DSpace Angular :: Browsing by Author "Ortiz Muñoz, Luis Eugenio"

Browsing by Author "Ortiz Muñoz, Luis Eugenio"

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Acupuntura para el dolor lumbar crónico inespecífico. Resumen Support de una revisión sistemática Cochrane
(2022) Gajardo, Gonzalo Alberto; Cortes-Jofré, Marcela; Ortiz Muñoz, Luis Eugenio; Pontificia Universidad Católica de Chile. Centro Evidencia UC
Este resumen SUPPORT pertenece a una revisión sistemática Cochrane. El dolor lumbar inespecífico crónico es afección muy común; se define como un dolor a nivel de la zona lumbosacra sin una etiología reconocible que dura más de tres meses. Algunas guías clínicas indican que la acupuntura puede ofrecer una terapia alternativa eficaz para el manejo del dolor.
Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trialsAngiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trials
(2021) Meza, Nicolás; Pérez-Bracchiglione, Javier; Pérez, Ignacio; Carvajal, Cristhian; Ortiz Muñoz, Luis Eugenio; Olguín, Pablo; Rada Giacaman, Gabriel Alejandro; Madrid, Eva
Objective: This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the evidence available on the role of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) in the treatment of patients with COVID-19. Data sources: We conducted searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralized repository in L·OVE (Living OVerview of Evidence), which retrieves articles from multiple sources such as PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Embase, among other pre-print and protocols repositories. In response to the COVID-19 emergency, L·OVE (Living OVerview of Evidence) was adapted to expand the range of evidence and customized to group all COVID-19 evidence in one place on a daily search basis. The search covered a period of time up to July 31, 2020. Eligibility criteria for selecting studies and methods: We adapted an already published standard protocol for multiple parallel living systematic reviews to this question's specificities. We included randomized trials evaluating the effect of either suspension or indication of angiotensin-converting-enzyme inhibitors or angiotensin II receptor blockers as monotherapy, or in combination versus placebo or no treatment in patients with COVID-19. We searched for randomized trials evaluating the effect of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers versus placebo or no treatment in patients with COVID-19. Two reviewers independently screened each study for eligibility, extracted data, and assessed the risk of bias. We pooled the results using meta-analysis and applied the GRADE system to assess the certainty of the evidence for each outcome. We will resubmit results every time the conclusions change or whenever there are substantial updates. Results: We screened 772 records, but none was considered for eligibility. We identified 55 ongoing studies, including 41 randomized trials evaluating angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers for patients with COVID-19. Conclusions: We did not find a randomized clinical trial meeting our inclusion criteria, and hence there is no evidence for supporting the role of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in the treatment of patients with COVID-19. A substantial number of ongoing studies would provide valuable evidence to inform researchers and decision-makers in the near future. PROSPERO registration number: CRD42020182495. Protocol preprint DOI: 10.31219/osf.io/vp9nj.Objetivo: Esta revisión sistemática viva tiene como objetivo proporcionar un resumen oportuno, riguroso y continuamente actualizado de la evidencia disponible sobre el rol de los inhibidores de la enzima convertidora de angiotensina (iECA) y los bloqueadores del receptor de angiotensina II (ARA-II) en el tratamiento de pacientes con COVID-19. Fuentes de datos: Realizamos búsquedas en PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), literatura gris y en el repositorio centralizado L·OVE (Living OVerview of Evidence) que recupera artículos de múltiples fuentes como PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Embase, entre otros repositorios de preprints y protocolos. En respuesta a la emergencia de COVID-19, L·OVE (Living OVerview of Evidence) se adaptó para ampliar el rango de información que cubre y se personalizó para agrupar toda la evidencia en torno a COVID-19 en un solo lugar, en una base de búsqueda diaria. La búsqueda cubrió el período hasta el 31 de julio de 2020. Criterios de elegibilidad para la selección de estudios y métodos: Adaptamos un protocolo común ya publicado para múltiples revisiones sistemáticas vivas paralelas a las especificidades de esta pregunta. Se incluyeron ensayos aleatorizados que evaluaban el efecto de la suspensión o la indicación de inhibidores de la enzima convertidora de angiotensina o bloqueadores de los receptores de angiotensina II, como monoterapia o en combinación, versus placebo o ningún tratamiento, en pacientes con COVID-19. Se buscaron ensayos aleatorizados que evaluaran el efecto de los inhibidores de la enzima convertidora de angiotensina/bloqueadores del receptor de angiotensina II versus placebo o ningún tratamiento en pacientes con COVID-19. Dos revisores examinaron de forma independiente la elegibilidad de cada estudio, extrajeron los datos y evaluaron el riesgo de sesgo. Los resultados se agruparon mediante un metanálisis y se aplicó GRADE para evaluar la certeza de la evidencia para cada resultado. Cada vez que cambien las conclusiones o hayan actualizaciones sustanciales, volveremos a enviar un reporte. Resultados: Analizamos 772 artículos, pero ninguno cumplió con los criterios de inclusión. Identificamos 55 estudios en curso, incluidos 41 ensayos aleatorizados que evaluaban inhibidores de la enzima convertidora de angiotensina/bloqueadores del receptor de angiotensina II para pacientes con COVID-19. Conclusiones: No encontramos ningún ensayo clínico aleatorizado que cumpliera con nuestros criterios de inclusión y, por lo tanto, no hay pruebas que respalden el papel de los inhibidores de la enzima convertidora de angiotensina y los bloqueadores de los receptores de angiotensina II en el tratamiento de pacientes con COVID-19. Identificamos un número considerable de estudios en curso que podría proporcionar evidencia valiosa para informar a los investigadores y a los responsables de la toma de decisiones en un futuro próximo.
Approaching the body of evidence: Key concepts of Overviews
(2023) Cruzat, Benjamin; Reveco-Guzman, Kimberly; Encina-Meneses, Matías; Ortiz Muñoz, Luis Eugenio; Bracchiglione, Javier
The increasing production of primary research and literature reviews in the last decades has made it necessary to develop a new methodological design to synthesize the evidence: the overviews. An overview is a type of evidence synthesis that uses systematic reviews as the unit of analysis, with the aim of extracting and analyzing the results for a new or broader research question, helping the shared decision-making processes. The aim of this article is to introduce the reader to this type of evidence summaries, high-lighting the differences between overviews and other types of synthesis, the unique methodological aspects of overviews, and future challenges. This is the twelfth article from a collaborative methodological series of narrative reviews about biostatistics and clinical epidemiology.
Approaching the body of evidence: Key concepts of Overviews
(2023) Cruzat, Benjamin; Reveco-Guzman, Kimberly; Encina-Meneses, Matías; Ortiz Muñoz, Luis Eugenio; Bracchiglione, Javier
The increasing production of primary research and literature reviews in the last decades has made it necessary to develop a new methodological design to synthesize the evidence: the overviews. An overview is a type of evidence synthesis that uses systematic reviews as the unit of analysis, with the aim of extracting and analyzing the results for a new or broader research question, helping the shared decision-making processes. The aim of this article is to introduce the reader to this type of evidence summaries, high-lighting the differences between overviews and other types of synthesis, the unique methodological aspects of overviews, and future challenges. This is the twelfth article from a collaborative methodological series of narrative reviews about biostatistics and clinical epidemiology.
Cáncer de pulmón de células no pequeñas y entrenamiento físico preoperatorio
(2023) Jofré Seguel, Fabián Andrés; Silva, Gonzalo; González, Valeria V.; Cortés-Jofré, Marcela; Ortiz Muñoz, Luis Eugenio
Celecoxib para la artritis reumatoide. Resumen SUPPORT de una revisión sistemática Cochrane
(Cochrane: Effective Practice and Organisation of Care, 2022) Morales Sepúlveda, Gabriel Francisco; Sepúlveda Basso, Juan Pablo; Bouldres, Faviana; Ortiz Muñoz, Luis Eugenio; Cortes Jofré, Marcela
La artritis reumatoide es una enfermedad autoinmune sistémica que se caracteriza por inflamación amplia y persistente del revestimiento sinovial de las articulaciones y de las vainas de los tendones. Actualmente,la Artritis reumatoide es incurable y los tratamientos se centran en el control de los síntomas como el dolor, la rigidez y la movilidad, con la intención de lograr una remisión estable y mejorar la movilidad. El celecoxib es un fármaco antiinflamatorio no esteroideo(AINE) selectivo utilizado para el tratamiento de los pacientes con artritis reumatoide.
Efectos de los enfoques alimentarios para detener la hipertensión (DASH) en pacientes embarazadas con Diabetes gestacional
(2023) Fernández Reyes, Franco Aramis; Fuentealba Sáez, Valentina; Peña Necuñir, Savka Ornella; Ortiz Muñoz, Luis Eugenio; Cortés-Jofré, Marcela
OBJETIVO: El objetivo de este análisis es entregar una descripción del cuerpo de evidencia que responde a la pregunta de interés, desde la información encontrada en revisiones sistemáticas y de los estudios primarios incluidos en ellas. La pregunta es ¿Cómo influye la dieta DASH en la prevención, progresión y manejo de la diabetes mellitus gestacional? MATERIAL Y MÉTODOS: Se realizó una búsqueda de evidencia proveniente de revisiones sistemáticas sobre los efectos de la dieta DASH en pacientes embarazadas con diabetes mellitus gestacional. Se evaluó la confianza en los resultados de cada revisión bajo la herramienta AMSTAR-2 y luego con parámetros definidos, se seleccionó la revisión que mejor responde a la pregunta y desde esta se entrega una descripción detallada de los hallazgos RESULTADOS: Se analizó críticamente los artículos “Different types of dietary advice for women with gestational diabetes mellitus”, “Associations of Diet and Physical Activity with Risk for Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis”, “Can physical activity and dietary interventions improve maternal and fetal outcomes in women with gestational diabetes mellitus? A systematic review and meta-analysis” CONCLUSIÓN: Existe evidencia que demuestra que la terapia combinada, es decir, la dieta y actividad física disminuye el riesgo de padecer diabetes mellitus gestacional. La inclusión de la dieta dash ayudó a disminuir el peso de los recién nacidos y también el número de cesáreas realizadas. Sin embargo, es necesaria la realización de más estudios que pongan en manifiesto los efectos de la terapia a largo plazo y su sostenibilidad.
Eficacia de la fisioterapia en pacientes con lesión del manguito rotador
(2023) Martínez Campos, Isidora Fernanda; Durán, Bárbara; Soubelet Espinoza, María Ignacia; Ortiz Muñoz, Luis Eugenio; Cortés-Jofré, Marcela; Sepúlveda Uribe, Sergio
OBJETIVO: El objetivo de este análisis es entregar una descripción del cuerpo de evidencia que responde a la pregunta de interés, desde la información encontrada en revisiones sistemáticas y de los estudios primarios incluidos en ellas. La pregunta es la efectividad de la fisioterapia en el tratamiento de lesiones inflamatorias del manguito rotador frente a otras intervenciones. MATERIAL Y MÉTODOS: Se realizó una búsqueda de evidencia proveniente de revisiones sistemáticas sobre la eficacia de la fisioterapia en lesiones del manguito rotador y su preferencia como intervención ante otras alternativas. Se evaluó la confianza en los resultados de cada revisión bajo la herramienta AMSTAR-2 y luego con parámetros definidos, se seleccionó la revisión que mejor responde a la pregunta y desde esta se entrega una descripción detallada de los hallazgos RESULTADOS: Se analizó críticamente el artículo “Surgery or conservative treatment for rotator cuff tear: a meta-analysis.”,”Role of extracorporeal shockwave therapy in patients with rotator cuff tendinopathy: synthetic analysis of last two decades.” y “Effectiveness of platelet-rich plasma injection in rotator cuff tendinopathy: A systematic review and Meta-Analysis of Randomized Controlled Trials”. CONCLUSIÓN: Existe evidencia para decir que la fisioterapia cumple de manera exitosa su objetivo con respecto a la optimización del movimiento y eliminación del dolor, como tratamiento convencional, gracias a ejercicios de rehabilitación, inyecciones de plasma rico en plaquetas o terapia de ondas de choque extracorpóreas, sin embargo, aún no es posible determinar que el tratamiento conservador resulta más beneficioso que otros tratamientos, como la cirugía, debido a la falta de evidencia y estudios.
Ejercicio para la dismenorrea. Un resumen SUPPORT de una revisión sistemática Cochrane. Abril 2022
(2022) Cruces-Herrera, Ana Paula; González, Agustín; Rioseco Sepúlveda, Isaías Alberto; Ortiz Muñoz, Luis Eugenio; Cortés-Jofré, Marcela
El ejercicio tiene varios beneficios para la salud y se ha recomendado como tratamiento para la dismenorrea primaria (dolor menstrual), aunque la evidencia de su efectividad en la dismenorrea primaria no está clara. Esta revisión analizó la evidencia disponible a favor de la práctica de ejercicio como tratamiento para la dismenorrea primaria.
Hallazgos histopatológicos pulmonares asociados a COVID-19: Una revisión sistemática y metaanálisis
(2023) Rodríguez Funes, María Virginia; Herrera Huezo, Héctor A.; Ortiz Segura, Andrea; Osorio, Cecilia Belem; Molina González, Dennys; Reina Meléndez, Verónica; Vindell González, Juan José; Ortiz Muñoz, Luis Eugenio; Rada Giacaman, Gabriel Alejandro
Introducción. La COVID-19 es una nueva enfermedad que requería resultados prontos provenientes de la investigación. Un abordaje para la comprensión de su fisiopatología es conocer el daño a nivel histopatológico que genera en los pulmones de los afectados. Objetivo. Proveer un resumen riguroso de la evidencia disponible sobre los hallazgos histopatológicos pulmonares en pacientes con COVID-19. Metodología. Se desarrolló una revisión sistemática con metaanálisis de proporciones. Se incluyeron estudios primarios de cualquier diseño que tuvieran datos primarios de hallazgos histopatológicos de pulmones en pacientes COVID-19. Se excluyeron revisiones y guías. Las fuentes de información fueron el repositorio centralizado Living OVerview of Evidence, PubMed/Medline, LitCovid, la base de datos COVID-19 de la Organización Mundial de la Salud, y medRxiv hasta el 3 de abril 2021. La evaluación del riesgo de sesgos se realizó utilizando las herramientas del Instituto Joanna Briggs para series de casos y reportes de casos. Se extrajo cada dato de hallazgo pulmonar histopatológico. Se calcularon las frecuencias encontradas y los datos de los hallazgos más frecuentes fueron resumidas en metaanálisis usando el método de efectos aleatorios de Der Simmonian-Liard. Se midió la heterogeneidad. Resultados. Los criterios de inclusión fueron cumplidos por 69 artículos sumando 594 sujetos. Presentaron bajo riesgo de sesgos 35 artículos. El metaanálisis de proporciones mostro daño alveolar difuso en 0,62 (IC 95 % 0,51-0,72), I2 59 % (p < 0,01), en su fase temprana (85,14 %). Conclusión. El daño alveolar difuso temprano fue el hallazgo histopatológico más frecuente en muestras pulmonares de pacientes con COVID-19.
High-flow nasal cannula in adults with chronic respiratory diseases during physical exercise: a systematic review and meta-analysis
(2024) Moya Gallardo, Eduardo Sebastián; Fajardo Gutiérrez, Jeniffer; Acevedo Encalada, Karol Stefanie; Verdugo-Paiva, Francisca; Bravo Jeria, Rocío Paz; Ortiz Muñoz, Luis Eugenio; Contreras Briceño, Felipe; Espinosa Ramírez, Maximiliano Andrés
Background: Chronic respiratory diseases (CRDs) affect at least 545 million people globally, leading to symptoms such as dyspnoea, fatigue and limited physical activity. Pulmonary rehabilitation (PR) programmes aim to improve the exercise capacity and quality of life of patients with CRD through exercise training. High-flow nasal cannula (HFNC) therapy shows potential as an adjunct treatment during exercise, but its effects on CRD populations are unclear. The purpose of this systematic review was to evaluate the effects of HFNC during exercise in people with CRD.Methods: A systematic review was conducted and eight databases and other resources were searched from inception (28 June 2022) to 4 April 2023. Studies that used adult patients with CRD and randomised controlled trial that compared the effect of HFNC versus standard care (conventional oxygen therapy or room air) during exercise were included. Two authors independently selected trials, extracted the data, assessed risks of bias and employed the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach to judging the certainty of evidence. We pooled trials using random-effect models and inverse variance estimation.Results: Seventeen studies (n=8406) were included in the review (570 patients). The evidence suggests that HFNC increases exercise time after multiple training sessions (weighted mean difference (WMD)=160.58 s; 95% 95% CI=67.32-253.83, 2 studies) and increase after a single session (WMD=72.10 s; 95% CI=28.95-115.24, 11 studies). HFNC may result in little improvements in secondary outcomes (quality of life, dyspnoea, comfort, complications and adherence).Discussion: The evidence suggests that HFNC may increase functional exercise capacity and positively enhance secondary outcomes. Continued research is justified to elucidate the role of HFNC in PR during exercise training.
Intervenciones de cambio de comportamiento para la reducción del consumo de alcohol durante el embarazo.
(2021) Ortiz Muñoz, Luis Eugenio; Parada Daza, Alejandra Cristina; Fredes González, Carolina Paz; Rojas Sobarzo, Loreto Ester; Duarte Anselmi, Giuliano; Suelves, Josep M.; Armayones Ruiz, Manuel
Introducción: a nivel mundial, se estima que más del 20% de las mujeres embarazadas consumen alcohol. La investigación actual sugiere que la ingesta de alcohol durante el embarazo pone en riesgo al recién nacido de sufrir discapacidades cognitivas y del desarrollo graves de por vida. Las intervenciones de cambio de comportamiento pueden ayudar a las mujeres a reducir su consumo de alcohol durante el embarazo. El objetivo de este análisis crítico es comprobar la validez y aplicabilidad de los resultados con respecto a la efectividad de intervenciones de cambio de comportamiento para reducir el consumo de alcohol en mujeres embarazadas, y responder a la interrogante: ¿Son efectivas las intervenciones de cambio de comportamiento en la reducción del consumo de alcohol en mujeres embarazadas?. Métodos: Se realizó una búsqueda de evidencia proveniente de revisiones sistemáticas, sobre Intervenciones de cambio de comportamiento para la reducción del consumo de alcohol durante el embarazo. Se especificó para cada revisión los componentes "pico" de la pregunta y, del listado de revisiones relevantes, se seleccionó la que pudiese responder mejor a la pregunta. Resultados: Identificamos seis revisiones sistemáticas y dos revisiones panorámicas. Se analizó críticamente el artículo “Identifying effective behavior change techniques for alcohol and illicit substance use during pregnancy: a systematic review.” Conclusión: existe evidencia para decir que algunas técnicas de cambio de comportamiento podrían ser útiles para lograr la reducción del consumo de alcohol durante el embarazo. Sin embargo, estos resultados se deben tomar con precaución dado algunas limitaciones metodológicas en la evidencia disponible.
Introduction to network meta-analysis for evidence synthesis
(2021) Gonzalez Xuriguera, Catalina Gracia; Vergara Merino, Laura; Garegnani, Luis; Ortiz Muñoz, Luis Eugenio; Meza, Nicolás
This article belongs to a collaborative methodological series of narrative reviews about biostatistics and clinical epidemiology. The goal is to present basics concepts concerning the systematics reviews of multiple treatments comparisons with network meta-analysis. For clinical questions with several therapeutic alternatives to be compared, the central question is how to classify or rank their effectiveness (benefit and harm) to choose the best option. The network meta-analysis aims to answer questions related to the effectiveness and safety of comparing multiple treatments by the simultaneous analysis of results raised from direct and indirect comparisons. The network geometry is the general graphical representation of the network meta-analysis and allows to understand and assess the strength of comparisons. The network meta-analysis should check several assumptions to be valid, especially the transitivity assumption, which allows assuming that there are no systematic differences among the included comparisons, except their compared interventions. Thus, it is possible to know the relative therapeutic effectiveness of each pair of interventions included in the network meta-analysis and their ranking in terms of categorization. It has been proposed to use a modified Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach considering the distinctive features of network meta-analysis to assess the certainty of the evidence for each comparison and the ranking of interventions.
Maternal and perinatal outcomes related to COVID-19 and pregnancy: An overview of systematic reviews
(2021) Vergara-Merino, Laura; Meza, Nicolás; Couve-Pérez, Constanza; Carrasco, Cynthia; Ortiz Muñoz, Luis Eugenio; Madrid, Eva; Bohorquez-Blanco, Sandra; Bracchiglione, Javier
Introduction: Evidence about coronavirus disease 2019 (COVID-19) and pregnancy has rapidly increased since December 2019, making it difficult to make rigorous evidence-based decisions. The objective of this overview of systematic reviews is to conduct a comprehensive analysis of the current evidence on prognosis of COVID-19 in pregnant women. Material and methods: We used the Living OVerview of Evidence (L·OVE) platform for COVID-19, which continually retrieves studies from 46 data sources (including PubMed/MEDLINE, Embase, other electronic databases, clinical trials registries, and preprint repositories, among other sources relevant to COVID-19), mapping them into PICO (population, intervention, control, and outcomes) questions. The search covered the period from the inception date of each database to 13 September 2020. We included systematic reviews assessing outcomes of pregnant women with COVID-19 and/or their newborns. Two authors independently screened the titles and abstracts, assessed full texts to select the studies that met the inclusion criteria, extracted data, and appraised the risk of bias of each included systematic review. We measured the overlap of primary studies included among the selected systematic reviews by building a matrix of evidence, calculating the corrected covered area, and assessing the level of overlap for every pair of systematic reviews. Results: Our search yielded 1132 references. 52 systematic reviews met inclusion criteria and were included in this overview. Only one review had a low risk of bias, three had an unclear risk of bias, and 48 had a high risk of bias. Most of the included reviews were highly overlapped among each other. In the included reviews, rates of maternal death varied from 0% to 11.1%, admission to intensive care from 2.1% to 28.5%, preterm deliveries before 37 weeks from 14.3% to 61.2%, and cesarean delivery from 48.3% to 100%. Regarding neonatal outcomes, neonatal death varied from 0% to 11.7% and the estimated infection status of the newborn varied between 0% and 11.5%. Conclusions: Only one of 52 systematic reviews had a low risk of bias. Results were heterogeneous and the overlap of primary studies was frequently very high between pairs of systematic reviews. High-quality evidence syntheses of comparative studies are needed to guide future clinical decisions.
Nudges as behavior change interventions to improve health and well-being. Protocol for a scoping review
(2021) Giuliano Duarte, Giuliano; Ortiz Muñoz, Luis Eugenio; Figueroa, Oriana; Laroze, Denise
Our objective is to map and summarize the evidence on nudges that assess behavior change interventions to improve health and well-being. Design: this is the protocol for a scoping reviewData source: a comprehensive search will be conducted on Cochrane database of systematic reviews (CDSR); Database of Abstracts of Reviews of Effectiveness (DARE); HTA Database; PubMed; LILACS; CINAHL; PsyclNFO; EMBASE; EPPI-Centre Evidence Library; WHO institutional Repository for information Sharing; NICE public health guidelines and systematic reviews; through an advanced search in the Epistemonikos platform. The search will cover the period until the day before this protocol is submitted to a journal. Eligibility criteria for study selection and methods Only systematic reviews (SR) will be included, which are operationally defined as any secondary research that includes only primary clinical studies, with the above search strategy applied in at least two databases that have assessed the use of nudges related to health, including SR of broader scope.Primary studies, clinical practice guides, abstracts and other evidence summary designs will be excluded. The electronic search results will be added according to the inclusion criteria. This manuscript will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR).
Nudges as Behavior Change Interventions to Improve Health and Well-Being. Protocol for a scoping review (JMIR Preprint)
(JMIR Publications, 2021) Duarte Anselmi, Giuliano; Ortiz Muñoz, Luis Eugenio; Figueroa, Oriana; Laroze, Denise
Our objective is to map and summarize the evidence on nudges that assess behavior change interventions to improve health and well-being. Design: This is the protocol for a scoping review. Data source: a comprehensive search will be conducted on Cochrane database of systematic reviews (CDSR); Database of Abstracts of Reviews of Effectiveness (DARE); HTA Database; PubMed; LILACS; CINAHL; PsyclNFO; EMBASE; EPPI-Centre Evidence Library; WHO institutional Repository for information Sharing; NICE public health guidelines and systematic reviews; through an advanced search in the Epistemonikos platform. The search will cover the period until the day before this protocol is submitted to a journal. Eligibility criteria for study selection and methods. Only systematic reviews (SR) will be included, which are operationally defined as any secondary research that includes only primary clinical studies, with the above search strategy applied in at least two databases that have assessed the use of nudges related to health, including SR of broader scope. Primary studies, clinical practice guides, abstracts and other evidence summary designs will be excluded. The electronic search results will be added according to the inclusion criteria. This manuscript will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR).
Offloader knee braces for knee osteoarthritis
(2021) Moller Macherone, Francesca Andrea; Ortiz Muñoz, Luis Eugenio; Irarrázaval Domínguez, Sebastián
INTRODUCTION Knee osteoarthritis is a relevant health problem given its high prevalence and associated disability. Within the non-pharmacological management alternatives, the use of offloader knee braces has been proposed, however, there is no consensus in the literature regarding its indication. METHODS We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS We identified 14 systematic reviews including nine studies overall, all of which were randomized trials. We conclude that the use of offloader knee braces in patients with knee osteoarthritis probably increases physical function through walking distance. However, its use may make little or no difference to physical function measured with the Hospital for Special Surgery Knee score, it may slightly worsen the quality of life and increase adverse events, but the certainty of the evidence is low. In addition, we are uncertain whether the use of offloader knee braces reduces pain as the certainty of the evidence has been assessed as very low.
Overweight and obesity as potential prognostic factors for severity and mortality in patients with COVID-19: A living systematic review protocol
(2020) Bonilla-Untiveros, Catherine; Camacho-López, Saby; Baladia, Eduard; Ortiz Muñoz, Luis Eugenio; Rada Giacaman, Gabriel Alejandro
This living systematic review aims to provide a timely, rigorous and continuously updated summary about the impact of overweight or obesity as a prognostic factor for severity and mortality in patients with COVID-19. Design This is a protocol of a living systematic review. Data sources We will conduct searches in MEDLINE/PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralized repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We will include all primary studies that assess patients with confirmed or suspected infection with SARS-CoV-2 and inform the relation of overweight or obesity with death or disease severity. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will pool the results using meta-analysis and will apply the GRADE system to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it every time the conclusions change or whenever there are substantial updates.
Prognosis of COVID-19 in pregnancy: Protocol for an overview of systematic reviews
(2020) Vergara-Merino, Laura; Pérez-Bracchiglione, Javier; Meza, Nicolás; Constanza, Couve; Carrasco, Cynthia; Ortiz Muñoz, Luis Eugenio; Rada G., Gabriel
Objective: We aim to map and summarise the current evidence about COVID-19 prognosis in pregnant women. Design: This is the protocol of an overview of systematic reviews. Data sources: We will conduct comprehensive searches in PubMed/MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO evidence questions from Epistemonikos database. In response to the COVID-19 emergency, L·OVE was adapted to expand its COVID-19 repository evidence as a way to gather it in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods: We adapted an already published common protocol for multiple parallel systematic reviews and overviews of systematic reviews to the specificities of this question. We will include all systematic reviews about COVID-19 in pregnant women. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. Ethics and dissemination: No ethics approval is considered necessary. The results of this overview will be widely disseminated via peer-reviewed publications, social networks and traditional media.
Protocol of a Living systematic review: gloves for the prevention of COVID-19 in healthy population
(2020) Ortiz Muñoz, Luis Eugenio; Duarte, Giuliano; Morales Ferrer, María Belén Elizabeth; Rada Giacaman, Gabriel Alejandro; Epistemonikos Foundation
Objective: To determine the efficacy of the use of gloves in the prevention of COVID-19 disease in healthy population. Design: This is the protocol of a living systematic review. Data sources: We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralised repository in L·OVE (Living OVerview of Evidence).L·OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In responseto the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomized trials evaluating the effect of use of gloves in healthy population to prevent COVID-19 disease. Randomised trials evaluating the effect of use of gloves during outbreaks caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates.

Browsing by Author "Ortiz Muñoz, Luis Eugenio"

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