep venous thrombi underwent MSTI before catheter-directed thrombolysis. Imaging parameters were analyzed against postintervention outcomes.Results:MSTI identified thrombi susceptible to thrombolysis in both mice and humans. In mice, lysed thrombi showed lower T1 (723 [667–782] versus 874 [799–1000] ms; P<0.001) and higher apparent diffusion coefficient values (1.02 [0.96–1.14] versus 0.78 [0.62–0.88]×10-³ mm²/s; P<0.001) than nonlysable thrombi, with no difference in magnetization transfer. In patients, lysed thrombi demonstrated lower T1 (606 [543–656] versus 765 [630–909] ms; P<0.001), lower apparent diffusion coefficient (0.67 [0.5–1.1] versus 1.23 [0.69–1.74]×10-³ mm²/s; P=0.001), and similar magnetization transfer rates. Combining MSTI parameters optimized prediction, achieving 88% sensitivity and 97% specificity in mice, and 86% sensitivity and 91% specificity in humans.Conclusions:MSTI enables noninvasive, contrast-free characterization of thrombus composition and predicts thrombolytic susceptibility. This technique has the potential to guide patient selection for invasive therapies and should be incorporated into future trials of venous thrombosis treatment.