Browsing by Author "Saitz, Claudio"
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- ItemSolvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity(PERGAMON-ELSEVIER SCIENCE LTD, 2008) Pessoa Mahana, Hernan; Kosche, Johann; Ron, Nadia; Recabarren Gajardo, Gonzalo; Saitz, Claudio; Araya Maturana, Rarniro; Pessoa Mahana, DavidA novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).
- ItemSynthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential Ligands with 5-HT1A binding affinity(TAYLOR & FRANCIS INC, 2007) Pessoa Mahana, Hernan; Acevedo, R.; Araya Maturana, Ramiro; Saitz, Claudio; Pessoa Mahana, C. DavidNew benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl]-4,7-dimethoxybenzo[b]thiophene-2-carboxamide (7) with a series of substituted 4-arylpiperazines.