Browsing by Author "Gabrielli, Luigi"
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- ItemAcute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with pulmonary artery hypertension(2017) Gabrielli, Luigi; Ocaranza, María Paz; Sitges, Marta; Kanacri, Andrés; Saavedra Madariaga, Rodrigo Alejandro; Sepúlveda, Pablo; Sepúlveda, Luis; Rossel, Víctor; Zagolin, Mónica; Verdejo Pinochet, Hugo; Baraona Reyes, Fernando Exequiel; Zalaquett Sepúlveda, Ricardo; Chiong, Mario; Lavandero, Sergio; Castro Gálvez, Pablo Federico
- ItemAngiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension(2018) Gonzalez, Leticia; Novoa, Ulises; Moya, Jackeline; Gabrielli, Luigi; Jalil Milad, Jorge; Garcia, Lorena; Chiong, Mario; Lavandero, Sergio; Paz Ocaranza, Maria
- ItemAporte de la ecocardiografía tridimensional en el diagnóstico y manejo de la endocarditis infecciosa. Experiencia clínica(2017) Vega, Julián; Gabrielli, Luigi; Cordova, Samuel; Muñoz Contreras, María Cecilia; Mc-Nab Martin, Paul Andrew; Saavedra Madariaga, Rodrigo Alejandro; Zalaquett Sepúlveda, Ricardo
- ItemAsociación entre strain y strain rate auricular izquierdo evaluado por speckle tracking y fibrilación auricular post cirugía de revascularización miocárdica(2011) Gabrielli, Luigi; Córdova, S.; Enríquez, A.; Mc-Nab Martin, Paul Andrew; Verdejo Pinochet, Hugo; Godoy, I.; Corbalán Herreros, RamónIntroducción: La fibrilación auricular (FA) es la arritmia más común post cirugía de revascularización miocárdica (CRM) y está asociada a dilatación y disfunción auricular izquierda (AI). El strain y strain rate global longitudinal AI determinado por speckle tracking constituyen herramientas novedosas en la evaluación de la función AI. Objetivo: evaluar el strain y strain rate global longitudinal AI en pacientes con enfermedad coronaria con indicación de CRM y su relación con el desarrollo de FA post operatoria. Métodos: se incluyeron pacientes consecutivos con indicación de CRM, en ritmo sinusal con fracción de eyección > 50%. Se registraron características clínicas y ecocardiográficas con evaluación del strain AI: onda s (LASs) y strain rate: onda a (LASRa), onda s (LASRs) por speckle tracking (pre-cirugía). Se evaluó la ocurrencia de FA en el período post operatorio (una semana) mediante monitorización electrocardiografía continua. Se utilizó t-Student, chi-cuadrado y regresión logística múltiple. Resultados: Se incluyeron 70 pacientes, 26% presentaron FA. LASs, LASRr y LASRa estaban significativamente disminuidos en los pacientes que desarrollaron FA post CRM, LASs (10 ± 1,1 vs 24 ± 1,2%, p < 0,001), LASRa (- 0,6 ± 0,1 vs - 1,8 ± 0,12, p < 0,001) LASRs (0,6 ± 0,007 vs 1,2 ± 0,008, p < 0,001). Los pre-dictores independientes de FA fueron: LASRs OR: 6,1 IC 95% (1,3-15,2); LASRa OR: 2,4 IC 95% (1,1-19,6); volumen AI OR: 4,67 IC 95% (1,5-19,2) y edad > 65 años OR: 2,31 IC 95% (1,1-15,8). Conclusiones: LASs, LASRs y LASRa están disminudos en pacientes que desarrollan FA post CRM y LASRs, LASRa fueron predictores independientes de ésta.
- ItemAssessment of Left Atrial Function in Hypertrophic Cardiomyopathy and Athlete's Heart: A Left Atrial Myocardial Deformation Study(2012) Gabrielli, Luigi; Enríquez, Andrés; Córdova Alvestegui, Samuel Edmundo; Yáñez, Fernando; Godoy J., Iván; Corbalán Herreros, Ramón
- ItemAtrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients(2016) Castro Gálvez, Pablo Federico; Lavandero, S.; Gabrielli, Luigi; Corbalán Herreros, Ramón; Verdejo Pinochet, Hugo; Becerra, E.; Zalaquett Sepúlveda, Ricardo; Del Campo, Andrea; Garcia, L.; Troncoso Pino, Rodrigo; Chiong, M.; Marin, A.
- ItemAtrial functional and geometrical remodeling in highly trained male athletes: for better or worse?(2014) Gabrielli, Luigi; Bijnens, B.; Butakoff, C.; Duchateau, N.; Montserrat, S.; Merino, B.; Gutiérrez, J.; Pare, C.; Mont, Lluis; Brugada, Josép; Sitges, Marta
- ItemBig thrombus "sitting" in an atrial septal aneurysm(2017) Vega, Julián; Gabrielli, Luigi; Cordova, Samuel; Saavedra Madariaga, Rodrigo Alejandro; Mc-Nab Martin, Paul Andrew
- ItemCambios agudos en la función auricular derecha post uso de iloprost inhalatorio en pacientes con hipertensión arterial pulmonar : estudio con técnicas de deformación de imagen(2015) Kanacri, Andres; Gabrielli, Luigi; Vega, Julián; Saavedra Madariaga, Rodrigo Alejandro; Cordova, Samuel; Sepulveda, Pablo; Castro Gálvez, Pablo Federico
- ItemCambios en el pronóstico a largo plazo de la hipertensión arterial pulmonar(SOC MEDICA SANTIAGO, 2011) Enriquez, Andres; Castro, Pablo; Sepulveda, Pablo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Ferrada, Marcela; Lapostol, CarolinaBackground: Pulmonary artery hypertension (PAR) is a progressive disease with high mortality. Major advances had been made in the treatment of this condition during the last decade. Aim: To characterize the clinical evolution and mortality of a cohort of Chilean patients. Material and Methods: Seventeen patients with PAH diagnosed in the last 10 years in two Chilean hospitals were enrolled. Measurements at diagnosis included hemodynamic variables and 6-minute walk test. The patients were followed clinically for 3 years and the observed mortality was compared with that predicted by the prognostic equation proposed by the historic registry of the National Institutes of Health (NIH). Results: The mean age of patients was 45 years and 80% had an idiopathic PAH. The mean median pulmonary artery pressure was 57 +/- 15 mmHg, the cardiac index was 2.4 +/- 0.7 l/min/m(2) and the right atrial pressure was 12 +/- 8 mmHg. The 6-minute walk distance was 348 +/- 98 m. All patients received anticoagulants. Eighty two percent received ambrisentan, 12% received bosentan, 29% received iloprost and 24% sildenafil. At the end of follow-up only 3 patients had died, with an observed survival rate of 88, 82 and 82% at 1, 2 and 3 years, respectively. In contrast, the survival calculated according to the predictive formula of the NIH was 67, 56 and 45%, respectively. Among surviving patients, an improvement in exercise capacity was observed after one year (p < 0.05). Conclusions: The observed survival rate was significantly better than that estimated according to historical data. Furthermore, therapy was associated with an improvement in functional capacity after one year. This prognostic improvement is consistent with data of other contemporary registries published after the NIH Registry. (Rev Med Chile 2011; 139: 327-333).
- ItemCardiac dyssynchrony correlates with left ventricular remodeling after myocardial infarction(SOC MEDICA SANTIAGO, 2009) McNab, Paul; Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo; Carlos Quintana, Juan; Rodriguez, Jose A.; Corbalan, RamonBackground: Cardiac dyssynchrony is common in advanced heart failure (HF), but the changes in cardiac synchrony after myocardial infarction (MI) have not been adequately described. Aim: To study the relationship between cardiac synchrony and left ventricular remodeling after acute myocardial infarction. Material and methods: Forty nine patients aged 59+/-10 years (77% men) with a first episode of a ST segment elevation MI were studied. Scintigraphic left ventricular function and synchrony analyses were performed at baseline and after a six months follow-up. Determinations were compared with 33 healthy subjects. Results: At baseline, patients with MI had a decreased left ventricular ejection fraction (LVEF) and significant dyssynchrony, when compared with controls. LVEF was 36.4%+/-10%, left ventricular end-diastolic volume (LVEDV) 127+/-38 mL, interventricular delay (IEV) 29+/-35 milliseconds (ms), and intraventricular delay (IAV), 234+/-89 ms. After 6 months, LVEF significantly improved (38%+/-10%, p = 0.042) without significant changes in LVEDV (129+/-32 mL, p = 0.97), IEV (24+/-17, p = 0.96) or IAV (231 +/- 97, p = 0.34). At baseline there were significant correlations between IAV and LVEF, and between IAV and LVEDV (r = -0.48, p = 0.001 and r = -0.41, p = 0.004, respectively). These correlations remained significant after 6 months. There was a positive correlation between IAV and LVEDV changes at six months (r = 0.403, p = 0.04). Conclusions: The development of cardiac dyssynchrony correlates with adverse left ventricular remodeling after MI (Rev Med Chile 2009; 137: 1457-62).
- ItemDevelopment of a Swine Model of Left Bundle Branch Block for Experimental Studies of Cardiac Resynchronization Therapy(2013) Rigol, Montserrat; Solanes, Núria; Fernández-Armenta, Juan; Silva, Etelvino; Doltra, A.; Duchateau, Nicolas; Barcelo, Aina; Gabrielli, Luigi; Bijnens, Bart; Berruezo, Antonio; Brugada, Josep; Sitges, Marta
- ItemDifferential atrial performance at rest and exercise in athletes: Potential trigger for developing atrial dysfunction?(2016) Gabrielli, Luigi; Bijnens, B. H.; Brambila, C.; Duchateau, N.; Marin, J.; Sitges Serra, I.; Mont, L.; Brugada, J.; Sitges, M.
- ItemDyssynchronization reduces dynamic obstruction without affecting systolic function in patients with hypertrophic obstructive cardiomyopathy : a pilot study(2016) Giraldeau, G.; Duchateau, N.; Bijnens, B.; Gabrielli, Luigi; Penela, D.; Evertz, R.; Mont, L.; Brugada, J.; Berruezo, A.; Sitges, M.
- ItemEarly left atrial dysfunction is associated with suboptimal cardiovascular health(2020) Ocaranza Jeraldino, M. Paz; Bambs S., Claudia; Salinas Fuentealba, Manuel Alejandro; Matamala, C; García, L; Troncoso, R; Pedrozo, Z; Huidobro, A; Venegas, P; Paredes, F; Giacaman, A; Zalaquett Sepúlveda, Ricardo; Chiong, M; Verdejo Pinochet, Hugo; Ferreccio Readi, Catterina; Lavandero, S; Castro Gálvez, Pablo Federico; Gabrielli, Luigi; Ocaranza Jeraldino, M. Paz; Bambs S., Claudia; Salinas Fuentealba, Manuel Alejandro; Matamala, C; García, L; Troncoso, R; Pedrozo, Z; Huidobro, A; Venegas, P; Paredes, F; Giacaman, A; Zalaquett Sepúlveda, Ricardo; Chiong, M; Verdejo Pinochet, Hugo; Ferreccio Readi, Catterina; Lavandero, S; Castro Gálvez, Pablo Federico; Gabrielli, Luigi; Ocaranza, María Paz; Bambs S., Claudia; Salinas Fuentealba, Manuel Alejandro; Matamala, C; García, L; Troncoso, R; Pedrozo, Z; Huidobro, A; Venegas, P; Paredes, F; Giacaman, A; Zalaquett Sepúlveda, Ricardo; Chiong, M; Verdejo Pinochet, Hugo; Ferreccio Readi, Catterina; Lavandero, S; Castro Gálvez, Pablo Federico; Gabrielli, Luigi; Ocaranza, María Paz; Bambs S., Claudia; Salinas Fuentealba, Manuel Alejandro; Matamala, C; García, L; Troncoso, R; Pedrozo, Z; Huidobro, A; Venegas, P; Paredes, F; Giacaman, A; Zalaquett Sepúlveda, Ricardo; Chiong, M; Verdejo Pinochet, Hugo; Ferreccio Readi, Catterina; Lavandero, S; Castro Gálvez, Pablo Federico; Gabrielli, Luigi
- ItemEcocardiografía transesofágica tridimensional en la evaluación: guía y seguimiento de intervenciones cardíacas percutáneas(2012) Gabrielli, Luigi; Brambila, C.; Robles, R.; Montserrat, S.; Vidal, B.; Azqueta, M.; Stiges, M.; Paré, C.
- ItemEdad mayor a sesenta años y tabaquismo son predictores de la presencia ecocardiográfica de placa aórtica complicada en pacientes con accidente cerebrovascular isquémico sin cardiopatía(2012) Ramírez, P.; Córdova, S.; Lindefjeld, Dante; Gabrielli, Luigi; Mc-Nab Martin, Paul Andrew; Braun Jones, Sandra; Godoy, I.; Fernández, M. S.Introducción: El ACV es la segunda causa específica de muerte en nuestro país, siendo el origen cardioembólico responsable del 20% al 40% de los casos. En pacientes sin patología cardiovascular evidente, clínica o por ecocardiografía transtorácica (ETT), la identificación de la fuente embólica requiere la realización de ecocardiografía transesofágica (ETE), que puede confirmar la presencia de una placa aórtica complicada (PAC) como agente causal de este fenómeno. Objetivo: Evaluar cuales son los predictores clínicos para la presencia de PAC que permitan definir y estratificar aquellos pacientes que más se beneficien de la búsqueda cardioembólica mediante el ETE. Métodos: Se analizaron todos los pacientes con diagnóstico de ACV isquémico ingresados a nuestro hospital entre enero del 2008 a diciembre del 2010, co-!respondientes a 398 pacientes. Se excluyeron 112 por presentar historia de arritmias o tener ETT anormal. A los 286 pacientes restantes se les realizó un ETE, para analizar la presencia o no de PAC. Se compararon características clínicas y ecográficas entre aquellos con y sin PAC. Se utilizó chi-cuadrado, test exacto de Fisher, test U Mann Whitney y regresión logística binaria. Resultados: En los 286 pacientes el ETE detectó placas aórticas en 163 (57%) pacientes; de éstos, 32 (11.19 %) presentaban PAC. Por análisis multivariado se identificaron como predictores independientes de la presencia de PAC a la edad > 60 años (OR 6.232, p 0.001) y al tabaquismo (OR 4.893, p <0.001). Conclusiones: A la luz de estos resultados, se podría sugerir que en casos de AVE/TIA de pacientes en ritmo sinusal y sin cardiopatía evidente por ETT, se debería realizar ETE al menos en fumadores y en pacientes > de 60 años.
- ItemEffect of cardiac resynchronization therapy on left ventricular diastolic function : Implications for clinical outcome(2013) Doltra, Adelina; Bijnens, Bart; Tolosana, José María; Gabrielli, Luigi; Castel, María Ángeles; Berruezo, Antonio; Brugada, Josep; Mont, Lluís; Sitges, Marta
- ItemEffect of Early Normotension with Olmesartan on Rho-kinase Activity in Hypertensive Patients(2020) Cantin, C; Jalil Milad, Jorge; Bulnes, JF; Novoa, Ulises; MacNab, P; Godoy, I.; Córdova, S.; Gabrielli, Luigi; Ocaranza Jeraldino, M. Paz; Cantin, C; Jalil Milad, Jorge; Bulnes, JF; Novoa, Ulises; MacNab, P; Godoy, I.; Córdova, S.; Gabrielli, Luigi; Ocaranza, María Paz
- ItemEffectiveness of respiratory muscles training by voluntary isocapnic hyperpnea versus inspiratory threshold loading on intercostales and vastus lateralis muscles deoxygenation induced by exercise in physically active adults(2023) Espinosa Ramírez, Maximiliano; Riquelme Sánchez, Santiago; Araya, Felipe; Rodríguez, Guido; Figueroa Martínez, Fernanda; Gabrielli, Luigi; Viscor, Ginés; Reid, W. Darlene; Contreras-Briceño, Felipe; Pontificia Universidad Católica de Chile. Escuela de MedicinaTesis conducente al grado de Magíster en Investigación en Ciencias de la Salud. Abstract: Respiratory muscle training (RMT) improves physical performance, although it is still debated whether this effect depends on the type of training. The purpose of this study was to compare the effects of two different types of RMT, i.e., voluntary isocapnic hyperpnea (VIH) and inspiratory threshold loading (ITL), on the deoxygenation of intercostal (∆SmO2-m. intercostales) and vastus lateralis (∆SmO2-m. vastus lateralis) muscles during exercise. Twenty-four participants performed eight weeks of RMT by: (i) VIH (3 days·week−1 for 12 min at 60% maximal voluntary ventilation) or (ii) ITL (5 sets·week−1 of 30 breaths·minute−1 at 60% maximal inspiratory pressure). Cardiopulmonary exercise testing (CPET) included ∆SmO2 (the change from baseline to end of test) of intercostal and vastus lateralis muscles. After RMT, both groups showed decreased ∆SmO2-m. intercostales (VIH = 12.8 ± 14.6%, p = 0.04 (effect size, ES = 0.59), and ITL = 8.4 ± 9.8%, p = 0.04 (ES = 0.48)), without a coincident change of ∆SmO2-m. vastus lateralis. ITL training induced higher VO2-peak absolute values than VIH (mean ∆ post–pre, ITL = 229 ± 254 mL·min−1 [95% CI 67–391] vs. VIH, 39 ± 153 mL·min−1 [95% CI −58–136.0], p = 0.01). In conclusion, both RMT improved the balance between supply and oxygen consumption levels of m. intercostales during CPET, with ITL also inducing an increase of aerobic capacity.