Browsing by Author "Fernández, P."
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- ItemA phase 2, randomized double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season(2010) Fernández, P.; Trenholme, A.; Abarca Villaseca, Katia; Griffin, M. P.; Hultquist, M.; Harris, B.; Losonsky, G. A.
- ItemDevelopment of an instrument to measure the cultural competence of health care workers(2020) Pedrero, V.; Bernales, Margarita; Chepo, M.; Manzi Astudillo, Jorge; Pérez, M.; Fernández, P.
- ItemInhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease(2017) Yi, C.; Ezan, P.; Fernández, P.; Schmitt, J.; Sáez, Juan Carlos; Giaume, C.; Koulakoff, A.
- ItemMendelian Randomization Analysis of the Relationship Between Native American Ancestry and Gallbladder Cancer Risk(2022) Zollner, L.; Boekstegers, F.; Ponce, C.B.; Scherer, D.; Marcelain, K.; Gárate-Calderón, V.; Waldenberger, M.; Morales, E.; Rojas, A.; Munoz, C.; Müller, B.; Retamales, J.; de Toro, G.; Kortmann, A.V.; Barajas, O.; Rivera, M.T.; Cortés, A.; Loader, D.; Saavedra, J.; Gutiérrez, L.; Ortega, A.; Bertrán, M.E.; Bartolotti, L.; Gabler, F.; Campos, M.; Alvarado, J.; Moisán, F.; Spencer, L.; Nervi Nattero, Bruno; Carvajal, D.; Losada, H.; Almau, M.; Fernández, P.; Olloquequi, J.; Carter, A.R.; Miquel, Juan Francisco; Bustos, B.I.; Guajardo, M.F.; Gonzalez-Jose, R.; Bortolini, M.C.; Acuña-Alonzo, V.; Gallo, C.; Linares, A.R.; Rothhammer, F.; Bermejo, J.L.Background A strong association between the proportion of Native American ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest Native American people in Chile. We set out to investigate the causal association between Native American Mapuche ancestry and GBC risk, and the possible mediating effects of gallstone disease and body mass index (BMI) on this association. Methods Markers of Mapuche ancestry were selected based on the informativeness for assignment measure and then used as instrumental variables in two-sample mendelian randomization (MR) analyses and complementary sensitivity analyses. Result We found evidence of a causal effect of Mapuche ancestry on GBC risk (inverse variance-weighted (IVW) risk increase of 0.8% for every 1% increase in Mapuche ancestry proportion, 95% CI 0.4% to 1.2%, p = 6.6×10-5). Mapuche ancestry was also causally linked to gallstone disease (IVW risk increase of 3.6% per 1% increase in Mapuche proportion, 95% CI 3.1% to 4.0%, p = 1.0×10-59), suggesting a mediating effect of gallstones in the relationship between Mapuche ancestry and GBC. In contrast, the proportion of Mapuche ancestry showed a negative causal effect on BMI (IVW estimate -0.006 kg/m2 per 1% increase in Mapuche proportion, 95% CI -0.009 to -0.003, p = 4.4×10-5). Conclusions The results presented here may have significant implications for GBC prevention and are important for future admixture mapping studies. Given that the association between Mapuche ancestry and GBC risk previously noted in observational studies appears to be causal, primary and secondary prevention strategies that take into account the individual proportion of Mapuche ancestry could be particularly efficient.
- ItemNeural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells(2015) Talaverón, R.; Fernández, P.; Escamilla, R.; Pastor, A.; Matarredona, E.; Sáez, Juan Carlos
- ItemReducción de incidencia de neumonía asociada a ventilación mecánica post cirugía cardíaca: experiencia de 13 años de vigilancia epidemiológica en un hospital universitario(2013) Ajenjo Henríquez, María Cristina; Zambrano González, Alejandra Andrea; Eugenin, María I.; Achurra Tirado, Pablo; Zalaquett Sepúlveda, Ricardo; Irarrázaval Llona, Manuel José; De La Cerda Soto, María Gabriela; Fernández, P.; Barañao Garcés, Patricio; Fuentealba Westermans, Patricia; Ferrés Garrido, Marcela Viviana; García Cañete, Patricia; Pérez, Carlos; Labarca L., Jaime
- ItemStretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation(2020) López Lagos, Ximena Monserrat; Escamilla, R.; Fernández, P.; Duarte, Y.; González Nilo, F.; Palacios Prado, Nicolás; Martínez, A. D.; Sáez, Juan Carlos
- ItemThe FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway(2021) Recabal, A.; Fernández, P.; López, S.; Barahona, M. J.; Ordenes, P.; Palma, A.; Elizondo-Vega, R.; Farkas, C.; Uribe, A.; Sáez, Juan Carlos; Caprile, T.; García-Robles, M. A.