Browsing by Author "Iturrieta, Pablo"
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- ItemA physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection(2020) Cruces, Pablo; Retamal Montes, Jaime; Hurtado Sepúlveda, Daniel; Erranz, Benjamín; Iturrieta, Pablo; González, Carlos; Díaz, FrancoAbstract Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
- ItemDilatation and shearing in tectono-volcanic systems from poro-elasto-plastic models set in the Southern Andes Volcanic Zone context, inferences on geofluid flow(2022) Gerbault, Muriel; Saez, Felipe; Ruz Ginouves, Javiera; Cembrano, José; Iturrieta, Pablo; Hurtado, Daniel; Hassani, Riad; Browning, JohnGeothermal fields near volcanic complexes and active crustal-scale fault zones require an understanding of the mechanical interactions that control variations in pore fluid pressure at a crustal scale. Crustal faults can trigger and modify fluid flow depending mostly on their geometry and mechanical properties. In turn, fluid flow reduces normal stresses causing either shearing or dilation through the rock mass, concomitant with hydraulic fracturing or seismic fault reactivation. The Southern Andes Volcanic Zone (SAVZ) documents widespread geofluid migration through the crust within a bulk regional transpressive regime. We address here the key role of dilatational domains potentially hosting geothermal fluids, in close relation to shear zones, by using elasto-plastic and poro-elasto-plastic models. First we define models considering Drucker-Prager elasto-plasticity, that account for either: 1) an inflating magmatic cavity or 2) a dextral slipping fault zone ca. 4 km apart, to assess the rheological conditions leading to brittle failure of the bedrock around the fault zone and the cavity, respectively. This setup is applied to the San-Pedro Tatara volcanic complex in the SAVZ. Parametric tests of Young’s moduli and frictional strength provide not only the conditions for macro-scale shear failure, but also shows the development of diffuse domains of dilatational strain in the intervening bedrock. Both void opening and/or volumetric cracking may lead to an increase in porosity and/or permeability, allowing over-pressurized geofluids to migrate within these domains. Our results (Ruz Ginouves et al., JVGR, 2021) show that generally, shallow magma chambers (~< 4 km) and fault zones must be close enough to trigger bedrock failure of the other counterpart (< 4 km), unless the magma chamber is deeper than 10 km, the magma overpressure is high or the regional strength is very low. We argue that alternating strike-slip faulting and magmatic overpressure promote a variety of stress fields that may explain observations of transient fluid pathways on seemingly independent timescales along the Andean margin. To gain further insights into these processes, we develop a numerical scheme to quantify stress and fluid flow with a coupled poro-mechanical approach implemented using Python’s Opensource FEM library FeniCS. Benchmarks are first presented to validate our poro-elasto-plastic approach. Then a synthetic setup shows how fluids get channelized around a fault zone several days after an imposed fault slip motion. Preliminary results are discussed in comparison to a high enthalpy geothermal system associated with another volcanic complex in the SAVZ.
- ItemField observations and numerical models of a Pleistocene-Holocene feeder dyke swarm associated with a fissure complex to the east of the Tatara-San Pedro-Pellado complex, Southern Volcanic Zone, Chile(2020) Ruz Ginouves, Javiera Andrea; Browning, John; Cembrano, José; Iturrieta, Pablo; Gerbault, Muriel; Sielfeld, GerdMagma is transported through the lithosphere as dykes which, during periods of unrest, may feed eruptions at the surface. The propagation path of dykes is influenced by the crustal stress field and can be disturbed by crustal heterogeneities such as contrasting rock units or faults. Moreover, as dykes propagate, they themselves influence the surrounding stress field through processes of stress transfer, crustal deformation and seismic failure. The result is the formation of arrested dykes, as well as contrasting strike and dip angles and dyke segmentation. Here, we study the mechanisms of dyke injection and the role played in modifying the stress field and potential propagation paths of later dyke injections. To do this we combine field data from an eroded and well-exposed shallow feeder dyke swarm with a suite of two-dimensional FEM numerical models. We mapped 35 dyke segments over a ~1 km long dyke swarm exposed ~5 km to the East of Pellado Volcano, in the Tatara-San Pedro-Pellado (TSPP) volcanic complex, Southern Volcanic Zone of the Andes. Detailed mapping of the swarm elucidates two preferential strike orientations, one ~N80°E and the other ~N60°E. Our numerical models simulate both the TSPP volcanic complex and the studied dyke swarm as zones of either magmatic excess pressure or as a rigid inclusion. The crustal segment hosting the volcanic complex and dykes is modelled using an elastic domain subjected to regional compression in select model cases. Model outputs provide the stress and strain fields resulting from the different geometries and applied boundary loads. The model results indicate that individual dyke injections can locally rotate the principal stresses such as to influence the range of orientations over which later dykes will form. The orientation of σ1 at the dyke tip ranges over 60° (±30° either side of the dyke tip) indicating that the strike orientation of later dykes will fall within this range. The effect of adding a bulk regional compression is to locally increase the magnitude of favorably oriented tensile stresses in the bedrock but to reduce the range of σ1 orientations to 40° (±20°). This implies that under a far-field transpressive stress regime, as is common in Andean settings, regional dyke swarms will tend to maintain their strike orientation parallel to the regional bulk stress. These results should be accounted for when studying periods of volcanic unrest in order to discern the location and orientation of potential fissure eruptions in active volcanic areas such as the Southern Volcanic Zone of the Andes.
- ItemProgression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation(2020) Hurtado Sepúlveda, Daniel; Sarabia Vallejos, Mauricio; Iturrieta, Pablo; Erranz, Benjamín; Lillo, Felipe; Morales, Felipe; Blaha, Katherine; Medina, Tania; Diaz, Franco; Cruces, PabloAbstract Background Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs without MV support, the mechanisms and evolution of lung tissue deformation remain understudied. In this work, we quantify the progression and heterogeneity of regional strain in injured lungs under spontaneous breathing and under MV. Methods Lung injury was induced by lung lavage in murine subjects, followed by 3 h of spontaneous breathing (SB-group) or 3 h of low Vt mechanical ventilation (MV-group). Micro-CT images were acquired in all subjects at the beginning and at the end of the ventilation stage following induction of lung injury. Regional strain, strain progression and strain heterogeneity were computed from image-based biomechanical analysis. Three-dimensional regional strain maps were constructed, from which a region-of-interest (ROI) analysis was performed for the regional strain, the strain progression, and the strain heterogeneity. Results After 3 h of ventilation, regional strain levels were significantly higher in 43.7% of the ROIs in the SB-group. Significant increase in regional strain was found in 1.2% of the ROIs in the MV-group. Progression of regional strain was found in 100% of the ROIs in the SB-group, whereas the MV-group displayed strain progression in 1.2% of the ROIs. Progression in regional strain heterogeneity was found in 23.4% of the ROIs in the SB-group, while the MV-group resulted in 4.7% of the ROIs showing significant changes. Deformation progression is concurrent with an increase of non-aerated compartment in SB-group (from 13.3% ± 1.6% to 37.5% ± 3.1%), being higher in ventral regions of the lung. Conclusions Spontaneous breathing in lung injury promotes regional strain and strain heterogeneity progression. In contrast, low Vt MV prevents regional strain and heterogeneity progression in injured lungs.