Browsing by Author "Massardo, Teresa"

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    Daño vascular asociado a uso de cocaína. Caso clínico
    (SOC MEDICA SANTIAGO, 2012) Massardo, Teresa; Pino, Angela; Berrocal, Isabel; Castro, Gabriel; Prat, Hernan; Pereira, Jaime
    Cocaine abuse is associated with an increased risk of cardiac and cerebro vascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood although intravascular thrombus formation and accelerated atherosclerosis are prominent findings. We report a 39-year-old male addicted to cocaine, who presented with three consecutive ischemic events characterized by an acute myocardial infarction and two ischemic strokes complicated by cardiac failure and severe neurological sequelae. The pathophysiology of cocaine-induce vascular damage and the management of the ischemic complications are discussed. (Rev Med Chile 2012; 140: 507-511).
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    Descripción de los hallazgos en el perfil lipídico y proteico de pacientes dependientes a cocaína, en abstinencia reciente
    (2015) Massardo, Teresa; Araya A., Verónica; Ibáñez, Carlos; Véliz, Jonathan; Fernández, René; Jaimovich, Rodrigo; Pallavicini, Julio; Chandía, Rolando; Pereira, Karla; Pereira Garcés, Jaime Ignacio
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    Identification of Statin’s Action in a Small Cohort of Patients with Major Depression
    (2021) Thakkar, Ishani; Massardo, Teresa; Pereira, Jaime; Quintana, Juan Carlos; Risco, Luis; Saez, Claudia G.; Corral, Sebastián; Villa, Carolina; Spuler, Jane; Olivares, Nixa; Valenzuela, Guillermo; Castro, Gabriel; Riedel, Byron; Vicentini, Daniel; Muñoz, Diego; Lastra, Raúl; Rodriguez-Fernandez, Maria
    Statins are widely used as an effective therapy for ischemic vascular disorders and employed for primary and secondary prevention in cardiac and cerebrovascular diseases. Their hemostatic mechanism has also been shown to induce changes in cerebral blood flow that may result in neurocognitive improvement in subjects with Major Depressive Disorder. Behavioral data, various blood tests, and resting-state brain perfusion data were obtained at the start of this study and three months post-therapy from a small cohort of participants diagnosed with Major Depressive Disorder. Subjects received either rosuvastatin (10 mg) or placebo with their standard selective serotonin reuptake inhibitors therapy. At the end of the study, patients using rosuvastatin reported more positive mood changes than placebo users. However, standard statistical tests revealed no significant differences in any non-behavioral variables before and after the study. In contrast, feature selection techniques allowed identifying a small set of variables that may be affected by statin use and contribute to mood improvement. Classification models built to assess the distinguishability between the two groups showed an accuracy higher than 85% using only five selected features: two peripheral platelet activation markers, perfusion abnormality in the left inferior temporal gyrus, Attention Switching Task Reaction latency, and serum phosphorus levels. Thus, using machine learning tools, we could identify factors that may be causing self-reported mood improvement in patients due to statin use, possibly suggesting a regulatory role of statins in the pathogenesis of clinical depression.
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    Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users
    (PERGAMON-ELSEVIER SCIENCE LTD, 2011) Saez, Claudia G.; Olivares, Paulina; Pallavicini, Julio; Panes, Olga; Moreno, Natalia; Massardo, Teresa; Mezzano, Diego; Pereira, Jaime
    Background: Cocaine use has been related with the development of accelerated atherosclerosis and with an increased risk of cardiac and cerebrovascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood, although thrombus formation and altered vascular function are prominent findings.
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    Platelet activation in chronic cocaine users: Effect of short term abstinence
    (TAYLOR & FRANCIS INC, 2011) Pereira, Jaime; Saez, Claudia G.; Pallavicini, Julio; Panes, Olga; Pereira Flores, Karla; Cabreras, Manuel J.; Massardo, Teresa; Mezzano, Diego
    Cocaine abuse increases the risk of cardiac and cerebrovascular events, such as myocardial infarction and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood although intravascular thrombus formation has been observed. The aim of this study was to investigate the existence of platelet activation and the effect of short-term abstinence in chronic cocaine consumers. We studied 23 cocaine dependent individuals (aged 20-54 years) who met DSM-IV criteria for cocaine dependence and 20 controls. Samples were obtained at baseline, within 72 h of last drug exposure and after 4 weeks of controlled abstinence. Monocyte-platelet aggregates (MPA) were measured by flow cytometry. Plasma levels of soluble CD40L (sCD40L), Neutrophil-Activating Peptide-2 (NAP-2) and regulated on activation normal T cells expressed and secreted (RANTES) were determined by ELISA. Levels of MPA, sCD40L, NAP-2 and RANTES were significantly higher (all p < 0.05) in cocaine addicts compared to controls at baseline. All the parameters returned to values similar to the control group after 4-weeks' abstinence. Levels of sCD40L and RANTES were associated with an index of intensity of drug consumption (p < 0.02). Our results demonstrate that cocaine use induces platelet activation which is a prominent finding after recent consumption. The persistence over time of this condition may contribute not only to acute thrombotic complications but also to the development of early-onset atherosclerotic process observed in cocaine abusers.