Browsing by Author "Giordano Villatoro, Ady"
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- ItemBioactive compounds and antibacterial properties of monofloral Ulmo honey(2020) Velásquez, P; Montenegro Rizzardini, Gloria; Leyton, Felipe; Ascar, Loreto; Ramírez, O; Giordano Villatoro, Ady
- ItemBioactive polyphenols and antioxidant capacity of Azara petiolaris and Azara integrifolia Honeys(2018) Giordano Villatoro, Ady; Retamal, Mauricio; Leyton, Felipe; Martinez, Patricia; Bridi, Raquel; Velasquez, Patricia; Montenegro Rizzardini, Gloria
- ItemBioactivities of phenolic blend extracts from Chilean honey and bee pollen(2019) Velásquez, Patricia; Montenegro Rizzardini, Gloria; Giordano Villatoro, Ady; Retamal, M.; Valenzuela, L. M.
- ItemChemical composition and antibacterial activity of red murta (Ugni molinae Turcz.) seeds : an undervalued Chilean resource(2020) Cabrera Barjas, G.; Quezada, A.; Bernardo, Y.; Moncada, M.; Zuniga, E.; Wilkens, M.; Giordano Villatoro, Ady; Nesic, A.; Delgado, N.
- ItemDetermination of pesticides in river water using rotating disk sorptive extraction and gas chromatography-mass spectrometry(2011) Giordano Villatoro, Ady; Richter, Pablo; Ahumada, Ines
- ItemDetermination of sunscreen compounds in water samples by silicone rod extraction(2013) Giordano Villatoro, Ady; Richter, Pablo; Leiva, K.; Ascar, Loreto
- ItemDifferences between phenolic content and antioxidant capacity of quillay Chilean honeys and their separated phenolic extracts(2017) Bridi, Raquel; Nuñez-Quijada, Gabriel; Aguilar, Patricia; Martínez, Patricia; Lissi, Eduardo; Giordano Villatoro, Ady; Montenegro Rizzardini, Gloria
- ItemEstrategias de screening basadas en espectroscopía Raman para la caracterización de mieles nativas chilenas: estudio de azúcares adulterantes y pesticidas neonicotinoides(2023) Leyton Soto, Felipe Arturo; Isaacs Casanova, Mauricio; Giordano Villatoro, Ady; Pontificia Universidad Católica de Chile. Escuela de QuímicaActualmente, la búsqueda de metodologías analíticas rápidas, sencillas y económicas para la determinación de adulteración y presencia de contaminantes en matrices ambientales es fundamental. La espectroscopía Raman surge como una alternativa, ya que proporciona una huella dactilar vibracional única que permite identificar una molécula y además mediante el uso de plataformas SERS mejora la intensidad de señales características de grupos de alta densidad electrónica. En este trabajo, para determinar el contenido de azúcares adulterante en muestras de miel, se adulteraron intencionalmente muestras de miel auténtica en proporciones desde 10 a 90% con soluciones de glucosa, fructosa, sacarosa y un jarabe comercial. De esta forma, a partir de la espectroscopía Raman junto con algoritmos quimiométricos multivariados de tipo PCA, SIMCA y PLSR se determinó la autenticidad de un grupo de muestras de mieles Chilenas, además de poder clasificar y cuantificar a nivel de screening el contenido de adulterante en muestras de miel. Por otro lado, para la determinación de pesticidas se sintetizaron sustratos SERS con nanohojas de plata (AgNS) sobre una superficie de cobre, lo que produjo un fuerte efecto SERS y una intensidad de señal reproducible a partir de la molécula de sonda de azul de metileno en un tiempo de reacción óptimo de 1 min. Se realizó un análisis cuantitativo del plaguicida imidacloprid en solución variando la concentración del plaguicida, obteniendo espectros con señales características y detectando este analito a 0,02 µmol L 1, para luego realizar una extracción de QuEChERS en miel obteniendo un porcentaje de recuperación del 75%, permitiendo establecer una metodología de screening. Además, se llevaron a cabo simulaciones de la teoría funcional de la densidad para de esta forma poder realizar una asignación de los modos vibracionales del imidacloprid.
- ItemFlavonoids and triterpenes isolated from Eucryphia cordifolia (Cunoniaceae)(2022) Viteri Espinoza, Rafael Antonio; Giordano Villatoro, Ady; Montenegro Rizzardini, Gloria; Zacconi, Flavia C. M.The phytochemical study of the leaves of Eucryphia cordifolia (Cunoniaceae) allowed for the isolation of six compounds: the triterpenes betulin (1) and 28-acetoxy betulin (3), the steroid β-sitosterol (2), the flavonol quercetrin (4), the flavanonol astilbine (5) and the flavanol catechin (6). The structures of the isolated compounds were clearly assigned through 1D and 2D-NMR, MS studies, and compared to previously described data. This is the first report on the isolation of compounds 1–4 and 6 from the genus Eucryphia. The chemotaxonomic importance of the isolated compounds within the family of Cunoniaceae-related plants is discussed.
- ItemIbuprofen, Carbamazepine and β-Estradiol Determination Using Thin-Film Microextraction and Gas Chromatography-Mass Spectrometry(2016) Giordano Villatoro, Ady; Vásquez, José; Retamal, Mauricio; Ascar, Loreto
- ItemInternational Regulations of Propolis Quality : Required Assays do not Necessarily Reflect their Polyphenolic‐Related In Vitro Activities(2015) Bridi, Raquel; Montenegro Rizzardini, Gloria; Nunez-Quijada, G.; Giordano Villatoro, Ady; Moran-Romero, M.F.; Jara-Pezoa, I.; Speisky, Hernán; Atala, E.; López Alarcón, Camilo Ignacio
- ItemLC-MS/MS analysis of neonicotinoid insecticides : residue findings in chilean honeys(2018) Bridi, Raquel; Larena, Arturo; Nunez Pizarro, Paula; Giordano Villatoro, Ady; Montenegro Rizzardini, Gloria
- ItemMobility of nonsteroidal Anti-inflammatory drugs in soils with and without amendment of biosolid(2017) Ascar. L.; Ahumada, I.; Morales, N.; Garrido, T.; Giordano Villatoro, Ady; Leiva, K.
- ItemNutritional Composition and Polyphenolic Content of Edible Peumus boldus Mol. Fruits.(2017) Velasquez, P.; Sandoval, I.; Giordano Villatoro, Ady; Gomez Unjidos, Miguel Crescencio; Montenegro Rizzardini, Gloria
- ItemPharmaceutical compounds determination in water samples: Comparison between solid phase extraction and stir bar sorptive extraction(2017) Suazo, Fernanda; Vásquez, José; Retamal, Mauricio; Ascar, Loreto; Giordano Villatoro, Ady
- ItemPolyphenolic distribution in organs of Argylia radiata, an extremophile plant from Chilean Atacama desert(2020) Morales Tapia, Pablo Andrés; Cabrera Barjas, G.; Giordano Villatoro, Ady
- ItemRelation between composition, antioxidant and antibacterial activities and botanical origin of multi-floral bee pollen.(2017) Velásquez, P.; Rodríguez, K.; Retamal, M.; Giordano Villatoro, Ady; Valenzuela Roediger, Loreto Margarita; Montenegro Rizzardini, Gloria
- ItemToward the cholinesterase inhibition potential of TADDOL derivatives: Seminal biological and computational studies(2022) Constantino, Andrea R.; Charbe, Nitin Bharat; Duarte, Yorley; Gutierrez, Margarita; Giordano Villatoro, Ady; Prasher, Parteek; Dua, Kamal; Mandolesi, Sandra; Zacconi, Flavia C. M.Alzheimer's disease (AD) is a degenerative neurological disease characterized by gradual loss of cognitive skills and memory. The exact pathogenesis involved still remains unrevealed, but several studies indicate the involvement of an array of different enzymes, underlining the multifactorial character of the disease. Inhibition of these enzymes is therefore a powerful approach in the development of AD treatments, with promising candidates, including acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidase. Interestingly, AChE is the target of a major pesticide family (organophosphates), with several reports indicating an intersection between the pesticide's activity and AD. In this study, various TADDOL derivatives were synthesized and their in vitro activities as AChE/BuChE inhibitors as well as their antioxidant activities were studied. Molecular modeling studies revealed the capability of TADDOL derivatives to bind to AChE and induce inhibition, especially compounds 2b and 3c furnishing IC50 values of 36.78 +/- 8.97 and 59.23 +/- 5.31 mu M, respectively. Experimental biological activities and molecular modeling studies clearly demonstrate that TADDOL derivatives with specific stereochemistry have an interesting potential for the design of potent AChE inhibitors. The encouraging results for compounds 2b and 3c indicate them as promising scaffolds for selective and potent AChE inhibitors.
- ItemVariation of Secondary Metabolites in the Aerial Biomass of Cryptocarya alba(2019) Giordano Villatoro, Ady; Fuentes Barros, G.; Castro Saavedra, S.; González Cooper, A.; Suárez Rozas, C.; Salas Norambuena, J.; Acevedo Fuentes, W.; Leyton Soto, Felipe Arturo; Tirapegui, C.; Echeverría, J.; Claros, S.; Cassels, B. K.