Browsing by Author " Schwarz Flores, Karla Gabriele"
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- ItemCardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats(2020) Lucero, C. M.; Andrade Andrade, David Cristóbal; Toledo, C.; Diaz, H. S.; Pereyra, K. V.; Díaz Jara, Esteban; Schwarz Flores, Karla Gabriele; Marcus, N. J.; Retamal, M. A.; Quintanilla Gómez, Rodrigo Arthur; Del Río, R.
- ItemCognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus(2019) Toledo, C.; Lucero, C.; Andrade Andrade, David Cristóbal; Diaz, H.S.; Schwarz Flores, Karla Gabriele; Pereyra, K.V.; Arce-Alvarez, A.; Lopez, N.A.; Martinez, M.; Inestrosa Cantín, Nibaldo; Del Rio, R.
- ItemCorrection to : Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure(2022) Schwarz Flores, Karla Gabriele; Pereyra Florián, Katherin Vanessa; Toledo, Camilo; Andrade Andrade, David Cristóbal; Díaz, Hugo S.; Díaz Jara, Esteban; Ortolani, Domiziana; Ríos Gallardo, Angélica; Arias, Paulina; Las Heras, AlexandraAn amendment to this paper has been published and can be accessed via the original article.
- ItemDietary supplementation of a sulforaphane-enriched broccoli extract protects the heart from acute cardiac stress(2020) Pereyra Florián, Katherin Vanessa; Andrade Andrade, David Cristóbal; Toledo, C.; Schwarz Flores, Karla Gabriele; Uribe-Ojeda, A.; Ríos-Gallardo, A. P.; Quintanilla, Rodrigo A.; Contreras E., Samuel; Mahn, A.; Río Troncoso, Rodrigo Andre del
- ItemEffects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure(2021) Schwarz Flores, Karla Gabriele; Pereyra Florián, Katherin Vanessa; Toledo, Camilo; Andrade Andrade, David Cristóbal; Díaz, Hugo S.; Díaz Jara, Esteban; Ortiz Cisternas, Fernando Andrés; Inestrosa Cantín, Nibaldo; Vio Lagos, Carlos P.; Río Troncoso, Rodrigo Andre delChronic heart failure (CHF) is a global health problem. Increased sympathetic outfow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K+) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K+ consumption may exert similar efects in CHF has not been previously tested. Accordingly, we aimed to evaluate the efects of dietary K+ supplementation on cardiorespiratory alterations in rats with CHF. Methods: Adult male Sprague–Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K+ diet (CHF+K+ group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outfow, barorefex sensitivity, breathing disorders, chemorefex function, respiratory–cardiovascular coupling and cardiac function were evaluated. Results: Compared to normal chow diet, K+ supplemented diet in CHF signifcantly reduced arrhythmia incidence (67.8±15.1 vs. 31.0±3.7 events/hour, CHF vs. CHF+K+), decreased cardiac sympathetic tone (ΔHR to propranolol: −97.4±9.4 vs. −60.8±8.3 bpm, CHF vs. CHF+K+), restored barorefex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K+ restores normal central respiratory chemorefex drive and abrogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function. Conclusion: Our fndings support that dietary K+ supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction.
- ItemEpisodic stimulation of central chemoreceptor neurons elicits disordered breathing and autonomic dysfunction in volume overload heart failure(2020) Diaz, HS; Andrade Andrade, David Cristóbal; Toledo, C; Pereyra, KV; Schwarz Flores, Karla Gabriele; Díaz Jara, Esteban; Lucero, C; Arce-Alvarez, A; Schultz, HD; Silva, JN; Takakura, AC; Moreira, TS; Marcus, NJ; Del Rio, R