Growth Dynamics in a Mechanical Model of Cellular Colonies
| dc.catalogador | gjm | |
| dc.contributor.advisor | Düring, Gustavo | |
| dc.contributor.author | Álvarez Murphy, Fidel Gerardo | |
| dc.contributor.other | Pontificia Universidad Católica de Chile. Instituto de Física | |
| dc.date.accessioned | 2024-07-22T20:00:05Z | |
| dc.date.available | 2024-07-22T20:00:05Z | |
| dc.date.issued | 2024 | |
| dc.date.updated | 2024-07-19T14:55:44Z | |
| dc.description | Tesis (Master’s degree in Physics)--Pontificia Universidad Católica de Chile, 2024. | |
| dc.description.abstract | Cellular colonies are structures of microorganisms that remain attached toeach other and/or to a surface. To study the effects of mechanical stress on thedynamics of a growing colony, a minimal discrete physical model of these cellu-lar systems is proposed considering only microscopic quantities from mechanicalforces, and a cell growth and division process. Using simulations that model thediscrete model evolution, macroscopic dynamics of contact and growth withinnon-motile circular-shaped cell colonies are successfully reproducible. To find alink between the microscopic quantities involved in the dynamics and the macro-scopic observables, an out-of-equilibrium continuum theory is developed.Theobserved dynamics in the discrete model are accurately described by the contin-uum theory at the mesoscopic limit, describing along the colony the existenceof maximum inner pressure and velocity as a function of microscopic quantities.Particularly, a constitutive relation between velocity and inter-particle overlapis found, describing that the growth dynamics of a colony are equivalent in twospatial configurations: a free and a channel-limited expansion. As a second partof this work, given the dynamics of the system, a competitive genetic surfingdynamic is studied considering two different cell strains in the channel-limitedconfiguration. The observed genetic surf shows a frequency distribution of domi-nance between strains that transits from an exponential law with exponent ´3{2to a log-normal distribution depending on the initial strain relative proportionand the channel width, suggesting that this system’s competitive dynamics canbe described by mean-field theories that describe growth processes. | |
| dc.fechaingreso.objetodigital | 2024-07-22 | |
| dc.format.extent | 64 páginas | |
| dc.fuente.origen | Autoarchivo | |
| dc.identifier.doi | 10.7764/tesisUC/FIS/87203 | |
| dc.identifier.uri | https://doi.org/10.7764/tesisUC/FIS/87203 | |
| dc.identifier.uri | https://repositorio.uc.cl/handle/11534/87203 | |
| dc.information.autoruc | Instituto de Física; Düring, Gustavo; S/I; 1012766 | |
| dc.information.autoruc | Instituto de Física; Álvarez Murphy, Fidel Gerardo; S/I; 1064542 | |
| dc.language.iso | en | |
| dc.nota.acceso | contenido completo | |
| dc.rights | acceso abierto | |
| dc.rights.license | Atribución-CompartirIgual 4.0 Internacional (CC BY-SA 4.0) | |
| dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/deed.es | |
| dc.subject.ddc | 510 | |
| dc.subject.dewey | Matemática física y química | es_ES |
| dc.title | Growth Dynamics in a Mechanical Model of Cellular Colonies | |
| dc.type | tesis de maestría | |
| sipa.codpersvinculados | 1012766 | |
| sipa.codpersvinculados | 1064542 |