Browsing by Author "Rigotti Rivera, Attilio"

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    Abnormalities of lipid metabolism, gallstone disease and gallbladder function
    (2011) Zanlungo Matsuhiro, Silvana; Miquel P., Juan Francisco; Rigotti Rivera, Attilio; Nervi, Flavio
    Gallstone disease is highly prevalent with a complex and multifactorial pathogenesis. Gallstones are closely related to the metabolic syndrome associated disease conditions in which abnormal regulation of lipid metabolism secondary to insulin resistance plays a major pathogenic role. Insulin resistance increases biliary cholesterol secretion and affects gallbladder (GB) motility. Regulation of lipid metabolism and energy homeostasis is complex and the GB has been considered to have a minor regulatory role in both the intestinal absorption of lipids and metabolic homeostasis of the whole body. In fact, ablation of the GB does not affect nutrient absorption or the ability to lead a normal life. GB function regulates the cycling of bile salts through the enterohepatic circulation. Bile salts have important signaling effects that can affect whole body metabolic homeostasis. The GB and intestinal mucosa are rich in the hormone FGF15/19 and the receptor TGR5, which participate in metabolic regulation. Recent evidence supports the hypothesis that cholecystectomy may not be innocuous and that the GB has a significant role in the regulation of hepatic triglyceride metabolism. This article provides information regarding recent advances in the understanding of the interaction between regulation of lipid metabolism, insulin resistance, gallstone disease and GB function.
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    El ácido nicotínico aumenta el transporte celular de colesterol de las lipoproteínas de alta densidad en pacientes con hipoalfalipoproteinemia
    (2015) Figueroa, Catalina; Droppelmann Droppelmann, Katherine Ann; Quinones, Verónica; Amigo Boker, Ludwig Peter; Mendoza, Camila; Serrano Larrea, Valentina; Véjar, Margarita; Maiz Gurruchaga, Manuel Alberto; Rigotti Rivera, Attilio
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    Active Transportation and Obesity Indicators in Adults from Latin America : ELANS Multi-Country Study
    (2020) Guzmán Habinger, J.; Lobos Chávez, J.; Mahecha Matsudo, S.; Kovalskys, I.; Gómez, G.; Rigotti Rivera, Attilio; Cortés Sanabria, L. Y.; Yépez García, M. C.; Pareja, R. G.; Herrera Cuenca, M.; Zimberg, I. Z.; Guajardo, V.; Pratt, M.; Cofre Bolados, C.; Farías Valenzuela, C.; Marques, A.; Peralta, M.; Leme, A. C. B.; Fisberg, M.; Oliveira Werneck, A.; Rodrigues da Silva, D.; Ferrari, G.
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    Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice
    (2007) Cortés, V.; Zanlungo Matsuhiro, Silvana; Brandan, Enrique; Rigotti Rivera, Attilio
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    Advances in the physiological and pathological implications of cholesterol
    (2013) Cortés Mora, Víctor Antonio; Busso, Dolores; Mardones, Pablo; Maiz Gurruchaga, Manuel Alberto; Arteaga Ll., Antonio; Nervi, Flavio; Rigotti Rivera, Attilio
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    Una alimentación poco saludable se asocia a mayor prevalencia de síndrome metabólico en la población adulta chilena : estudio de corte transversal en la Encuesta Nacional de Salud 2009-2010
    (2015) Dussaillant, Catalina; Echeverria, Guadalupe; Villarroel del Pino, Luis A.; Marín Larraín, Pedro Paulo; Rigotti Rivera, Attilio
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    Anthropometry, dietary intake, physical activity and sitting time patterns in adolescents aged 15–17 years: an international comparison in eight Latin American countries
    (2020) Ferrari, Gerson Luis de Moraes.; Rigotti Rivera, Attilio; Kovalskys, I.; Fisberg, M.; Gómez, G.; Cortés Sanabria, L. Y.; Yépez Garcí­a, M. C.; Pareja Torres, R. G.; Herrera-Cuenca, M.; Zalcman Zimberg, I.
    Abstract Background Although there is high prevalence of obesity and other cardiovascular risk factors among Latin American adolescents, there is limited evidence on dietary intake and physical activity (PA) patterns in this population. Therefore, we characterized anthropometry, dietary intake, PA and sitting time (ST) in adolescents aged 15–17 years from eight Latin American countries. Methods Six hundred seventy-one adolescents (41.4% girls) from the Latin American Study of Nutrition and Health (ELANS) were included. Nutritional status was classified by four BMI (kg/m2) categories. Waist circumference (WC) was categorized as above or below thresholds. Dietary intake was assessed through two non-consecutive 24-h dietary recalls. PA and ST were measured using the International Physical Activity Questionnaire (IPAQ). We calculated overall and country-specific estimates by sex and tested for differences between boys and girls. Results Differences in the prevalence of overweightness (15.1 and 21.6%) and obesity (8.5 and 6.5%) between boys and girls, respectively, were statistically insignificant (p = 0.059). Average energy intake was 2289.7 kcal/day (95% CI: 2231–2350) for boys and 1904.2 kcal/day (95% CI: 1840–1963) for girls (p < 0.001). In relation to macronutrient intake for boys and girls, respectively, the average intake (expressed as percentage of total energy) was 15.0 and 14.9% for protein; 55.4 and 54.9% for carbohydrates; 14.1 and 14.5% for added sugar; 29.5 and 30.1% for total fat; and 9.6 and 9.9% for saturated fat (p > 0.05 for all outcomes). There was no statistically significant difference in the prevalence of total energy (TE) saturated fat and added sugar (>10% of TE) between girls and boys (49.6% versus 44.8 and 81.7% versus 76.1%, respectively). Prevalence of physical inactivity was 19% in boys and 43.7% in girls (p < 0.001). Median levels of vigorous-intensity PA and total PA were significantly higher for boys than for girls (p < 0.05 for both outcomes); whereas levels of ST were similar (273.7 versus 220.0 min/day for boys and girls, respectively; p > 0.05). Conclusions These findings highlight the high prevalence of poor dietary intake and physical inactivity in adolescents from Latin American countries. Therefore, effective and sustainable strategies and programmes are needed that promote healthier diets, regular PA and reduce ST among Latin American adolescents. Trial registration Clinical Trials NCT02226627. Retrospectively registered on August 27, 2014.
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    APOA5 Q97X Mutation Identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family
    (2012) Dussaillant, Catalina; Serrano Larrea, Valentina; Maiz Gurruchaga, Manuel Alberto; Eyheramendy Duerr, Susana; Cataldo Bascuñan, Luis Rodrigo; Smalley Meylan, Susan Valerie; Rigotti Rivera, Attilio; Rubio, Lorena.; Lagos Arévalo, Carlos Fernando; Santos Martín, José Luis
    Abstract Background Severe hypertriglyceridemia (HTG) has been linked to defects in LPL, APOC2, APOA5, LMF1 and GBIHBP1 genes. However, a number of severe HTG cases are probably caused by as yet unidentified mutations. Very high triglyceride plasma levels (>112 mmol/L at diagnosis) were found in two sisters of a Chilean consanguineous family, which is strongly suggestive of a recessive highly penetrant mutation. The aim of this study was to determine the genetic locus responsible for the severe HTG in this family. Methods We carried out a genome-wide linkage study with nearly 300,000 biallelic markers (Illumina Human CytoSNP-12 panel). Using the homozygosity mapping strategy, we searched for chromosome regions with excess of homozygous genotypes in the affected cases compared to non-affected relatives. Results A large homozygous segment was found in the long arm of chromosome 11, with more than 2,500 consecutive homozygous SNP shared by the proband with her affected sister, and containing the APOA5/A4/C3/A1 cluster. Direct sequencing of the APOA5 gene revealed a known homozygous nonsense Q97X mutation (p.Gln97Ter) found in both affected sisters but not in non-affected relatives nor in a sample of unrelated controls. Conclusion The Q97X mutation of the APOA5 gene in homozygous status is responsible for the severe hypertriglyceridemia in this family. We have shown that homozygosity mapping correctly pinpointed the genomic region containing the gene responsible for severe hypertriglyceridemia in this consanguineous Chilean family.
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    Apolipoprotein A-I deficiency does not affect biliary lipid secretion and gallstone formation in mice
    (2011) Amigo Boker, Ludwig Peter; Quiñones, Verónica; Leiva Mendoza, Andrea Alejandra; Busso, Dolores; Zanlungo Matsuhiro, Silvana; Nervi, Flavio; Rigotti Rivera, Attilio
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    Are the diferent cut-of points for sitting time associated with excess weight in adults?: a population based study in Latin America
    (2023) Victo, Eduardo Rossato de; Kovalskys, Irina; Fisberg, Mauro; Gómez, Georgina; Rigotti Rivera, Attilio; Cortés, Lilia Y.; Yépez García, Martha; Pareja, Rossina G.; Herrera Cuenca, Marianella; Solé, Dirceu; Drenowatz, Clemens; Marques, Adilson; Ferrari, Gerson
    Background: Excess weight is increasing worldwide, and in Latin America more than half of the population is excess weight. One of the reasons for this increase has been excessive sitting time. Still, it remains to be seen whether there is an excessive amount of that time in Latin American adults. This study aimed to associate different sitting time cut-off points with the excess weight. Methods: Data from the Latin American Study of Nutrition and Health (ELANS), a cross-sectional population-based survey conducted in eight Latin American countries, were used. The excess weight indicators used were body mass index, and waist and neck circumferences. Sitting time was obtained using questionnaires and categorized at different cut-off points. Differences between sitting time categories (< 4 or ≥ 4; < 6 or ≥ 6; and < 8 or ≥ 8 hours/day) and excess weight were obtained by Student’s t test for independent samples and the association between sitting time categories and different indicators of excess weight were obtained by logistic regression. Results: The median of the sitting time was 420 min/day (IQR: 240–600). There were no significant differences between body mass index (kg/m2) and waist circumference (cm) with categories of sitting time. The mean values of neck circumference (cm) were significantly higher in ≥4, ≥6 and ≥ 8 hours/day than < 4, < 6, and < 8 hours/day of sitting time in the pooled sample. Some distinct differences by country were observed. There were significant differences among excess weight by body mass index (63.2% versus 60.8) with < 8 vs ≥8 hours/day of sitting time. The proportion of excess weight by neck circumference was higher in participants who reported ≥4, ≥6, and ≥ 8 hours/day compared to < 4, < 6, and < 8 hours/day of sitting time. Considering ≥8 hours/day of sitting time, higher odds of excess weight were found evaluated by body mass index (OR: 1.10; 95% CI: 1.01, 1.20) and neck circumference (OR: 1.13; CI 95%: 1.03, 1.24) overall. Conclusions: Sitting time above 8 hours/day was associated with higher odds of excess weight, even though there were no differences in waist circumference between sitting time categories.
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    Asociación entre bienestar psicológico y adherencia a dieta mediterránea en pacientes chilenos con síndrome metabólico
    (2023) Mateo Hernández, Camila; Berkowitz Fiebich, Loni; Rigotti Rivera, Attilio; Pontificia Universidad Católica de Chile. Escuela de Medicina
    Un estilo de vida mediterráneo abarca aspectos físicos, psicológicos y sociales. La dieta mediterránea ha demostrado evidencia sustancial sobre sus beneficios cardiometabólicos, pero cuenta con pocos estudios de calidad que integren al bienestar psicológico en su evaluación y análisis. Por otra parte, existe evidencia que relaciona la promoción de estados psicológicos positivos a una mayor adherencia a comportamientos de estilo de vida saludables. En base a esto, la hipótesis de este proyecto postula que aquellos individuos con mayor bienestar psicológico tendrán mayor adherencia a dieta mediterránea, y viceversa. Esta propuesta se enmarca en el proyecto ChileMed, investigación que estudia la relación sinérgica entre una intervención nutricional basada en dieta mediterránea y una intervención psicológica centrada en el bienestar, sobre la prevención de enfermedades crónicas en pacientes chilenos con síndrome metabólico. Como objetivo principal, se buscó determinar si existe una asociación basal entre los niveles de bienestar psicológico y adherencia a dieta mediterránea en pacientes chilenos con síndrome metabólico; y como objetivo secundario, determinar si posterior a la intervención en bienestar psicológico se logra aumentar la adherencia a dieta mediterránea a mediano plazo (6 meses) en estos individuos. Se utilizaron datos de aquellos participantes reclutados desde agosto de 2021 hasta septiembre de 2022 al inicio del estudio y secundariamente a un subgrupo con seguimiento a 6 meses de las intervenciones. Para medir el bienestar psicológico, se utilizaron las escalas de Ryff y para medir adherencia a dieta mediterránea se aplicó el índice chileno de dieta mediterránea. Para el análisis estadístico, se realizaron regresiones lineales y comparaciones mediante ANOVA de dos vías con medidas repetidas. Como resultado, se obtuvo una asociación positiva leve entre bienestar psicológico y adherencia a dieta mediterránea a nivel basal, perdió significancia estadística después de corregir por la edad. Tras el período de seguimiento a 6 meses del inicio de la intervención, se observó una tendencia a mayor adherencia al patrón de alimentación mediterráneo en el grupo manejado con dieta mediterránea más bienestar versus la intervención nutricional aislada, pero se requiere un mayor tamaño muestral para alcanzar la significancia estadística. En conclusión, es relevante continuar investigando el rol del bienestar sobre los cambios de estilo de vida como potencial punto de apoyo en la prevención de enfermedades crónicas.
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    Asociación entre diabetes mellitus y patología cardiovascular en la población adulta de Chile : Estudio de la Encuesta Nacional de Salud 2009-2010
    (2014) Arteaga Ll., Antonio; Maiz, A.; Rigotti Rivera, Attilio; Cortés Mora, Víctor Antonio
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    Association between Perceived Neighborhood Built Environment and Walking and Cycling for Transport among Inhabitants from Latin America : The ELANS Study
    (2020) Ferrari, Gerson; Oliveira Werneck, A.; Rodrigues da Silva, D.; Kovalskys, Irina; Gómez, Georgina; Rigotti Rivera, Attilio; Cortés Sanabria, L. Y.; Yépez García, M. C.; Pareja, Rossina G.; Herrera Cuenca, M.; Zimberg, I. Z.; Guajardo, V.; Pratt, M.; Cofre Bolados, C.; Jofré Saldia, E.; Pires, C.; Marques, A.; Peralta, M.; Victo, Eduardo Rossato de; Fisberg, Mauro
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    Association of moderate-to-vigorous physical activity with neck circumference in eight Latin American countries
    (2019) Luis de Moraes Ferrari, Gerson; Kovalskys, Irina; Fisberg, Mauro; Gomez, Georgina; Rigotti Rivera, Attilio; Sanabria, Lilia; García, Martha.; Torres, Rossina; Herrera-Cuenca, Marianella; Zimberg, Ioná Z.
    Abstract Background Physical activity is a cornerstone in the prevention and treatment of obesity. There are relatively few studies that explore the effect of accelerometer-determined moderate-to-vigorous physical activity (MVPA) on neck circumference (NC), most of them confined to single high-income countries. The present study investigated the association of accelerometer-determined MVPA with NC in adolescents and adults from eight Latin American countries, which are mostly upper-middle income countries. Methods The sample consisted of 2370 participants (47.8% male) from the Latin American Study of Nutrition and Health, a multicenter cross-sectional nutrition and health surveillance study of a nationally representative sample from eight Latin American countries (Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru, and Venezuela). Times (min/day) in MVPA (defined as time accumulated at ≥1952 activity counts/min) was assessed by ActiGraph GT3X+ accelerometer over 7 days. NC for adolescent was categorized as abnormal if circumference was > 34.5 cm for boys and > 31.25 for girls, whereas for adults the cut-off points for abnormal were > 39 cm for men and > 35 cm women. Multilevel logistic models, including country and region as random effects and adjusted for sex, age, socioeconomic level, and educational level, were used to study the association between MVPA and NC. Results The average time of MVPA was 34.88 min/day, ranging from 31.16 in Venezuela to 40.27 in Chile. Concerning NC, 37.0% of the sample was classified as having elevated NC. Chile was the country with the highest percentage of people with elevated NC (56.9%), and Colombia had the lowest percentage (24.8%). Overall, the MVPA (min/day) was associated with elevated NC (OR = 0.994, CI95% = 0.990–0.998). In Costa Rica and Peru, there were significant associations between MVPA and NC when analyzed by country. Conclusions The present study provided evidence of significant associations between MVPA and NC in adolescents and adults from Latin America, independent of sex, age, socioeconomic level, and educational level. This analysis of accelerometry data and NC represents the first examination of these associations in eight Latin America countries. Further research is required to understand the differences between countries in the observed associations. Trial registration ClinicalTrials.Gov NCT02226627 . Retrospectively registered on August 27, 2014.Abstract Background Physical activity is a cornerstone in the prevention and treatment of obesity. There are relatively few studies that explore the effect of accelerometer-determined moderate-to-vigorous physical activity (MVPA) on neck circumference (NC), most of them confined to single high-income countries. The present study investigated the association of accelerometer-determined MVPA with NC in adolescents and adults from eight Latin American countries, which are mostly upper-middle income countries. Methods The sample consisted of 2370 participants (47.8% male) from the Latin American Study of Nutrition and Health, a multicenter cross-sectional nutrition and health surveillance study of a nationally representative sample from eight Latin American countries (Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru, and Venezuela). Times (min/day) in MVPA (defined as time accumulated at ≥1952 activity counts/min) was assessed by ActiGraph GT3X+ accelerometer over 7 days. NC for adolescent was categorized as abnormal if circumference was > 34.5 cm for boys and > 31.25 for girls, whereas for adults the cut-off points for abnormal were > 39 cm for men and > 35 cm women. Multilevel logistic models, including country and region as random effects and adjusted for sex, age, socioeconomic level, and educational level, were used to study the association between MVPA and NC. Results The average time of MVPA was 34.88 min/day, ranging from 31.16 in Venezuela to 40.27 in Chile. Concerning NC, 37.0% of the sample was classified as having elevated NC. Chile was the country with the highest percentage of people with elevated NC (56.9%), and Colombia had the lowest percentage (24.8%). Overall, the MVPA (min/day) was associated with elevated NC (OR = 0.994, CI95% = 0.990–0.998). In Costa Rica and Peru, there were significant associations between MVPA and NC when analyzed by country. Conclusions The present study provided evidence of significant associations between MVPA and NC in adolescents and adults from Latin America, independent of sex, age, socioeconomic level, and educational level. This analysis of accelerometry data and NC represents the first examination of these associations in eight Latin America countries. Further research is required to understand the differences between countries in the observed associations. Trial registration ClinicalTrials.Gov NCT02226627 . Retrospectively registered on August 27, 2014.Abstract Background Physical activity is a cornerstone in the prevention and treatment of obesity. There are relatively few studies that explore the effect of accelerometer-determined moderate-to-vigorous physical activity (MVPA) on neck circumference (NC), most of them confined to single high-income countries. The present study investigated the association of accelerometer-determined MVPA with NC in adolescents and adults from eight Latin American countries, which are mostly upper-middle income countries. Methods The sample consisted of 2370 participants (47.8% male) from the Latin American Study of Nutrition and Health, a multicenter cross-sectional nutrition and health surveillance study of a nationally representative sample from eight Latin American countries (Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru, and Venezuela). Times (min/day) in MVPA (defined as time accumulated at ≥1952 activity counts/min) was assessed by ActiGraph GT3X+ accelerometer over 7 days. NC for adolescent was categorized as abnormal if circumference was > 34.5 cm for boys and > 31.25 for girls, whereas for adults the cut-off points for abnormal were > 39 cm for men and > 35 cm women. Multilevel logistic models, including country and region as random effects and adjusted for sex, age, socioeconomic level, and educational level, were used to study the association between MVPA and NC. Results The average time of MVPA was 34.88 min/day, ranging from 31.16 in Venezuela to 40.27 in Chile. Concerning NC, 37.0% of the sample was classified as having elevated NC. Chile was the country with the highest percentage of people with elevated NC (56.9%), and Colombia had the lowest percentage (24.8%). Overall, the MVPA (min/day) was associated with elevated NC (OR = 0.994, CI95% = 0.990–0.998). In Costa Rica and Peru, there were significant associations between MVPA and NC when analyzed by country. Conclusions The present study provided evidence of significant associations between MVPA and NC in adolescents and adults from Latin America, independent of sex, age, socioeconomic level, and educational level. This analysis of accelerometry data and NC represents the first examination of these associations in eight Latin America countries. Further research is required to understand the differences between countries in the observed associations. Trial registration ClinicalTrials.Gov NCT02226627 . Retrospectively registered on August 27, 2014.
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    Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice
    (2018) Contreras-Duarte, Susana; Chen, P.; Andía Kohnenkampf, Marcelo Edgardo; Uribe Arancibia, Sergio A.; Irarrázaval Mena, Pablo; Kopp, S.; Kern, S.; Marsche, G.; Busso, Dolores; Rigotti Rivera, Attilio
    Abstract Background and aims Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. In this study, we evaluated the role of vitamin C and E on non HDL lipoproteins as well as HDL function and remodeling, along with their effects on inflammation/oxidation biomarkers and atherosclerosis in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. Methods and results: Mice were pre-treated for 5 weeks before and during atherogenic diet feeding with vitamin C and E added to water and diet, respectively. Compared to a control group, combined vitamin C and E administration reduced serum total cholesterol and triglyceride levels by decreasing apo B-48-containing lipoproteins, remodeled HDL particles by reducing phospholipid as well as increasing PON1 and apo D content, and diminished PLTP activity and levels. Vitamin supplementation improved HDL antioxidant function and lowered serum TNF-α levels. Vitamin C and E combination attenuated atherogenesis and increased lifespan in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. Conclusions Vitamin C and E administration showed significant lipid metabolism regulating effects, including HDL remodeling and decreased levels of apoB-containing lipoproteins, in mice. In addition, this vitamin supplementation generated a cardioprotective effect in a murine model of severe and lethal atherosclerotic ischemic heart disease.
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    Calidad de alimentación en la población adulta chilena y su relación con el estado nutricional y síndrome metabólico en la Encuesta Nacional de Salud 2016-2017
    (2022) Saavedra Davids, Isidora; Echeverría Errázuriz, Guadalupe; Rigotti Rivera, Attilio; Pontificia Universidad Católica de Chile. Escuela de Medicina
    Introducción: En 2015, se creó un índice de dieta saludable (IDS-2015) que asoció la calidad dietética con prevalencia de SM en Chile en la Encuesta Nacional de Salud 2009-2019. Objetivo: Evaluar la calidad de la alimentación en población chilena estudiada en ENS 2016-2017, utilizando el IDS-2015 y su versión modificada en 2021 (IDS2021). Planteamos que una dieta más saludable evaluada por el IDS-2015 e IDS2021 se asocia a un mejor EN, menor prevalencia de SM y se relaciona positivamente con el interés por la lectura del etiquetado nutricional de los participantes. Métodos: Se analizaron 3.425 adultos, mayores de 18 años de edad, evaluados en la ENS 2016-2017 con información para diagnosticar SM según criterios ATPIIINCEP. Se utilizó el IDS-2015 y el IDS-2021, incluyendo tres nuevos alimentos, para analizar la calidad de la dieta y se asoció con la prevalencia de SM. Resultados: En ENS 2016-2017, el IDS-2015 arrojó un puntaje promedio de 1,35 puntos en la muestra actual (vs 1,29 puntos en ENS 2009-2010 (p<0,001)), demostrando nuevamente que el consumo de alimentos tiene mejor calidad en mujeres, a mayor edad y mayor nivel educacional. Una mejor calidad de la dieta, evaluada según el IDS-2015 y 2021, se relacionó significativamente con el interés por la lectura de la mayor parte del etiquetado nutricional, pero solo el IDS-2021 logro asociarse en forma significativa con el EN (b=-0,483, p=0,049). No se encontró relación entre la calidad de la dieta con la prevalencia y chance de SM en ENS 2016-2017 (p=0,851 y0,052, respectivamente). Conclusión: Si bien la calidad de la dieta mostró una mejoría desde 2009-2010 a 2016-2017 y se relacionó inversamente con el estado nutricional en la última ENS, esta sigue siendo deficiente, junto con una mayor prevalencia de sobrepeso, obesidad y SM en población adulta chilena. Por lo tanto, es importante realizar análisis permanentes de la calidad de alimentación e implementar nuevas iniciativas de cambios dietarios en Chile.
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    Childbearing age women characteristics in latin america. Building evidence bases for early prevention. Results from the Elans study
    (2021) Herrera Cuenca, M.; Previdelli, A. N.; Koletzko, B.; Hernández, P.; Landaeta Jiménez, M.; Sifontes, Y.; Gómez, G.; Kovalskys, I.; Yépez García, M. C.; Rigotti Rivera, Attilio; Pareja, R.; Cortés, L. Y.; Fisberg, M.
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    Cholesterol Levels and the Association of Statins With In-Hospital Mortality of Myocardial Infarction Patients Insights From a Chilean Registry of Myocardial Infarction
    (2013) Martínez, Gonzalo; Rigotti Rivera, Attilio; Acevedo B., Mónica; Navarrete, Carlos; Rosales Núñez, Juan Elizabeth; Giugliano, Robert P, Corbalán Herreros, Ramón
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    Comparison of self-report versus accelerometer - measured physical activity and sedentary behaviors and their association with body composition in Latin American countries
    (2020) Ferrari, Gerson; Kovalskys, Irina; Fisberg, Mauro; Gómez, Georgina; Rigotti Rivera, Attilio; Sanabria, L. Y. C.; Yépez García, Martha; Torres, R. G. P; Herrera Cuenca, Marianella; Zimberg, I.Z.; Guajardo, V.; Pratt, M.; Pires, C. A. M.; Colley, R. C.; Solé, Dirceu