Browsing by Author "Recabarren Gajardo, Gonzalo Iván"
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- ItemDesign, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands(2013) Espinosa Bustos, Christian; Iturriaga Vásquez, Patricio; Lagos, Carlos; Mella Raipán, Jaime; Pessoa Mahana, Carlos David; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Romero Parra, Javier HernánA series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinitie