Browsing by Author "Hernandez, R."

Now showing 1 - 7 of 7
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    Innovations in surgical training: exploring the role of artificial intelligence and large language models (LLM)
    (2023) Varas Cohen, Julian Emanuel; Coronel, B.V.; Villagrán, I.; Escalona, G.; Hernandez, R.; Schuit, G.; Durán, V.; Lagos-Villaseca, A.; Jarry, C.; Neyem, A.; Achurra, P.
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    Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma
    (2019) Robles-Planells, C.; Michelson, S.A.; Mena, J.; Escrig, D.; Rojas, J.L.; Sanchez-Guerrero, G.; Hernandez, R.; Barrera-Avalos, C.; Rojo, L.E.; Kalergis Parra, Alexis Mikes; Sauma, D.; Imarai, M.; Fernandez, R.; Robles, C.A.; Leiva-Salcedo, E.; Santander, R.; Escobar, A.; Acuna-Castillo, C.
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    Local Knowledge for Addressing Food Insecurity: The Use of a Goat Meat Drying Technique in a Rural Famine Context in Southern Africa
    (2019) Valle Menéndez, Martín del; Ibarra Eliessetch, José Tomás; Hormann, P.A.; Hernandez, R.; Riveros Fernández, José Luis
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    Multistate Models: Accurate and Dynamic Methods to Improve Predictions of Thrombotic Risk in Patients with Cancer
    (2019) Carmona-Bayonas, A.; Jimenez-Fonseca, P.; Garrido S., Marcelo; Custodio, A.; Hernandez, R.; Lacalle, A.; Cano, J.M.; Aguado, G.; De Castro, E.M.; Mancenido, F.A.; Macias, I.; Visa, L.; Richard, M.M.; Mangas, M.; Canovas, M.S.; Longo, F.; Rey, L.I.; Lago, N.M.; Carnicero, A.M.; Sanchez, A.; Azkarate, A.; Limon, M.L.; Perez, C.H.; Ramchandani, A.; Pimentel, P.; Cerda, P.; Serrano, R.; Gil-Negrete, A.; Marin, M.; Hurtado, A.; Bayona, R.S.; Gallego, J.
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    Optimal duration of first-line chemotherapy for advanced gastric cancer: data from the AGAMENON registry
    (SPRINGER INTERNATIONAL PUBLISHING AG, 2020) Viudez, A.; Carmona Bayonas, A.; Gallego, J.; Lacalle, A.; Hernandez, R.; Cano, J. M.; Macias, I; Custodio, A.; Martinez de Castro, E.; Sanchez, A.; Iglesia, L.; Reguera, P.; Visa, L.; Azkarate, A.; Sanchez Canovas, M.; Mangas, M.; Limon, M. L.; Martinez Torron, A.; Asensio, E.; Ramchandani, A.; Martin Carnicero, A.; Hurtado, A.; Cerda, P.; Garrido, M.; Sanchez Bayonas, R.; Serrano, R.; Jimenez Fonseca, P.; AGAMENON Study Grp
    Background The optimal duration of first-line chemotherapy for patients with advanced gastric cancer is unknown. Diverse clinical trials have proposed different strategies including limited treatment, maintenance of some drugs, or treatment until progression. Method The sample comprises patients from the AGAMENON multicenter registry without progression after second evaluation of response. The objective was to explore the optimal duration of first-line chemotherapy. A frailty multi-state model was conducted. Results 415 patients were divided into three strata: discontinuation of platinum and maintenance with fluoropyrimidine until progression (30%, n = 123), complete treatment withdrawal prior to progression (52%, n = 216), and full treatment until progression (18%, n = 76). The hazard of tumor progression decreased by 19% per month with the full treatment regimen. However, we found no evidence that fluoropyrimidine maintenance (hazard ratio [HR] 1.07, confidence interval [CI] 95%, 0.69-1.65) worsened progression-free survival (PFS) with respect to treatment until progression. Predictive factors for PFS were ECOG performance status, >= 3 metastatic sites, prior tumor response, and bone metastases. Toxicity grade 3/4 was more common in those who continued the full treatment until progression vs fluoropyrimidine maintenance (16% vs 6%). Conclusion The longer duration of the full initial regimen exerted a protective effect on the patients of this registry. Platinum discontinuation followed by fluoropyrimidine maintenance yields comparable efficacy to treatment up to PD, with a lower rate of serious adverse events.
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    Second-line treatment in advanced gastric cancer : Data from the Spanish AGAMENON registry
    (2020) Sanchis, A. C.; Gallego, J.; Hernandez, R.; Arrazubi, V.; Custodio, A.; Cano, J. M.; Aguado, G.; Macias, I.; Lopez, C.; Garrido S., Marcelo; Lopez, F.; Visa, L.; Lago, N. M.; Montes, A. F.; Limon, M. L.; Azkarate, A.; Pimentel, P.; Reguera, P.; Ramchandani, A.; Cacho, J. D.; Carnicero, A. M.; Granja, M.; Richard, M. M.; Perez, C. H.; Hurtado, A.; Serra, O.; Buxo, E.; Tocino, R. V.; Jimenez-Fonseca, P.; Carmona-Bayonas, A.
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    Univalent harmonic mappings and linearly connected domains
    (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2007) Chuaqui, M.; Hernandez, R.
    We investigate the relationship between the univalence of f and of h in the decomposition f = h + (g) over bar of a serise-preserving harmonic mapping defined in the unit disk D subset of C. Among other results, we determine the holomorphic univalent maps It for which there exists c > 0 such that every harmonic mapping of the form f = h + (g) over bar with vertical bar g'vertical bar < c vertical bar h'vertical bar is univalent. The notion of a linearly connected domain appears in our study in a relevant way. (c) 2006 Elsevier Inc. All rights reserved.