Browsing by Author "Morales Ferrer, María Belén Elizabeth"

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    Gloves for COVID-19: A living systematic review
    (2021) Morales Ferrer, María Belén Elizabeth; Ortiz Muñoz Luis Eugenio; Duarte, Giuliano; Riquelme-Uribe, Daniel; Rada Giacaman, Gabriel Alejandro
    Methods: we adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We searched for studies evaluating the effect of glove use in healthy population to prevent COVID-19. We conducted searches using the special L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that maps PICO questions to a repository, maintained through regular searches in electronic databases, preprint servers, trial registries and websites relevant to COVID-19. All the searches covered the period until November 30, 2020. No date or language restrictions were applied.Two reviewers independently evaluated potentially eligible studies according to predefined selection criteria, and extracted data on study characteristics, methods, outcomes, and risk of bias, using a predesigned, standardised form.A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it every time the conclusions change or whenever there are substantial updates. Results Our search strategy yielded 362 references. Finally, only 1 non-randomised study evaluating the use of gloves among other preventive measures was considered eligible. We were not able to perform a meta-analyses, thus the results were presented as a narrative synthesis.In healthy population, the evidence is very uncertain about the effect of the use of gloves on COVID-19 cases, hospitalizations for COVID-19, respiratory failure and all cause-mortality. Conclusions The evidence is insufficient to support or refute the use of gloves in healthy population to prevent COVID-19. There should appear well designed studies addressing the question of this review to provide valuable evidence to inform researchers and decision makers in the near future.
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    Protocol of a Living systematic review: gloves for the prevention of COVID-19 in healthy population
    (2020) Ortiz Muñoz, Luis Eugenio; Duarte, Giuliano; Morales Ferrer, María Belén Elizabeth; Rada Giacaman, Gabriel Alejandro; Epistemonikos Foundation
    Objective: To determine the efficacy of the use of gloves in the prevention of COVID-19 disease in healthy population. Design: This is the protocol of a living systematic review. Data sources: We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralised repository in L·OVE (Living OVerview of Evidence).L·OVE is a platform that maps PICO questions to evidence from Epistemonikos database. In responseto the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customised to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods We adapted an already published common protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomized trials evaluating the effect of use of gloves in healthy population to prevent COVID-19 disease. Randomised trials evaluating the effect of use of gloves during outbreaks caused by other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomised studies in COVID-19 will be searched in case no direct evidence from randomised trials is found, or if the direct evidence provides low- or very low-certainty for critical outcomes. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit it if the conclusions change or there are substantial updates.
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    Sexual transmission of SARS-CoV-2 virus and its role in the spread of COVID-19: A living systematic review protocolSexual transmission of SARS-CoV-2 virus and its role in the spread of COVID-19: A living systematic review protocol
    (2020) Duarte, Giuliano; Ortiz Muñoz, Luis Eugenio; Morales Ferrer, María Belén Elizabeth; Acuña, María Paz; Rada Giacaman, Gabriel Alejandro
    Objective: To provide a review of the literature on the presence of SARS-CoV-2 in the sexual fluids of patients with COVID-19 and to observe its possible sexual transmission in a timely, rigorous, and continuously updated manner. Data sources: We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and a centralized repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from the Epistemonikos database. In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it covers and customized to group all COVID-19 evidence in one place. The search will cover the period until the day before submission to a journal. Eligibility criteria for selecting studies and methods: We adapted an already published standard protocol for multiple parallel systematic reviews to the specificities of this question. We will include randomized trials evaluating the sexual transmission of the SARS-CoV-2 virus. Randomized trials evaluating the sexual transmission of other coronaviruses, such as MERS-CoV and SARS-CoV, and non-randomized studies in COVID-19 will be searched if no direct evidence from randomized trials is found or if the direct evidence provides a low to a very low level of certainty for critical outcomes. Two reviewers will independently screen each study for eligibility, extract data, and assess the risk of bias. We will perform random-effects meta-analyses and use GRADE to assess the certainty of the evidence for each outcome. A living, web-based version of this review will be openly available during the COVID-19 pandemic. We will resubmit the review if the conclusions change or if there are substantial updates. PROSPERO Registration: (CRD42020189368).Objetivo: Proporcionar una revisión de la literatura sobre la presencia de SARS-CoV-2 en los fluidos sexuales de pacientes con COVID-19 y su posible transmisión sexual de manera oportuna, rigurosa y continuamente actualizada. Fuentes de datos: Realizaremos búsquedas en PubMed / Medline, Embase, Registro Cochrane Central de Ensayos Controlados (CENTRAL), literatura gris y en un repositorio centralizado en L · OVE (Living OVerview of Evidence). L · OVE es una plataforma que mapea las preguntas PICO a la evidencia de la base de datos Epistemonikos. En respuesta a la emergencia de COVID-19, L · OVE se adaptó para ampliar el rango de evidencia que cubre y se personalizó para agrupar todas las pruebas de COVID-19 en un solo lugar. La búsqueda cubrirá el período hasta el día anterior al envío a una revista. Criterios de elegibilidad para la selección de estudios y métodos: Adaptamos un protocolo común ya publicado para múltiples revisiones sistemáticas paralelas a las especificidades de esta pregunta. Incluiremos ensayos aleatorios que evalúen la transmisión sexual del virus SARS-CoV-2. Se buscarán ensayos aleatorizados que evalúen la transmisión sexual de otros coronavirus, como MERS-CoV y SARS-CoV, y estudios no aleatorizados en COVID-19 en caso de que no se encuentre evidencia directa de ensayos aleatorizados, o si la evidencia directa proporciona una - o certeza muy baja para resultados críticos. Dos revisores evaluarán de forma independiente la elegibilidad de cada estudio, extraerán datos y evaluarán el riesgo de sesgo. Realizaremos metanálisis de efectos aleatorios y utilizaremos GRADE para evaluar la certeza de la evidencia para cada resultado. Una versión viva basada en la web de esta revisión estará disponible abiertamente durante la pandemia de COVID-19. Lo volveremos a enviar si las conclusiones cambian o hay actualizaciones sustanciales. Registro PROSPERO: (CRD42020189368).