Browsing by Author "Tapia Illanes, José Luis"

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    A new score for predicting neonatal very low birth weight mortality risk in the NEOCOSUR South American Network
    (NATURE PUBLISHING GROUP, 2005) Marshall Rivera, Guillermo; Tapia Illanes, José Luis; D'Apremont Ormeño, Ivonne; Grandi, C.; Barros, C.; Alegri, A.; Fabres Biggs, Jorge Guillermo; Standen, J.; Panizza, R.; Roldán, L.; Musante, G.; Bancalari, A.; Bambaren, E.; Lacarruba J.; Hubner M. E.; Decaro, M.; Maríani, G.; Kurlat, I.; González, A.
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    A risk prediction model for severe intraventricular hemorrhage in very low birth weight infants and the effect of prophylactic indomethacin
    (2014) Luque, M.; Tapia Illanes, José Luis; Villarroel del Pino, Luis A.; Marshall Rivera, Guillermo; Musante, G.; Carlo, W.; Kattan Said, Alberto Javier
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    An assessment of the severity, proportionality and risk of mortality of very low birth weight infants with fetal growth restriction. A multicenter South American analysis
    (2005) Grandi, Carlos; Tapia Illanes, José Luis; Marshall Rivera, Guillermo; Musante, G.; Kurlat, I.; Mariani, G.; Roldán, L.; Agost, D.; Grandi, C.; Decaro, M.; Estay Navarrete, Alberto Santiago; Ramírez, R.; Bancalari, A.; Standen, J.; González, A.; Alegria, A.; Lacarruba, J. M.; Zegarra, J.; Panizza, R.
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    Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study
    (2024) Vaz Ferreira, Catalina; Caro, Jose; Villarroel del Pino, Luis A.; Muñoz, Sergio; Álvarez, Patricia; Flores, Gerardo; Herrera, Tamara; Toso, Alberto; Toso Milos, Paulina Alejandra; Tapia Illanes, José Luis; NEOCOSUR Neonatal Network
    Objective: To explore the association between antenatal magnesium sulfate (MgSO4), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants. Study design: Retrospective, cohort study of infants <32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO4. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities. Results: 7418 VLBW infants were eligible. Antenatal MgSO4 was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49–0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50–0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72–1.71]). No differences between groups were observed in rates of morbidities. Conclusion: Antenatal MgSO4 was associated with a decreased death rate after admission and in severe IVH/ death.
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    Bronchopulmonary dysplasia: Incidence, risk factors and resource utilization in a population of South American very low birth weight infants
    (2006) Tapia Illanes, José Luis; Agost, Daniel; Alegria, Angélica; Standen, Jane; Escobar, Marisol; Grandi, Carlos; Musante, Gabriel; Zegarra, Jaime; Estay Navarrete, Alberto Santiago; Ramírez, Rodrigo; Prudent, L.; Alazrraqui, M.; Kurlat, I.; Di Siervi, O.; Azcárate, A.; Mariani, G.; Fernández, S.; Ceriani, J. M.; Roldán, L.; Sexer, H.; Tavosnanska, J.
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    Corticoides postnatal y displasia broncopulmonar: Beneficios versus riesgos
    (2003) Tapia Illanes, José Luis; Kattan Said, Alberto Javier
    In the last decade there has been an important decrease in the neonatal mortality of very low birth weight premature infants. However, bronchopulmonar dysplasia (BPD) is the most frequent chronic sequelae in survivors. Inflammation plays a key role in its pathogenesis and provides the reason why postnatal steroid administration has deserved an important role, not only in research but its increasing use in NICUs. The aim of this article is to review the published evidence of the risks and benefits of steroid therapy in each postnatal age group. With early steroid use (< 72 hours after birth), for each 10 patients treated one case of BPD can be revented, but at the cost of acute complications, such as, intestinal perforation, arterial hypertension and hypertrophic cardiomyopathy. Its late use facilitates extubation and decreases oxygen requirements at 36 weeks (corrected age), but has been associated with growth failure and arterial hipertension. What is of more concern is the observed effect of systemic steroids in neurodevelopment, with a greater risk of developing motor dysfunction and cerebral palsy. It has been estimated that for 30 patients treated with steroids there will be 4 extra cases of cerebral palsy. In summary, there is growing evidence that the long term consequences of postnatal steroid administration outweigh the short term benefits. It therefore should be restricted to carefully selected cases, using lower doses and for shorter durations than currently employed.
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    Estimation of individual neonatal survival using birthweight and gestational age : A way to improve neonatal care
    (BMC, 2008) Mardones S., Francisco; Marshall Rivera, Guillermo; Viviani García, Paola; Villarroel del Pino, Luis A.; Mardones Restat, Francisco; Tapia Illanes, José Luis; Cerda Lorca, Jaime Rodrigo; Garcia Huidobro, Trinidad; Ralph, Constanza; Oyarzún Ebensperger, Enrique
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    Factors associated with survival and survival without major morbidity in very preterm infants in two neonatal networks: SEN1500 and NEOCOSUR
    (S. Karger A.G., 2021) García-Muñoz Rodrigo, Fermín; Fabres Biggs, Jorge Guillermo Eduardo; Tapia Illanes, José Luis; D'apremont Ormeño, Ivonne; San Feliciano, Laura; Zozaya Nieto, Carlos; Figueras Aloy, Josep; Mariani, Gonzalo; Musante, Gabriel; Silvera, Fernando; Zegarra, Jaime; Vento, Máximo
    Introduction: Very low-birth weight (VLBW) infants represent a high-risk population for morbidity and mortality in the neonatal period. Variability in practices and outcomes between centers has been acknowledged. Multicenter benchmarking studies are useful to detect areas of improvement and constitute an interesting research tool. Objectives: The aim of the study was to determine the perinatal variables and interventions associated with survival and survival without major morbidity in VLBW infants and compare the performance of 2 large networks. Methods: This is a prospective study analyzing data collected in 2 databases, the Spanish SEN1500 and the South American NEOCOSUR networks, from January 2013 to December 2016. Inborn patients, from 24(0) to 30(6) weeks of gestational age (GA) were included. Hazard ratios for survival and survival without major morbidity until the first hospital discharge or transfer to another facility were studied by using Cox proportional hazards regression. Results: A total of 10,565 patients, 6,120 (57.9%) from SEN1500 and 4,445 (42.1%) from NEOCOSUR, respectively, were included. In addition to GA, birth weight, small for gestational age (SGA), female sex, and multiple gestation, less invasive resuscitation, and the network of origin were significant independent factors influencing survival (aHR [SEN1500 vs. NEOCOSUR]: 1.20 [95% CI: 1.15-1.26] and survival without major morbidity: 1.34 [95% CI: 1.26-1.43]). Great variability in outcomes between centers was also found within each network. Conclusions: After adjusting for covariates, GA, birth weight, SGA, female sex, multiple gestation, less invasive resuscitation, and the network of origin showed an independent effect on outcomes. Determining the causes of these differences deserves further study.
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    Incidence of bronchopulmonary dysplasia
    (SOCIEDAD CHILENA DE PEDIATRIA, 1990) Tapia Illanes, José Luis; Sánchez Díaz, Ignacio; Lara S., Ximena; Aguayo D., Gloria
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    Mechanical ventilation and survival without major morbidities in Very-Low-Birth-Weight Infants: a multicenter study
    (2023) Toso, Alberto; Kuzmanic, Daniela; Domínguez, Angélica; González, Álvaro; Herbozo, Cecilia; Brener Dik, Pablo Hernán; Ahumada, Luis Alberto; Méndez, Álvaro; Aburto, Claudia; Tapia Illanes, José Luis
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    Mortality in very low birth weight (VLBW) infants in South American NEOCOSUR Neonatal Network: timing and causes
    (2022) Toso, Alberto; Vaz Ferreira, C.; Herrera, T.; Villarroel del Pino, Luis A.; Brusadin, M.; Escalante Rivas, María José; Masoli, Daniela; D'Apremont, Ivonne; Tapia Illanes, José Luis; Mariani, G.
    Sociedad Argentina de Pediatría.INTRODUCTION: Mortality in very low birth weight infants (VLBWIs) has remained at ~26% in the past 16 years in the NEOCOSUR Neonatal Network. OBJECTIVE: Mortality in very low birth weight infants (VLBWIs) has remained at ~26% in the past 16 years in the NEOCOSUR Neonatal Network. POPULATION AND METHODS: Observational, multicenter cohort study; retrospective analysis of data collected prospectively. Newborn infants born between 24 and 31+6 weeks of gestation age with a birth weight between 500 and 1500 g in the 26 sites of the NEOCOSUR Neonatal Network were included. The causes of death were analyzed depending on whether they occurred in the delivery room (DR) or in the neonatal intensive care unit (NICU). The postnatal age at time of death was determined using the KaplanMeier test. RESULTS: Observational, multicenter cohort study; retrospective analysis of data collected prospectively. Newborn infants born between 24 and 31+6 weeks of gestation age with a birth weight between 500 and 1500 g in the 26 sites of the NEOCOSUR Neonatal Network were included. The causes of death were analyzed depending on whether they occurred in the delivery room (DR) or in the neonatal intensive care unit (NICU). The postnatal age at time of death was determined using the KaplanMeier test. CONCLUSIONS: Important differences were observed in the causes of death of VLBWIs depending on their occurrence in the DR or the NICU. Infectious and respiratory conditions were the most relevant factors following admission to the NICU.Introducción. La mortalidad de los recién nacidos de muy bajo peso de nacimiento (RNMBPN) se ha mantenido en ~26 % en los últimos 16 años en la Red Neonatal NEOCOSUR. Objetivo. Determinar la causa de muerte de los RNMBPN y su temporalidad en el período 20072016 en la Red Neonatal NEOCOSUR. Población y métodos. Estudio observacional de cohorte multicéntrica; análisis retrospectivo de datos obtenidos prospectivamente. Se incluyeron recién nacidos entre 24 y 31+6 semanas de edad gestacional y peso de nacimiento de 500-1500 g, en 26 centros de la Red Neonatal NEOCOSUR. Las causas de muerte se analizaron según ocurriera en sala de partos (SP) o durante la estadía en la unidad de cuidados intensivos neonatales (UCIN). La edad posnatal de muerte se determinó a través de análisis de Kaplan-Meier. Resultados. Se incluyeron un total de 11753 RNMBPN con una mortalidad global del 25,6 %. Las causas de muerte predominantes en SP fueron malformaciones congénitas (43,3 %), enfermedades respiratorias (14,3 %) y prematuridad (11,4 %). Las causas de muerte predominantes en UCIN fueron las respiratorias (24,2 %) e infecciosas (24,1 %). La edad promedio de muerte fue de 10,2 días y mediana de 4 días. El 10,2 % de las muertes ocurrieron en SP; el 21,5 %, durante el primer día; el 52 % ocurrió en los primeros 4 días y el 63,8 %, durante la primera semana de vida. , A través de los años, la mortalidad de los recién nacidos de muy bajo peso de nacimiento (RNMBPN) se ha mantenido estable, en torno al 26 % en la Red Neonatal NEOCOSUR.1 Esta mortalidad es mayor que la reportada por otras redes neonatales de países desarrollados. Así, los datos de la Red Suiza dan cuenta de una mortalidad de solo un 11 % entre los años 2012 a 2014 para el mismo grupo de recién nacidos.2 La red internacional iNEO, que agrupa 10 redes a lo largo del mundo, describe una mortalidad global del 9,1 % en RNMBPN de entre 24 a 32 semanas de edad gestacional entre los años 2007 y 2015.3 Por otra parte, la Red Neonatal Brasilera informa una mortalidad de 30 % en RNMBPN.4 f. Red Neonatal del Cono Sur (www. neocosur.org). Correspondencia: Alberto Toso: aatoso@ uc.cl Financiamiento: Ninguno. Conflicto de intereses: Ninguno que declarar. Recibido: 12-8-2021 Aceptado: 12-1-2022 Conclusiones. Se encuentran importantes diferencias en las causas de muerte de RNMBPN según ocurra en SP o en UCIN. Las infecciosas y respiratorias son las más relevantes luego del ingreso a la unidad de cuidados intensivos.
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    Neonatal polycythemia. Review of 110 cases
    (SOCIEDAD CHILENA DE PEDIATRIA, 1988) Rivera Martínez, Walter; Sánchez Díaz, Ignacio; Cavagnaro Santa María, Carlos Felipe Gonzalo; Winter Garcés, Augusto; Tapia Illanes, José Luis; Juez García, Gabriela
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    Relation of the brachial perimeter and some indicators of intrauterine growth
    (SOCIEDAD CHILENA DE PEDIATRIA, 1988) Sánchez Díaz, Ignacio; Cavagnaro Santa María, Carlos Felipe Gonzalo; Tapia Illanes, José Luis; Juez García, Gabriela
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    Survival and morbidity of very low birth weight infants in a South American Neonatal Network
    (2014) Fernández, R.; D'Apremont, I.; Domínguez, A.; Tapia Illanes, José Luis; Estay Navarrete, Alberto Santiago; González, A.; Quezada, M.; Urzúa Baquedano, María Soledad; Kattan Said, Alberto Javier; Rojas, S; Vignes, S.; Marshall Rivera, Guillermo; Villarroel del Pino, Luis A.
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    The unfinished work of neonatal very low birthweight infants quality improvement: Improving outcomes at a continental level in South America
    (2021) Tapia Illanes, José Luis; Toso, Alberto; Vaz Ferreira, C.; Fabres Biggs, Jorge Guillermo Eduardo; Musante, G.; Mariani, G.; Herrera, T., I; D'Apremont, Ivonne
    Neonatal mortality rate varies between 4.2 and 18.6 per thousand by country in South America. There is little information regarding the outcomes of very low birth weight infants in the region and mortality rates are extremely variable ranging from 6% to over 50%. This group may represent up to 50-70% of the neonatal mortality and approximately 25-30% of infant mortality. Some initiatives, like the NEOCOSUR Network, have systematically collected and analyzed epidemiological information on VLBW infants' outcomes in the region. Over a 16-year period, survival without major morbidity improved from 37 to 44%. However, mortality has remained almost unchanged at approximately 27%, despite an increase in the implementation of the best available evidence in perinatal practices over time. Implementing quality improvement initiatives in the continent is particularly challenging but represents a great opportunity considering that there is a wide margin for progress in both care and outcomes.
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    Trends in Perinatal Practices and Neonatal Outcomes of Very Low Birth Weight Infants during a 16-year Period at NEOCOSUR Centers
    (2020) D'Apremont Ormeño, Ivonne; Marshall Rivera, Guillermo; Musalem, C.; Mariani, G.; Musante, G.; Bancalari, A.; Fabres Biggs, Jorge Guillermo; Mena Nannig, Patricia Isabel; Villarroel del Pino, Luis A.; Tapia Illanes, José Luis; Zegarra, J.; Tavosnanska, J.; Lacarrubba, J.; Solana, C.; Ferreira, C. V.; Herrera, T.